Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function

Authors: Livia Lopez-Noriega, Rebecca Callingham, Aida Martinez-Sánchez, Sameena Nawaz, Grazia Pizza, Nejc Haberman, Nevena Cvetesic, Marie-Sophie Nguyen-Tu, Boris Lenhard, Piero Marchetti, Lorenzo Piemonti, Eelco de Koning, A.M. James Shapiro, Paul R. Johnson, Isabelle Leclerc, Benoit Hastoy, Benoit R. Gauthier, Timothy J. Pullen, Guy A. Rutter

Source: iScience, Vol 28, Iss 1, Pp 111518- (2025)

Subject Terms: Cell biology, Cellular physiology, Molecular biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224027457; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/f195e6b6021d48928eb2e93138f9e0d3

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Authors: Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8eb84b4a486246dfb262ac9be25f0911

Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice

Authors: George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: SLC30A8, diabetes, pancreas, zinc, manganese, LA-ICP-MS, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1171933/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/75ed93d9f1f64c898d27e6bd1f975e33

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Authors: Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

Authors: Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: bariatric surgery, diabetes, adrenal glands, glucocorticoids, 11β-HSD1, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.1020576/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/715c140078e94857a79ede4b72cc3d99

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Authors: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alpy, Alice P.S. Kong, Peter I. Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter

Source: Molecular Metabolism, Vol 40, Iss , Pp 101015- (2020)

Subject Terms: Type 2 diabetes, Pancreatic β-cell, Lipid transporter, Insulin granule biogenesis, Phosphoinositides, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877820300892; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/075506f07a044c31be2e44b42ccc2527

Author Correction: Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Authors: Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter

Source: Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c286f4e96f8148e0ae12a0a2035467e5

Remote control of glucose homeostasis in vivo using photopharmacology

Authors: Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3ef948b53454487d84dd10b347df1987

RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis

Authors: Gao Sun, Richard Reynolds, Isabelle Leclerc, Guy A. Rutter

Source: Disease Models & Mechanisms, Vol 4, Iss 2, Pp 193-202 (2011)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/4/2/193; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/c21d494c54614c389c2f4de917cf10f6

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic β-cells

Authors: Gabriela da Silva Xavier, Guy A. Rutter, Frédérique Diraison, Chrysovalantis Andreolas, Isabelle Leclerc

Source: Journal of Lipid Research, Vol 47, Iss 11, Pp 2482-2491 (2006)

Subject Terms: glucolipotoxicity, lipogenic genes, chromatin immunoprecipitation, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S002222752043384X; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/4d29dd48fdd54b4b84eb5ea0adc87db4

Alcohol-associated bowel disease: new insights into pathogenesis

Authors: Bin Gao, Yves Horsmans, Peter Stärkel, Yaojie Fu, Luca Maccioni, Isabelle Leclercq, George Kunos

Source: eGastroenterology, Vol 1, Iss 1 (2023)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://egastroenterology.bmj.com/content/1/1/e100013.full; https://doaj.org/toc/2766-0125; https://doaj.org/toc/2976-7296

Access URL: https://doaj.org/article/fef09200eac94aceae05c9735d2b976a

Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis

Authors: Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclercq

Source: Hepatology Communications, Vol 3, Iss 7, Pp 867-882 (2019)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/7914a1d39a834bb090968621b92ee9d1

Rationale of adding muscle volume to muscle fat infiltration in the definition of an adverse muscle composition is unclear

Authors: Maxime Nachit, Yves Horsmans, Isabelle Leclercq

Source: JHEP Reports, Vol 3, Iss 2, Pp 100235- (2021)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555921000112; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/3dd8cfae17ca483f8282eefa35305f92

Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans

Authors: Luca Maccioni, Bei Gao, Sophie Leclercq, Boris Pirlot, Yves Horsmans, Philippe De Timary, Isabelle Leclercq, Derrick Fouts, Bernd Schnabl, Peter Stärkel

Source: Gut Microbes, Vol 12, Iss 1 (2020)

Subject Terms: alcohol, liver disease, dysbiosis, microbiota, gut barrier, microbial translocation, ck-18, alcohol use disorder, alcohol abstinence, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/01d9971efef049e09e3b4bda4670b7ce

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

Authors: Joost Willebrords, Bruno Cogliati, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Sara Crespo Yanguas, Michaël Maes, Veronica Mollica Govoni, Andressa Lima, Daniele Aparecida Felisbino, Elke Decrock, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Luc Leybaert, Robim Marcelino Rodrigues, Mathieu Vinken

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0ecf5b9e1964429e9ec61034a86fb689

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

Authors: Beate Czepukojc, Ali Abuhaliema, Ahmad Barghash, Sascha Tierling, Norbert Naß, Yvette Simon, Christina Körbel, Cristina Cadenas, Noemi van Hul, Agapios Sachinidis, Jan G. Hengstler, Volkhard Helms, Matthias W. Laschke, Jörn Walter, Johannes Haybaeck, Isabelle Leclercq, Alexandra K. Kiemer, Sonja M. Kessler

Source: Frontiers in Medicine, Vol 6 (2019)

Subject Terms: liver cancer, stem cell, de-differentiation, oval cell, HCC, fibrosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmed.2019.00179/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/40e7b69594ff4b559d37065944bdea6c

Digital Image Analysis of Picrosirius Red Staining: A Robust Method for Multi-Organ Fibrosis Quantification and Characterization

Authors: Guillaume E. Courtoy, Isabelle Leclercq, Antoine Froidure, Guglielmo Schiano, Johann Morelle, Olivier Devuyst, François Huaux, Caroline Bouzin

Source: Biomolecules, Vol 10, Iss 11, p 1585 (2020)

Subject Terms: fibrosis, picrosirius red, digital analysis, collagen proportionate area, whole section, region-of-interest, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/11/1585; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/f39cab9ca6ef437fbf3d22ce754fb4e2

Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism

Authors: Charlotte Lefort, Martin Roumain, Matthias Van Hul, Marialetizia Rastelli, Rita Manco, Isabelle Leclercq, Nathalie M. Delzenne, Vincenzo Di Marzo, Nicolas Flamand, Serge Luquet, Cristoforo Silvestri, Giulio G. Muccioli, Patrice D. Cani

Source: Cells, Vol 9, Iss 5, p 1247 (2020)

Subject Terms: NAPE-PLD, NAEs, bioactive lipids, bile acids, inflammation, liver, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/5/1247; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/d0c01fc3a2f5418db9bee67d01d18240

Equipe du soir, espoir : flexibilité chez Renault
Evening team, hope: flexibility at Renault

Contributors: Isabelle Leclercq, Jean François Haine, Michel de Virville, Philippe Martinez, Emmanuel Couvreur, Laurent Bignolas

Availability: http://data.europeana.eu/aggregation/europeana/04802/55833D18B721849A16E5115D84064EB85B497281