TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Authors: Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings

Source: Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 175-183 (2019)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050118301323; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/d1669924b97e44a4beafad9d2ebc6f23

Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis

Authors: Nathan J. Palpant, Yuliang Wang, Brandon Hadland, Rebecca J. Zaunbrecher, Meredith Redd, Daniel Jones, Lil Pabon, Rajan Jain, Jonathan Epstein, Walter L. Ruzzo, Ying Zheng, Irwin Bernstein, Adam Margolin, Charles E. Murry

Source: Cell Reports, Vol 20, Iss 7, Pp 1597-1608 (2017)

Subject Terms: human pluripotent stem cell, cardiovascular, hematopoiesis, chromatin dynamics, differentiation, genome engineering, Wnt signaling, epigenetics, cardiac, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717310604; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e989b68c8d95474a80bdd72eab2acc56

Blasts From Patients With Acute Myelogenous Leukemia Express Functional Receptors for Stem Cell Factor

Authors: Broudy, Virginia C., Smith, Franklin O., Nancy, Lin, Krisztina, Zsebo M., Joan, Egrie, Irwin, Bernstein D.

Source: Blood; July 1992, Vol. 80 Issue: 1 p60-67, 8p