Deep Learning Approaches for Morphological Classification of Intestinal Organoids

Authors: Cicceri, G., Di Bella, S., Di Franco, S., Stassi, G., Todaro, M., Vitabile, S.

Source: IEEE Access Access, IEEE. 13:62267-62287 2025

Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells

Authors: Meg Nakazawa, Itsuma Nagao, Yoko M. Ambrosini

Source: BMC Molecular and Cell Biology, Vol 26, Iss 1, Pp 1-11 (2025)

Subject Terms: Canine, Intestinal epithelial cells, Intestinal organoids, MHC class II, IFN-γ, Translational medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2661-8850

Access URL: https://doaj.org/article/482cd93e8416491293b5aba457502bf4

Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption

Authors: Kai Tanaka, Tatsuki Mochizuki, Shogo Baba, Shigeto Kawai, Kiyotaka Nakano, Tatsuhiko Tachibana, Kohsuke Uchimura, Atsuhiko Kato, Takashi Miyayama, Tomohito Yamaguchi, Hiroshi Nishihara, Kimio Terao, Yasutaka Kato

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-21 (2025)

Subject Terms: Drug absorption modeling, Human intestinal organoids, Pharmacokinetic prediction, In vitro drug screening, Precision drug development, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a939f41a83d1401c93b9d4623040ba80

Deliod a lightweight detection model for intestinal organoids based on deep learning

Authors: Yu Sun, Hanwen Zhang, Fengliang Huang, Qin Gao, Peng Li, Dong Li, Gangyin Luo

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-17 (2025)

Subject Terms: Intestinal organoids, Deep learning, YOLOv8s, Morphological analysis, Lightweight, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/37a284a0ea8f460d98874d343e2e9739

Extracellular Vesicles in Gut‐Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis

Authors: Han Liu, Ruiyang Li, Huijian Yang, Bo Situ, Guangchao Wang, Ke Xu, Jiacan Su

Source: Small Science, Vol 5, Iss 4, Pp n/a-n/a (2025)

Subject Terms: bacterial extracellular vesicles, gut microbiota, intestinal organoids, organoids extracellular vesicles, osteoporosis, Materials of engineering and construction. Mechanics of materials, TA401-492

File Description: electronic resource

Relation: https://doaj.org/toc/2688-4046

Access URL: https://doaj.org/article/41412fe387114addbe436bd4a63dc924

Intestinal organoids: The path towards clinical application

Authors: Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

Source: European Journal of Cell Biology, Vol 104, Iss 1, Pp 151474- (2025)

Subject Terms: Intestinal organoids, Clinical application, Personalized medicine, Drug screening, Regenerative medicine, Tissue engineering, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0171933524000918; https://doaj.org/toc/0171-9335

Access URL: https://doaj.org/article/5c561965e069451fb285dc4a21b46595

Challenges in validation of combination treatment strategies for CRC using patient-derived organoids

Authors: Valentin Benboubker, George M. Ramzy, Sacha Jacobs, Patrycja Nowak-Sliwinska

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)

Subject Terms: Combinatory treatment, Immunotherapy, Intestinal organoids, Intestinal tumor organoids, Precision medicine, Synergy evaluation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/010b61716bf24686873cba423601682b

Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids

Authors: Ilaria Bellini, Daniela Scribano, Cecilia Ambrosi, Claudia Chiovoloni, Silvia Rondón, Annamaria Pronio, Anna Teresa Palamara, Agostina Pietrantoni, Anna Kashkanova, Vahid Sandoghdar, Stefano D’Amelio, Serena Cavallero

Source: Parasites & Vectors, Vol 17, Iss 1, Pp 1-15 (2024)

Subject Terms: Anisakiasis, Extracellular vesicles, Tumorigenic potential, Immunomodulation, Human intestinal organoids, Inflammation, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/231dfd5627944a2bbf11e1cb97862b7e

CSF1 is expressed by the intestinal epithelial cells to regulate Mφ macrophages and maintain epithelial homeostasis and is downregulated in neonates with necrotizing enterocolitis

Authors: Xu Sun, Lingqi Xu, Shurong Ma, Jun Du, Huajian Gu, Jian Wang

Source: BMC Pediatrics, Vol 24, Iss 1, Pp 1-10 (2024)

Subject Terms: Neonates, Necrotizing enterocolitis, Inflammation, Macrophages, CSF1, Intestinal organoids, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2431

Access URL: https://doaj.org/article/7f23a5c7346b4a3b8ab056fe0aa6ec18

Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids

Authors: Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

Source: European Journal of Cell Biology, Vol 104, Iss 2, Pp 151479- (2025)

Subject Terms: Intestinal organoids, Small intestine, IPS cell, Drug-metabolizing enzymes, Drug transporters, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0171933525000044; https://doaj.org/toc/0171-9335

Access URL: https://doaj.org/article/5b7d5fdeb9ee43f7b44192e4f7444500

A novel scheme for non-invasive drug delivery with a magnetically controlled drug delivering capsule endoscope

Authors: Wang, Weijun ^{a, 1}, Zhang, Kun ^{a, 1}, Ming, Fanhua ^b, Chen, Biao ^c, Zhang, Hao ^b, Wang, Zhe ^a, Jiang, Xin ^a, Zhang, Hang ^b, Shang, Guochen ^a, Bao, Yuhui ^b, Peng, Hangyu ^b, Liu, Shanshan ^a, Ling, Xin ^a, Li, Wenhao ^a, Zhu, Huanpeng ^a, Zhang, Yurui ^a, Cai, Sicheng ^a, Ding, Zhen ^{d, ⁎}, Lin, Rong ^{a, ⁎⁎}

Source: In Journal of Controlled Release 10 May 2025 381

Label-free cell imaging and tracking in 3D organoids

Authors: Kok, Rutger N.U. ¹, Spoelstra, Willem Kasper ¹, Betjes, Max A. ¹, van Zon, Jeroen S. ^{1, ∗}, Tans, Sander J. ^{1, 2, 3, ∗∗}

Source: In Cell Reports Physical Science 16 April 2025 6(4)

Interferon-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins

Authors: Wang, Daisong ^{1, 2}, Spoelstra, Willem Kasper ³, Lin, Lin ^{1, 2, 4}, Akkerman, Ninouk ^{1, 2, 6}, Krueger, Daniel ^{1, 2}, Dayton, Talya ^{1, 2, 7}, van Zon, Jeroen S. ³, Tans, Sander J. ^{3, 5}, van Es, Johan H. ^{1, 2}, Clevers, Hans ^{1, 2, 4, 6, 8, ∗}

Source: In Cell Stem Cell 3 April 2025 32(4):598-612

Preparation and functional identification of various porcine cytokines

Authors: Yang, Shanshan ^{a, b, c, 1}, Cao, Qiuxia ^{a, d, 1}, Yan, Kexin ^a, Wang, Chuanhong ^a, Song, Xu ^a, Bian, Xianyu ^a, Li, Sufen ^a, Cheng, Zhenkong ^a, Zhang, Xuehan ^a, Wang, Yi ^a, Guo, Rongli ^{a, b, c}, Wang, Xiaodu ^d, Song, Houhui ^d, Fan, Baochao ^{a, b, c, ⁎}, Li, Bin ^{a, b, c, ⁎}

Source: In Cytokine April 2025 188

Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report

Authors: Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

Source: Respiratory Medicine Case Reports, Vol 53, Iss , Pp 102171- (2025)

Subject Terms: Non-small cell lung cancer, Elexacaftor/tezacaftor/ivacaftor, Cystic fibrosis, ALK translocation, Intestinal organoids, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213007125000073; https://doaj.org/toc/2213-0071

Access URL: https://doaj.org/article/9a95f9bda5c549f8bee867d10f8231cf

Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem CellsSummary

Authors: Kentaro Tominaga, Daniel O. Kechele, J. Guillermo Sanchez, Simon Vales, Ingrid Jurickova, Lizza Roman, Akihiro Asai, Jacob R. Enriquez, Heather A. McCauley, Keishi Kishimoto, Kentaro Iwasawa, Akaljot Singh, Yuko Horio, Jorge O. Múnera, Takanori Takebe, Aaron M. Zorn, Michael A. Helmrath, Lee A. Denson, James M. Wells

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 19, Iss 4, Pp 101444- (2025)

Subject Terms: Human Intestinal Organoids, Tissue-Resident Macrophages, Immune Cells, Inflammatory Bowel Disease, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X24001991; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/d102c6f7447d4691a96f3fab730e28da

Titanium dioxide nanoparticles disturb glucose homeostasis in association with impaired enteroendocrine cell differentiation

Authors: Zou, Kai ^{a, b}, Du, Linna ^a, Qin, Jing ^a, Zhou, Jiacheng ^a, Xiao, Yanping ^a, Song, Xixi ^a, Liu, Hongxia ^a, Wang, Xiu ^{a, b, ⁎}

Source: In Food and Chemical Toxicology August 2025 202

In vitro and in vivo evaluation of thapsigargin as an antiviral agent against transmissible gastroenteritis virus

Authors: Yang Li, Yuanyuan Liu, Yunhang Zhang, Chen Tan, Yifei Cai, Yue Zhang, Jianing Chen, Yuguang Fu, Guangliang Liu

Source: Veterinary Research, Vol 55, Iss 1, Pp 1-13 (2024)

Subject Terms: thapsigargin, intestinal organoids, ERS, antiviral drug, TGEV, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/1f74fcd985914125b1b8a7dee17b7bc9

Virulence expression difference to intestinal cells of different pathogenic Listeria monocytogenes contaminating sausages after simulated digestive tract

Authors: Zhou, Cong ^{a, b, 1}, Zou, Yafang ^{b, 1}, Huang, Haorui ^b, Zhao, Fanwen ^b, Fan, Xia ^b, Bai, Li ^a, Zhang, Xinhao ^a, Ye, Keping ^{b, ⁎}

Source: In International Journal of Food Microbiology 16 February 2025 430

Disruption of serotonin homeostasis in intestinal organoids provides insights into drug-induced gastrointestinal toxicity

Authors: Rouseti, Georgia M. ^{a, b}, Fischer, Audrey ^{a, 1}, Rathfelder, Nicole ^{a, c, 1}, Grimes, Karen ^a, Waldt, Annick ^a, Cuttat, Rachel ^a, Schuierer, Sven ^a, Wild, Sophia ^a, Jivkov, Magali ^a, Dubost, Valerie ^a, Schadt, Heiko S. ^a, Odermatt, Alex ^{b, d}, Vicart, Axel ^{a, ⁎}, Moretti, Francesca ^{a, ⁎}

Source: In Toxicology February 2025 511