Fluorofenidone attenuates choline-deficient, l-amino acid-defined, high-fat diet-induced metabolic dysfunction-associated steatohepatitis in mice

Authors: Jian Zhang, Qianbing Wang, Nianqi Zhou, Jinqing Liu, Lijian Tao, Zhangzhe Peng, Gaoyun Hu, Huiwen Wang, Lei Fu, Shifang Peng

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Metabolic dysfunction-associated steatotic liver disease, Metabolic dysfunction-associated steatohepatitis, Fluorofenidone, AMPK, NLRP3 inflammasome, TGFβ1/SMAD pathway, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f4b370346bc04416a409aefb7bb02ff4

NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis

Authors: Maggie Lam, Kristian T. Barry, Christopher J. Hodges, Christopher M. Harpur, James D. H. Ong, Sarah Rosli, Alison C. West, Lovisa Dousha, Paul J. Hertzog, Ashley Mansell, Michelle D. Tate

Source: Respiratory Research, Vol 26, Iss 1, Pp 1-17 (2025)

Subject Terms: Silicosis, NLRP3 inflammasome, Mouse model, Inflammation, Fibrosis, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/43e7af70a23e4fc4969c7335cba14e91

Artificial intelligence-powered prediction of AIM-2 inflammasome sequences using transformers and graph attention networks in periodontal inflammation

Authors: Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: Aim-2, Graph attention networks, RNN-CNN, Transformers, Periodontitis, Inflammasome, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b505e741ae1f4dc4ba4b6ea6fa00a6f5

Clinical significance and pathogenesis of GBP5 in infectious mononucleosis associated liver injury

Authors: Yan Li, Jiamei Tang, Yulan Ma, Yujuan Yan, Fangfang Cheng, Kun Wang

Source: Italian Journal of Pediatrics, Vol 51, Iss 1, Pp 1-9 (2025)

Subject Terms: GBP5, infectious mononucleosis, Liver injury, NLRP3 inflammasome, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://doaj.org/toc/1824-7288

Access URL: https://doaj.org/article/38a97eb136424659865853586b645ca8

Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation

Authors: Hye-Young Seo, Ji Yeon Park, So-Hee Lee, Hye Won Lee, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang

Source: Cell & Bioscience, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Clusterin, Cholestatic liver, ER stress, NLRP3 inflammasome, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/5a724d39a0ec407fbc5f3c4c0a0a8026

Hotspots and Trends in Allergic Rhinitis Nasal Mucosa Studies: A Bibliometric Analysis (2010-2024)

Authors: Wang M, Fu L, Wang H, Tian L

Source: Journal of Asthma and Allergy, Vol Volume 18, Pp 417-435 (2025)

Subject Terms: autophagy, nlrp3 inflammasome, mirnas, citespace, visualization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.dovepress.com/hotspots-and-trends-in-allergic-rhinitis-nasal-mucosa-studies-a-biblio-peer-reviewed-fulltext-article-JAA; https://doaj.org/toc/1178-6965

Access URL: https://doaj.org/article/c44a8cde3720438faf3d4b9b82f45fcd

Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice

Authors: Ju Hwan Jeong, Sun‐Ok Kim, Seong Cheol Min, Eung‐Gook Kim, Min‐Suk Song, Eun‐Young Shin

Source: FEBS Open Bio, Vol 15, Iss 3, Pp 427-435 (2025)

Subject Terms: infection, inflammasome, K18‐hACE2, regorafenib, SARS‐CoV‐2, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/1609bc15761e457693f80f9d066a1819

Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Authors: Rong-Xin Zhu, Rui-Xue Han, Yue-Han Chen, Lei Huang, Ting Liu, Jingwei Jiang, Cong Wang, Lei Cao, Yang Liu, Ming Lu

Source: Molecular Neurodegeneration, Vol 20, Iss 1, Pp 1-21 (2025)

Subject Terms: NLRP3 inflammasome, Phosphorylation, Serine 658, Inflammation, Parkinson’s disease, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/552cd2762340478b98459ec3cc3a2e1d

Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats

Authors: Kui W, Li Y, Gu Z, Xie L, Huang A, Kong S, Song L, Li L, Yu J, Xue CC, Wang K

Source: Journal of Pain Research, Vol Volume 18, Pp 1115-1129 (2025)

Subject Terms: nlrp3 inflammasome, electroacupuncture, neuropathic pain, pyrotosis, neuroinflammation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/electroacupuncture-inhibits-nlrp3-mediated-microglial-pyroptosis-to-am-peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/a2cfcbbce8284dcda4b65c757514fbee

Saccharomyces boulardii Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis

Authors: Yang L, Li W, Zhao Q, Mo Q, Liu T, Cao H

Source: Journal of Inflammation Research, Vol Volume 18, Pp 3161-3176 (2025)

Subject Terms: saccharomyces boulardii, farnesoid x receptor, nlrp3 inflammasome, macrophages, pyroptosis, colitis., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/saccharomyces-boulardii-alleviates-colitis-by-regulating-fxr-nlrp3-med-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/d738818c756640a9b793d146f68fb99d

Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation

Authors: Léana Gorse, Loïc Plessis, Stephen Wearne, Margaux Paradis, Miriam Pinilla, Rae Chua, Seong Soo Lim, Elena Pelluz, Gee-Ann TOH, Raoul Mazars, Caio Bomfim, Fabienne Hervé, Korian Lhaute, Damien Réveillon, Bastien Suire, Léa Ravon-Katossky, Thomas Benoist, Léa Fromont, David Péricat, Kenneth Neil Mertens, Amélie Derrien, Aouregan Terre-Terrillon, Nicolas Chomérat, Gwenaël Bilien, Véronique Séchet, Liliane Carpentier, Mamadou Fall, Amidou Sonko, Hadi Hakim, Nfally Sadio, Jessie Bourdeaux, Céline Cougoule, Anthony K Henras, Ana Belen Perez-Oliva, Patrice Brehmer, Francisco J Roca, Franklin L Zhong, John Common, Etienne Meunier, Philipp Hess

Source: EMBO Molecular Medicine, Vol 17, Iss 3, Pp 535-562 (2025)

Subject Terms: Skin Pathology, Environmental Toxins, Ribotoxic Stress Response, NLRP1 Inflammasome, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/d931c859ed67483faf1d0d8c2cc4ec48

Inflammation in cancer: therapeutic opportunities from new insights

Authors: Yifei Xie, Fangfang Liu, Yunfei Wu, Yuer Zhu, Yanan Jiang, Qiong Wu, Zigang Dong, Kangdong Liu

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-96 (2025)

Subject Terms: Inflammation, Cytokine, Inflammasome, Cancer prevention and treatment, FDA-approved drugs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/efb606b47932469b9e529a475e1b0c3e

FlaA N/C attenuates radiation-induced lung injury by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis

Authors: Shihua Deng, Yueyan Yang, Shuang He, Zixin Chen, Xun Xia, Ting Zhang, Qing Yin, Teng Liu, Dongming Wu, Kejian Pan, Ying Xu

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-20 (2025)

Subject Terms: Radiation-induced lung injury, Flagellin A N/C, Inflammasome autophagy, Beclin 1, Pyroptosis, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1ecfc90d1da64f35956fdf81132b91f6

Clusterin inhibits lipopolysaccharide induced liver injury

Authors: Hye-Young Seo, Ji Yeon Park, So-Hee Lee, Seong Hwan Cho, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Subject Terms: Clusterin, LPS, Liver inflammation, NLRP3 inflammasome, STAT3, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2ed37c7c90a94701806cce8909ff4772

The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β

Authors: Judith Bockstiegel, Jonas Engelhardt, Mirjam Schuchardt, Markus Tölle, Günther Weindl

Source: Molecular Medicine, Vol 31, Iss 1, Pp 1-18 (2025)

Subject Terms: IL-1beta, Adenosine 5′-tetraphosphate, ATP, NLRP3 inflammasome, Human macrophages, Metallothioneins, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/9b235ca6ecef4d718bd787aca97d2a54

Inhibition of mir-155-5p alleviates cardiomyocyte pyroptosis induced by hypoxia/reoxygenation via targeting SIRT1-mediated activation of the NLRP3 inflammasome

Authors: Qiuyu Lu, Qingrong Shen, Jinmei Su, Xin Li, Bingyu Xia, Aicun Tang

Source: Journal of Cardiothoracic Surgery, Vol 20, Iss 1, Pp 1-11 (2025)

Subject Terms: Myocardial infarction, Hypoxia/reoxygenation, Cardiomyocyte, Pyroptosis, NLRP3 inflammasome, Surgery, RD1-811, Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: https://doaj.org/toc/1749-8090

Access URL: https://doaj.org/article/b272b03de22c4a24b4d8cfe6d8b2d6ae

Bidirectional Regulation of Keratinocyte Proliferation and Apoptosis by Metformin via NLRP3 Inflammasome Pathway

Authors: TIAN Ke, LENG Qiufeng, LYU Jing, MIAO Guoying, WANG Xinhui, XIE Hui, LIU Qu, YAO Chunxia

Source: Zhongguo quanke yixue, Vol 28, Iss 06, Pp 742-750 (2025)

Subject Terms: metformin, nlrp3 inflammasome, hacat cells, cell proliferation, cell apoptosis, lichen planus, psoriasis, mice, Medicine

File Description: electronic resource

Relation: https://www.chinagp.net/fileup/1007-9572/PDF/2024-010058.pdf; https://doaj.org/toc/1007-9572

Access URL: https://doaj.org/article/92b7775d9bfb48a5b52d917dbc72a9e8

Research progress on NLRP3 inflammasome-mediated regulation of tissue remodeling during orthodontic tooth movement

Authors: WANG Jiajia, ZHANG Jiangtao, ZENG Fulei

Source: 口腔疾病防治, Vol 33, Iss 2, Pp 169-176 (2025)

Subject Terms: nlrp3 inflammasome, orthodontic tooth movement, interleukin-1β, interleukin-18, pyroptosis, alveolar bone, periodontitis, root resorption, Medicine

File Description: electronic resource

Relation: https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2025）02-169-08.pdf; https://doaj.org/toc/2096-1456

Access URL: https://doaj.org/article/66ba7ab42e3c4336af99e07931b7830b

BRISC inactivation alleviates alcohol-induced liver injury in mice

Authors: Ting Wang, Wen Zhang, Xian Liu, Kai Liu, Guang-Ming Ren, Shen-Si Xiang, Yi-Qun Zhan, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Yan Li, Xiao-Ming Yang, Rong-Hua Yin

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: Alcoholic liver disease, BRISC, Thiolutin, Liver steatosis, Inflammation, NLRP3 inflammasome, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1e1f304f873a4fd18481cbe0ff67e978

Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression

Authors: Jinfu Zhuang, Zhicheng Zhuang, Bin Chen, Yuanfeng Yang, Hengkai Chen, Guoxian Guan

Source: Molecular Medicine, Vol 31, Iss 1, Pp 1-14 (2025)

Subject Terms: Inflammatory bowel disease, Odoribacter splanchnicus, Extracellular vesicles, Intestinal tight junction, NLRP3 inflammasome, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/bbb1ac438e8344dc88aff6c04a5e0aaa