Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box

Authors: Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Ines Sifaoui, José E. Piñero, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100545- (2024)

Subject Terms: Naegleria fowleri, Primary amoebic meningoencephalitis, Chemotherapy, COVID box, Programmed cell death, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320724000265; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/b2fd0062b30b41bb90dac94ed3a795e9

A giant virus infecting the amoeboflagellate Naegleria

Authors: Patrick Arthofer, Florian Panhölzl, Vincent Delafont, Alban Hay, Siegfried Reipert, Norbert Cyran, Stefanie Wienkoop, Anouk Willemsen, Ines Sifaoui, Iñigo Arberas-Jiménez, Frederik Schulz, Jacob Lorenzo-Morales, Matthias Horn

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7721d9818f0b49038d1df61f93658c70

Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri

Authors: Iñigo Arberas-Jiménez, Francisco Cen-Pacheco, Javier Chao-Pellicer, Ines Sifaoui, Aitor Rizo-Liendo, Ezequiel Q. Morales, Antonio H. Daranas, Ana R. Díaz-Marrero, José E. Piñero, José J. Fernández, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 61-71 (2023)

Subject Terms: Oxasqualenoids, Laurencia, Naegleria fowleri, Yucatecone, Primary amoebic meningoencephalitis, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320723000192; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/9d536d691f3d426ab5986c9f54c8e323

Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model

Authors: Rubén L. Rodríguez-Expósito, Ines Sifaoui, Lizbeth Salazar-Villatoro, Carlos J. Bethencourt-Estrella, José J. Fernández, Ana R. Díaz-Marrero, Robert Sutak, Maritza Omaña-Molina, José E. Piñero, Jacob Lorenzo-Morales

Source: Marine Drugs, Vol 22, Iss 9, p 423 (2024)

Subject Terms: Acanthamoeba, ex vivo, mouse cornea, staurosporine, proteomic analysis, PCD, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/22/9/423; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/d6b2822562ad486fbc0b763d11260afc

Influence of salt and temperature in the growth of pathogenic free-living amoebae

Authors: Iñigo Arberas-Jiménez, Rubén L. Rodríguez-Expósito, Ines Sifaoui, Javier Chao-Pellicer, Luis Sancho, Andoni Urruticoechea, José E. Piñero, Jacob Lorenzo-Morales

Source: Frontiers in Microbiology, Vol 15 (2024)

Subject Terms: Naegleria fowleri, Acanthamoeba, FLA, NaCl-tolerance, temperature, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1356452/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/384cb9abe3704480b0a75eeafebed5f4

First Report of Acanthamoeba Genotype T4 from the Newly Formed Tajogaite Volcano Tephra (La Palma, Canary Islands)

Authors: Patricia Pérez-Pérez, María Reyes-Batlle, Rubén L. Rodríguez-Expósito, Adolfo Perdomo-González, Ines Sifaoui, Francisco J. Díaz-Peña, Rodrigo Morchón, Sutherland K. Maciver, José E. Piñero, Jacob Lorenzo-Morales

Source: Pathogens, Vol 13, Iss 8, p 626 (2024)

Subject Terms: Acanthamoeba, tajogaite, La Palma, tephra, pathogenic potential, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/13/8/626; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/91194e2a41df42bdbc03e72a578c2c72

Amoebicidal Effect of COVID Box Molecules against Acanthamoeba: A Study of Cell Death

Authors: Ines Sifaoui, Rubén L. Rodríguez-Expósito, María Reyes-Batlle, Robert Sutak, José E. Piñero, Jacob Lorenzo-Morales

Source: Pharmaceuticals, Vol 17, Iss 6, p 808 (2024)

Subject Terms: COVID box, Acanthamoeba, amoebicidal activity, action mode, programmed cell death, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/6/808; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/f5c62066cae44a72b4a70ff49c6e3e4d

Inhibition of Acanthamoeba polyphaga by chlorhexidine-mediated oxidative stress response

Authors: Ines Sifaoui, Ikrame Zeouk, María Reyes-Batlle, Atteneri Lopez-Arencibia, José E. Piñero, Jacob Lorenzo-Morales

Source: Journal of Global Antimicrobial Resistance, Vol 30, Iss , Pp 468-473 (2022)

Subject Terms: Acanthamoeba polyphaga, Chlorhexidine, Antioxidant activity, Oxidative stress, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213716522001205; https://doaj.org/toc/2213-7165

Access URL: https://doaj.org/article/9d662ee6433b4777a7d5ff8888df84b2

Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline

Authors: Rubén L. Rodríguez-Expósito, Ines Sifaoui, María Reyes-Batlle, Frieder Fuchs, Patrick L. Scheid, José E. Piñero, Robert Sutak, Jacob Lorenzo-Morales

Source: Antioxidants, Vol 12, Iss 12, p 2081 (2023)

Subject Terms: Acanthamoeba, nitroxoline, programmed cell death, autophagy, cytoskeleton, proteomic analysis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/12/2081; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/f7a9a29866554be1b9194c164407d611

Antiamoeboid activity of squamins C–F, cyclooctapeptides from Annona globifora

Authors: Rubén L. Rodríguez-Expósito, Javier Sosa-Rueda, María Reyes-Batlle, Ines Sifaoui, Francisco Cen-Pacheco, Antonio Hernández Daranas, Ana R. Díaz-Marrero, José E. Piñero, José J. Fernández, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 67-79 (2021)

Subject Terms: Squamin, Cyclopeptide, Acanthamoeba, Annona, Antiamoeboid, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320721000397; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/54ea6c95391b4e5c96c095e0852e08f1

The therapeutic potential of novel isobenzofuranones against Naegleria fowleri

Authors: Aitor Rizo-Liendo, Iñigo Arberas-Jiménez, Ines Sifaoui, Dimitra Gkolfi, Yiset Santana, Leandro Cotos, David Tejedor, Fernando García-Tellado, José E. Piñero, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 139-149 (2021)

Subject Terms: Naegleria, Therapeutics, Isobenzofuranones, Programmed cell death, Encephalitis, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320721000476; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/6348baa2cf7d484d8384ea15a9a36920

Ultraviolet – Chlorine combined treatment efficiency to eliminate Naegleria fowleri in artificial surf lagoons

Authors: Iñigo Arberas-Jiménez, Ines Sifaoui, María Reyes-Batlle, Aitor Rizo-Liendo, Luis Sancho, Andoni Urruticoechea, José E. Piñero, Jacob Lorenzo-Morales

Source: Heliyon, Vol 8, Iss 11, Pp e11625- (2022)

Subject Terms: Free-living amoeba, Naegleria fowleri, cove lagoon, UV light, Chlorination, Disinfection, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844022029139; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/604d609b733d41fbb3ec18b62b08c2ea

Repurposing of Nitroxoline as an Alternative Primary Amoebic Meningoencephalitis Treatment

Authors: Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Frieder Fuchs, Ines Sifaoui, José E. Piñero, Jacob Lorenzo-Morales, Patrick Scheid

Source: Antibiotics, Vol 12, Iss 8, p 1280 (2023)

Subject Terms: Naegleria fowleri, primary amoebic meningoencephalitis, drug repurposing, Nitroxoline, programmed cell death, 8-hydroxy-quinoline, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/12/8/1280; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/e7c3b7efb92649f0bdbb779d63bc7836

A Fluorometric Assay for the In Vitro Evaluation of Activity against Naegleria fowleri Cysts

Authors: Iñigo Arberas-Jiménez, Aitor Rizo-Liendo, Ines Sifaoui, Javier Chao-Pellicer, José E. Piñero, Jacob Lorenzo-Morales

Source: Microbiology Spectrum, Vol 10, Iss 4 (2022)

Subject Terms: antiamoebic activity, cyst, Naegleria, meningoencephalitis, protocol, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/e76a85b72569406aabc7d587b380022e

Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis

Authors: Olfa Chiboub, Ines Sifaoui, Manef Abderrabba, Mondher Mejri, José J. Fernández, Ana R. Díaz-Marrero, Jacob Lorenzo-Morales, José E. Piñero

Source: Parasites & Vectors, Vol 14, Iss 1, Pp 1-13 (2021)

Subject Terms: T. cruzi, L. amazonensis, Diterpenes, Marine compounds, Antikinetoplastid, Apoptosis-like, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/837ca87966d642e8a7e6c99eaeb84760

In vitro validation of the amoebicidal activity of commercial eye drops as second activity

Authors: Olfa Chiboub, Eulalia Capote-Yanes, Ines Sifaoui, María Reyes -Batlle, Rubén L. Rodríguez - Expósito, José E. Piñero, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss , Pp 144-151 (2021)

Subject Terms: Eye-drop, Acanthamoeba spp., Amoebicidal activity, PCD, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320721000105; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/a6497a17a2b7472b9caba9db2a7ba51b

In vitro evaluation of commercial foam Belcils® on Acanthamoeba spp

Authors: Ines Sifaoui, Iván Rodríguez-Talavera, María Reyes-Batlle, Rubén L. Rodríguez-Expósito, Pedro Rocha-Cabrera, José E. Piñero, Jacob Lorenzo-Morales

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 136-143 (2020)

Subject Terms: Belcils® foam, Acanthamoeba spp., Amoebicidal activity, PCD, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320720300336; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/551c1149dc39424991425f072d8107a1

Marine Meroterpenoids Isolated from Gongolaria abies-marina Induce Programmed Cell Death in Naegleria fowleri

Authors: Iñigo Arberas-Jiménez, Rubén L. Rodríguez-Expósito, Desirée San Nicolás-Hernández, Javier Chao-Pellicer, Ines Sifaoui, Ana R. Díaz-Marrero, José J. Fernández, José E. Piñero, Jacob Lorenzo-Morales

Source: Pharmaceuticals, Vol 16, Iss 7, p 1010 (2023)

Subject Terms: meroterpenoids, marine natural products, Gongolaria abies-marina, Naegleria fowleri, meningoencephalitis, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/7/1010; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/0b248db353de44ce8fc683de238a1893

Chamigrane-Type Sesquiterpenes from Laurencia dendroidea as Lead Compounds against Naegleria fowleri

Authors: Iñigo Arberas-Jiménez, Nathália Nocchi, Javier Chao-Pellicer, Ines Sifaoui, Angélica Ribeiro Soares, Ana R. Díaz-Marrero, José J. Fernández, José E. Piñero, Jacob Lorenzo-Morales

Source: Marine Drugs, Vol 21, Iss 4, p 224 (2023)

Subject Terms: elatol, marine chamigrane, sesquiterpenes, Naegleria fowleri, Laurencia dendroidea, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/21/4/224; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/452ea13537e548dabf717082484099f0

Meroterpenoids from Gongolaria abies-marina against Kinetoplastids: In Vitro Activity and Programmed Cell Death Study

Authors: Desirée San Nicolás-Hernández, Rubén L. Rodríguez-Expósito, Atteneri López-Arencibia, Carlos J. Bethencourt-Estrella, Ines Sifaoui, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, José J. Fernández, Ana R. Díaz-Marrero, José E. Piñero, Jacob Lorenzo-Morales

Source: Pharmaceuticals, Vol 16, Iss 4, p 476 (2023)

Subject Terms: Gongolaria abies-marina, Leishmania, Trypanosoma cruzi, chemotherapy, meroterpenoids, apoptosis-like, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/4/476; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/ce386cec46294a6586737ddc06cc35a3