Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia

Authors: Tongting Ji, Yang Yang, Juanjuan Yu, Hongli Yin, Xinran Chu, Pengju Yang, Ling Xu, Xiaodong Wang, Shaoyan Hu, Yizhen Li, Xiaochen Wu, Wengyuan Liu, Bi Zhou, Wenjuan Wang, Shuqi Zhang, Wei Cheng, Yanling Chen, Lei Shi, Zhiheng Li, Ran Zhuo, Yongping Zhang, Yanfang Tao, Di Wu, Xiaolu Li, Zimu Zhang, Jun-jie Fan, Jian Pan, Jun Lu

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)

Subject Terms: Indisulam, RBM39, T-ALL, RNA splicing, THOC1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/fe8dbc62f5da40a89726b93bc9a83c7e

Elucidation of the interaction between apo-transferrin and indisulam via multi-spectroscopic techniques and molecular modeling

Authors: Zhang, Qiumei ^a, Zhang, Yue ^b, Zhang, Shuyuan ^a, Zeng, Yujing ^b, He, Zimeng ^a, Yang, Kaiyu ^b, Luo, Jiaqing ^a, Guo, Hui ^a, Chi, Baozhu ^{a, ⁎}

Source: In Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 5 April 2025 330

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Authors: Lisa Arnet, Lisabeth Emilius, Annett Hamann, Maria Carmo-Fonseca, Carola Berking, Jan Dörrie, Niels Schaft

Source: Pharmaceutics, Vol 17, Iss 3, p 368 (2025)

Subject Terms: indisulam (E7070), neoantigens, immunotherapy, T cells, dendritic cells, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/3/368; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/dfe0a88be31548949ee7afbf2c268341

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

Authors: Carolyn M Jablonowski, Waise Quarni, Shivendra Singh, Haiyan Tan, Dhanushka Hewa Bostanthirige, Hongjian Jin, Jie Fang, Ti-Cheng Chang, David Finkelstein, Ji-Hoon Cho, Dongli Hu, Vishwajeeth Pagala, Sadie Miki Sakurada, Shondra M Pruett-Miller, Ruoning Wang, Andrew Murphy, Kevin Freeman, Junmin Peng, Andrew M Davidoff, Gang Wu, Jun Yang

Source: eLife, Vol 12 (2024)

Subject Terms: JMJD6, GLS, neuroblastoma, splicing, indisulam, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/90993; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/56c3296c6a1943a796dba4f0a49cdf21

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CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure of higher risk of severe hematologic malignancy.

Source: Journal of Clinical Pharmacology. Dec2007, Vol. 47 Issue 12, p1592-1592. 2/3p.

Subject Terms: *HEMATOLOGY, *NONFICTION

Reviews & Products: CYP2C9 & CYP2C19 Polymorphic Forms Are Related to Increased Indisulam Exposure of Higher Risk of Severe Hematologic Malignancy (Book)

People: ZANDVLIET, A. S., HUITEMA, A. D. R., COPALU, W.

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