Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches

Authors: Lufei Yang, Jiawei Gui, Yilei Sheng, Junzhe Liu, Chong Wang, Zhansheng Fang, Le Huang, Zewei Tu, Xingen Zhu, Kai Huang

Source: European Journal of Medical Research, Vol 30, Iss 1, Pp 1-19 (2025)

Subject Terms: Immunotherapy response, Molecular docking, Pan-cancer, Prognostic biomarker, TAP2, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/dc1583078e5946e1b1e1d9b9733cd603

Single-cell transcriptomic analyses reveal heterogeneity and key subsets associated with survival and response to PD-1 blockade in cervical squamous cell carcinoma

Authors: Xia Li, Zhao Zhao, Yanmei Cheng, Jiaqin Yan, Fang Ren, Yanyan Jia, Juanhua Li, Binhui Wang, Junqi Liu, Chenyin Wang, Meimei Gao, Hao Gu, Mingliang Fan, Huirong Shi, Mei Ji, Qitai Zhao

Source: Cancer Cell International, Vol 25, Iss 1, Pp 1-21 (2025)

Subject Terms: Cervical squamous cell carcinoma, Single-cell RNA sequencing, Heterogeneity, Tumor-associated epithelial cells, Immunotherapy response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

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Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/2daec59af5324bd9858b97193b17a44e

Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer

Authors: Xiaoyu Qin, Wenjuan Xu, Jinxiu Wu, Ming Li

Source: Discover Oncology, Vol 16, Iss 1, Pp 1-16 (2025)

Subject Terms: Colorectal cancer, Natural killer cells, ScRNA-seq, Immunotherapy response, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/3d6f73f24804497eace2618ed4a03a8a

The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications

Authors: Yue Gu, Miaosen Zheng, Jing Xie

Source: Discover Oncology, Vol 16, Iss 1, Pp 1-13 (2025)

Subject Terms: Non-small cell lung cancer (NSCLC), MRO, M2 macrophages, Tumor microenvironment, Immunotherapy response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/ed7059a6c0e046a5abac73c08e903e66

MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress

Authors: Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

Source: Journal of Inflammation Research, Vol Volume 18, Pp 601-619 (2025)

Subject Terms: nash, map17, macrophage infiltration, immunotherapy response, oxidative stress, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/map17-is-a-novel-nash-progression-biomarker-associated-with-macrophage-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/eb2c7269d50b47c68ef31904c9973894

Exploring FNDC4 as a biomarker for prognosis and immunotherapy response in lung adenocarcinoma

Authors: Shengshan Xu, Zhuming Lu

Source: Asian Journal of Surgery, Vol 48, Iss 3, Pp 1799-1801 (2025)

Subject Terms: FNDC4, Biomarker, Prognosis, Immunotherapy response, Lung adenocarcinoma, Surgery, RD1-811

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1015958424020980; https://doaj.org/toc/1015-9584

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Identification of gastric cancer subtypes based on disulfidptosis-related genes: GPC3 as a novel biomarker for prognosis prediction

Authors: Nan Yi, Xindong Yin, Xiao Feng, Ming Ren, Chaoqun Ma

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)

Subject Terms: Disulfidptosis, Gastric cancer, Prognosis, GPC3, Immunotherapy response, Drug sensitivity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/11a778d00ef4443b878626785266f05d

Lipid metabolism subtypes reflects the prognosis and immune profiles of bladder cancer patients by NMF clustering and building related signature

Authors: Zhongbao Zhou, Yumeng Chai, Yulong Li, Yong Zhang, Tao Wang

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Lipid metabolism, Bladder cancer, NMF clustering, Immunotherapy response, Prognosis, Signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/a51c2568107c4d7ebc92dbd9307713e5

Integration of Graph Neural Networks and multi-omics analysis identify the predictive factor and key gene for immunotherapy response and prognosis of bladder cancer

Authors: Shuai Ren, Yongjian Lu, Guangping Zhang, Ke Xie, Danni Chen, Xiangna Cai, Maodong Ye

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Bladder cancer, Immunotherapy response, Prognosis, Graph Neural Networks, Bioinformatics, Tumor microenvironment, Medicine

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Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/71e4c87808814c8f8e9bc9f89f5a657f

DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis

Authors: Mi Zou, Zuxi Feng, Kaibo Hu, Yuan Shu, Ting Li, Xiaogang Peng, Leifeng Chen, Leyang Xiao, Shouhua Zhang, Ting Xiong, Xueqiang Deng, Jie Peng, Liang Hao

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: DCLRE1B, Pancancer, Prognostic biomarker, Immunotherapy response, Prognosis, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/bf120885b659497aa9cce7e2f1da71a5

TDERS, an exosome RNA-derived signature predicts prognosis and immunotherapeutic response in clear cell renal cell cancer: a multicohort study

Authors: Aimin Jiang, Ying Liu, Ziwei He, Wenqiang Liu, Qiwei Yang, Yu Fang, Baohua Zhu, Xiaofeng Wu, Huamao Ye, Bicheng Ye, Shunxiang Gao, Le Qu, Wenhao Xu, Peng Luo, Linhui Wang

Source: Journal of the National Cancer Center, Vol 4, Iss 4, Pp 382-394 (2024)

Subject Terms: Renal cell carcinoma, Exosome, Non-invasive biopsy, Immunotherapy response, Multiomics, PLOD2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667005424000802; https://doaj.org/toc/2667-0054

Access URL: https://doaj.org/article/4f932dfcf07f46678393efee5252362f

Inflammatory response signature score model for predicting immunotherapy response and pan-cancer prognosis

Authors: Shuzhao Chen, Mayan Huang, Limei Zhang, Qianqian Huang, Yun Wang, Yang Liang

Source: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 369-383 (2024)

Subject Terms: Cancer immunotherapy response, Inflammatory response, Tumor immunity, Biomarker, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023004762; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/cfd35057a92d4a6da050cbbb1d9a7d5d

The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma

Authors: Meng Yang, Dan He, Yu Sun, Yunquan Guo, Yu Ma, Lin Feng, Meng Liu

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Subject Terms: T cell receptor repertoire, Immunotherapy response, Esophageal squamous cell carcinoma, Overall survival, Medicine

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Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/cbff68607cde4c7eb4022dd69fc6cb51

Pan-cancer analysis of oncogenic role of CEP55 and experiment validation in clear cell renal cell carcinoma

Authors: Libin zhou, Yimeng Zhu, Fei Guo, Huimin Long, Min Yin

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: CEP55, ccRCC, Pan-cancer analysis, Immune infiltration, Immunotherapy response, Proliferation markers, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/452b6cae713c46a299a151bf4057d546

Investigating PPT2’s role in ovarian cancer prognosis and immunotherapy outcomes

Authors: Hui Xu, Yan Zhang, Zhen Xie, Xiao-feng Xie, Wen-lan Qiao, Miao Wang, Bei-bei Zhao, Tian Hua

Source: Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-17 (2024)

Subject Terms: PPT2, Ovarian cancer, Prognosis, Immunotherapy response, Tumor microenvironment, Gynecology and obstetrics, RG1-991

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Relation: https://doaj.org/toc/1757-2215

Access URL: https://doaj.org/article/7e2c798848044445a32172a8f0265061

Pan-cancer analysis of Sp1 with a focus on immunomodulatory roles in gastric cancer

Authors: Yang Zhou, Zhenzhen Luo, Jinfeng Guo, Lixia Wu, Xiaoli Zhou, Jun Jie Huang, Daijia Huang, Li Xiao, Qiuhua Duan, Jianhua Chang, Libao Gong, Junjie Hang

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)

Subject Terms: Sp1, Pan-cancer analysis, Prognosis, Immunotherapy response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

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Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/243f3bc470d742bbaedd27025ce9266c

Machine‐learning‐based integration of tumor microenvironment features predicting immunotherapy response

Authors: Kunpeng Luo, Shuqiang Liu, Yunfu Cui, Jinglin Li, Xiuyun Shen, Jincheng Xu, Yanan Jiang

Source: MedComm – Future Medicine, Vol 4, Iss 1, Pp n/a-n/a (2025)

Subject Terms: immunotherapy response, machine‐learning, pan‐cancer, tumor microenvironment, Medical technology, R855-855.5, Computer applications to medicine. Medical informatics, R858-859.7

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Relation: https://doaj.org/toc/2769-6456

Access URL: https://doaj.org/article/0cebe77df2764bcba93a1a8016b7ce08

Variations in salivary microbiome and metabolites are associated with immunotherapy efficacy in patients with advanced NSCLC

Authors: DanHui Huang, YueHua Chen, Cui Li, Shuang Yang, LiShan Lin, XiaoNan Zhang, XiaoFang Su, LaiYu Liu, Haijin Zhao, Tingyue Luo, Shaoxi Cai, QianNan Ren, Hangming Dong

Source: mSystems, Vol 10, Iss 3 (2025)

Subject Terms: saliva microbiome, fat metabolism, immunotherapy response, non-small cell lung cancer, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/775e8545d90240b7b8c8ea59571b3099

Multimodal deep learning for predicting PD-L1 biomarker and clinical immunotherapy outcomes of esophageal cancer

Authors: Hui Liu, Yinpu Bai, Zhidong Wang, Shi Yin, Cheng Gong, Bin Wang

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: esophageal squamous cell carcinoma, PD-L1 biomarker, multi-modal deep learning, immunotherapy response, pathology image, CT imaging, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540013/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/83b8ca5079da4c46ab29b1b742f8176c

Editorial: Unveiling biomarkers and mechanisms in the tumor-immune nexus

Authors: Chenfeng Ma, Wantao Wu, Pengpeng Zhang, Jiaheng Xie

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: immunotherapy response biomarkers, tumor-immune interactions, immune evasion mechanisms, tumor microenvironment, next-generation sequencing technologies, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581492/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d95afda8397b4fe0aaa80b8460a6f6d0