Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives

Authors: Lista, Simone ^{a, ⁎}, Munafò, Antonio ^b, Caraci, Filippo ^{c, d}, Imbimbo, Camillo ^e, Emanuele, Enzo ^f, Minoretti, Piercarlo ^g, Pinto-Fraga, José ^a, Merino-País, María ^a, Crespo-Escobar, Paula ^a, López-Ortiz, Susana ^a, Monteleone, Giovanni ^{h, i}, Imbimbo, Bruno P. ^j, Santos-Lozano, Alejandro ^{a, k}

Source: In Ageing Research Reviews February 2025 104

Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression

Authors: Reichert Plaska, Chelsea, Heslegrave, Amanda, Bruno, Davide, Ramos-Cejudo, Jaime, Han Lee, Sang, Osorio, Ricardo, Imbimbo, Bruno P., Zetterberg, Henrik, Blennow, Kaj, Pomara, Nunzio

Source: In Brain Behavior and Immunity August 2024 120:248-255

Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?

Authors: Lista, Simone¹ (AUTHOR) slista@uemc.es, Imbimbo, Bruno P.² (AUTHOR), Grasso, Margherita³ (AUTHOR), Fidilio, Annamaria³ (AUTHOR), Emanuele, Enzo⁴ (AUTHOR), Minoretti, Piercarlo⁵ (AUTHOR), López-Ortiz, Susana¹ (AUTHOR), Martín-Hernández, Juan¹ (AUTHOR), Gabelle, Audrey⁶ (AUTHOR), Caruso, Giuseppe^3,7 (AUTHOR), Malaguti, Marco⁸ (AUTHOR), Melchiorri, Daniela⁹ (AUTHOR), Santos-Lozano, Alejandro^1,10 (AUTHOR), Imbimbo, Camillo¹¹ (AUTHOR), Heneka, Michael T.¹² (AUTHOR) michael.heneka@uni.lu, Caraci, Filippo^3,7 (AUTHOR) fcaraci@unict.it

Source: Journal of Neuroinflammation. 7/30/2024, Vol. 21 Issue 1, p1-24. 24p.

Plasma ATN(I) classification and precision pharmacology in Alzheimer's disease

Authors: Imbimbo, Bruno P., Watling, Mark, Imbimbo, Camillo, Nisticò, Robert

Source: Alzheimer's & dementia. 19(10):4729-4734

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195333405.0x000001&indx=1&recIds=ETOCvdc_100195333405.0x000001

Integrative metabolomics science in Alzheimer’s disease: Relevance and future perspectives

Authors: Lista, Simone, González-Domínguez, Raúl, López-Ortiz, Susana, González-Domínguez, Álvaro, Menéndez, Héctor, Martín-Hernández, Juan, Lucia, Alejandro, Emanuele, Enzo, Centonze, Diego, Imbimbo, Bruno P., Triaca, Viviana, Lionetto, Luana, Simmaco, Maurizio, Cuperlovic-Culf, Miroslava, Mill, Jericha, Li, Lingjun, Mapstone, Mark, Santos-Lozano, Alejandro, Nisticò, Robert

Source: In Ageing Research Reviews August 2023 89

Role of monomeric amyloid-β in cognitive performance in Alzheimer's disease: Insights from clinical trials with secretase inhibitors and monoclonal antibodies

Authors: Imbimbo, Bruno P., Ippati, Stefania, Watling, Mark, Imbimbo, Camillo

Source: In Pharmacological Research January 2023 187

A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

Authors: Imbimbo, Bruno P., Ippati, Stefania, Watling, Mark, Balducci, Claudia

Source: Alzheimer's & dementia. 18(5):1008-1037

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149900119.0x000001&indx=1&recIds=ETOCvdc_100149900119.0x000001

Beneficial effects of CHF6467, a modified human nerve growth factor, in experimental neonatal hypoxic–ischaemic encephalopathy.

Authors: Landucci, Elisa, Mango, Dalila, Carloni, Silvia, Mazzantini, Costanza, Pellegrini‐Giampietro, Domenico E., Saidi, Amira, Balduini, Walter, Schiavi, Elisa, Tigli, Laura, Pioselli, Barbara, Imbimbo, Bruno P., Facchinetti, Fabrizio

Source: British Journal of Pharmacology; Feb2025, Vol. 182 Issue 3, p510-529, 20p

Subject Terms: NERVE growth factor, LABORATORY rats, INTRANASAL administration, THERAPEUTIC hypothermia, BRAIN damage

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Authors: Pini, Lorenzo, Lista, Simone, Griffa, Alessandra, Allali, Gilles, Imbimbo, Bruno P

Source: Brain Communications; 2025, Vol. 7 Issue 1, p1-12, 12p

Evidence of upregulation of the cholinergic anti-inflammatory pathway in late-life depression

Authors: Pomara, Nunzio, Bruno, Davide, Plaska, Chelsea Reichert, Pillai, Anilkumar, Ramos-Cejudo, Jaime, Osorio, Ricardo, Imbimbo, Bruno P., Heslegrave, Amanda, Zetterberg, Henrik, Blennow, Kaj

Source: In Journal of Affective Disorders 1 May 2021 286:275-281

Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism

Authors: Panza, Francesco, Lozupone, Madia, Watling, Mark, Imbimbo, Bruno P.

Source: Expert opinion on pharmacotherapy. 22(3):325-337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120276631.0x000001&indx=1&recIds=ETOCvdc_100120276631.0x000001

What have we learned from past failures of investigational drugs for Alzheimer's disease?

Authors: Imbimbo, Bruno P., Watling, Mark

Source: Expert opinion on investigational drugs. 30(12):1175-1182

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139232824.0x000001&indx=1&recIds=ETOCvdc_100139232824.0x000001

Accelerating Alzheimer's disease drug discovery and development: what's the way forward?

Authors: Imbimbo, Bruno P., Ippati, Stefania, Watling, Mark, Balducci, Claudia

Source: Expert opinion on drug discovery. 16(7):727-735

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122427396.0x000001&indx=1&recIds=ETOCvdc_100122427396.0x000001

Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer's disease trials.

Authors: Abanto, Jesus¹, Dwivedi, Alok K², Imbimbo, Bruno P³, Espay, Alberto J¹, alberto.espay@uc.edu

Source: Brain: A Journal of Neurology; Oct2024, Vol. 147 Issue 10, p3513-3521, 9p

Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Authors: Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaut, Vergallo, Andrea, Younsi, Nadjia, Afshar, Mohammad, Aguilar, Lisi Flores, Akman-Anderson, Leyla, Arenas, Joaquín, Ávila, Jesús, Babiloni, Claudio, Baldacci, Filippo, Batrla, Richard, Benda, Norbert, Black, Keith L., Bokde, Arun L.W., Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Caraci, Filippo, Caruso, Giuseppe, Castrillo†, Juan, Ceravolo, Roberto, Chiesa, Patrizia A., Corbo, Massimo, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Emanuele, Enzo, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, Geerts, Hugo, Giacobini, Ezio, Giorgi, Filippo S., Goetzl, Edward J., Graziani, Manuela, Haberkamp, Marion, Hänisch, Britta, Herholz, Karl, Hernandez, Felix, Imbimbo, Bruno P., Kapogiannis, Dimitrios, Karran, Eric, Kiddle, Steven J., Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lemercier, Pablo, Llavero, Francisco, Lorenceau, Jean, Lucía, Alejandro, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticò, Robert, O’bryant, Sid E., Palermo, Giovanni, Perry, George, Ritchie, Craig, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Valenzuela, Pedro L., Vellas, Bruno, Verdooner, Steven R., Villain, Nicolas, Giudici, Kelly Virecoulon, Watling, Mark, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan, Zugaza, José L., Zetterberg, Henrik, Blennow, Kaj

Source: In Neurobiology of Aging December 2020 96:22-32

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Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin

Authors: Loconte, Valentina, Menozzi, Ilaria, Ferrari, Alberto, Folli, Claudia, Imbimbo, Bruno P., Zanotti, Giuseppe, Berni, Rodolfo

Source: In Journal of Structural Biology 1 November 2019 208(2):165-173

Discontinued disease-modifying therapies for Alzheimer's disease: status and future perspectives

Authors: Imbimbo, Bruno P., Lozupone, Madia, Watling, Mark, Panza, Francesco

Source: Expert opinion on investigational drugs. 29(9):919-933

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110698924.0x000001&indx=1&recIds=ETOCvdc_100110698924.0x000001

Are we close to using Alzheimer blood biomarkers in clinical practice.

Authors: Imbimbo, Bruno P., Lista, Simone, Imbimbo, Camillo, Nisticò, Robert

Source: Neural Regeneration Research; Dec2024, Vol. 19 Issue 12, p2583-2585, 3p

Investigational BACE inhibitors for the treatment of Alzheimer's disease

Authors: Imbimbo, Bruno P., Watling, Mark

Source: Expert opinion on investigational drugs. 28(11):967-975

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091511009.0x000001&indx=1&recIds=ETOCvdc_100091511009.0x000001