Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury

Authors: Kenshin Shimono, Takashi Ito, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Hirokazu Onishi, Hideaki Yoshihara, Ikuro Maruyama, Yasuyuki Kakihana

Source: Thrombosis Journal, Vol 21, Iss 1, Pp 1-9 (2023)

Subject Terms: Damage-associated molecular patterns (DAMPs), Trauma-induced coagulopathy, Histone H3, Plasmin-α2-PI complex (PIC), Plasminogen activator inhibitor-1 (PAI-1), Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/143e0f6f3bf446d59c4cf6e14e30df40

Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study

Authors: Shotaro Otsuka, Kiyoshi Kikuchi, Yasufumi Takeshita, Seiya Takada, Akira Tani, Harutoshi Sakakima, Ikuro Maruyama, Hyuma Makizako

Source: Frontiers in Aging Neuroscience, Vol 16 (2024)

Subject Terms: aging, depressive symptoms, memory problems, physical activity, interleukin 6 (IL-6), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1337397/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/43e1319744f2437f954ed93cb5fa40f6

Ninjin'yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice.

Authors: Shotaro Otsuka, Ryoma Matsuzaki, Shogo Kakimoto, Yuta Tachibe, Takuya Kawatani, Seiya Takada, Akira Tani, Kazuki Nakanishi, Teruki Matsuoka, Yuki Kato, Masaki Inadome, Nao Nojima, Harutoshi Sakakima, Keita Mizuno, Yosuke Matsubara, Ikuro Maruyama

Source: PLoS ONE, Vol 19, Iss 5, p e0303833 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303833&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c10b922abb56447f9d3b1ff57b6e1fcf

Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats

Authors: Shotaro Otsuka, Yuki Itashiki, Akira Tani, Teruki Matsuoka, Seiya Takada, Ryoma Matsuzaki, Kazuki Nakanishi, Kosuke Norimatsu, Yuta Tachibe, Riho Kitazato, Nao Nojima, Shogo Kakimoto, Kiyoshi Kikuchi, Ikuro Maruyama, Harutoshi Sakakima

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/523843cb5ec0470d881029aa91ff1134

An evaluation of circulating activated TAFI in septic DIC: a case series and review of the literature

Authors: Takaaki Totoki, Takashi Ito, Midori Kakuuchi, Nozomi Yashima, Ikuro Maruyama, Yasuyuki Kakihana

Source: Thrombosis Journal, Vol 20, Iss 1, Pp 1-5 (2022)

Subject Terms: Disseminated intravascular coagulation, Thrombin-activatable fibrinolysis inhibitor, Sepsis, Thrombomodulin, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/bd2206a6bbb041968c43447f08d1634f

Cardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals: analysis using the Total Thrombus-formation Analysis System

Authors: Yuu Oda, Takashi Ito, Yoichiro Yamada, Tadashi Koga, Tomoka Nagasato, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Hiroyuki Fukase, Teruto Hashiguchi, Ikuro Maruyama

Source: Thrombosis Journal, Vol 19, Iss 1, Pp 1-8 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/afcc605569cc4ab09c03871aa8bed96c

Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

Authors: Takashi Ito, Takaaki Totoki, Seiya Takada, Shotaro Otsuka, Ikuro Maruyama

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/092798094f4d4f168e83758f5e9d5e42

Specific detection of high mobility group box 1 degradation product with a novel ELISA

Authors: Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori, Ikuro Maruyama

Source: Molecular Medicine, Vol 27, Iss 1, Pp 1-8 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1076-1551; https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/06a6f482f8fb4460b4d149a4f587ae52

Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation

Authors: Takashi Ito, Midori Kakuuchi, Ikuro Maruyama

Source: Critical Care, Vol 25, Iss 1, Pp 1-9 (2021)

Subject Terms: Sepsis, Disseminated intravascular coagulation (DIC), Endotheliopathy, Extracellular histones, Lipopolysaccharide (LPS), Antithrombin, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/f33ec10be4064b0790534c27fe1918c0

A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia

Authors: Bengo Atari, Takashi Ito, Tomoka Nagasato, Tomoko Ohnishi, Kazuya Hosokawa, Tomotsugu Yasuda, Ikuro Maruyama, Yasuyuki Kakihana

Source: Thrombosis Journal, Vol 18, Iss 1, Pp 1-9 (2020)

Subject Terms: Thrombocytopenia, Platelet transfusion, Bleeding, Flow chamber, Total Thrombus-formation analysis system (T-TAS), Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12959-020-00244-9; https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/391c1b0585ec439bb2b16d37325a12e7

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Authors: Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito

Source: Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1141-1149 (2020)

Subject Terms: disseminated intravascular coagulation, heparin, protein C, thrombin, thrombomodulin, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/d5ebd439b6bc4e76827a7b06f5e957e1

Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study

Authors: Takashi Ito, Takaaki Totoki, Yayoi Yokoyama, Tomotsugu Yasuda, Hiroaki Furubeppu, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana

Source: Journal of Intensive Care, Vol 7, Iss 1, Pp 1-7 (2019)

Subject Terms: Sepsis, Disseminated Intravascular coagulation (DIC), Diagnosis, Histone, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2052-0492

Access URL: https://doaj.org/article/555b3bbba69d4ed781362a6bd196d2cf

Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

Authors: Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama, Yoshihiko Nishio

Source: Thrombosis Journal, Vol 17, Iss 1, Pp 1-9 (2019)

Subject Terms: Glycemic control, Hyperglycemia, Hypoglycemia, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12959-019-0206-8; https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/b7e127f07c8a4896bddf09f72214430d

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

Authors: Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Subject Terms: sepsis, glycocalyx, syndecan 1, thrombocytopenia, endotheliopathy, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.730553/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/19e0edb065b444b4be541b99414f1dc2

Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury

Authors: Hiroaki Furubeppu, Takashi Ito, Midori Kakuuchi, Tomotsugu Yasuda, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: ischemia reperfusion injury, high mobility group box 1, extracellular histones, damage-associated molecular patterns, skeletal muscle, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.628822/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/72fdcbaf7abe45979e42857fe914c03c

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

Authors: Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana

Source: Thrombosis Journal, Vol 17, Iss 1, Pp 1-7 (2019)

Subject Terms: Histone, Sepsis, Coagulopathy, Organ failure, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12959-018-0190-4; https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/9500dc76080a4fc39bcb6df2819184d8

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

Authors: Takashi Ito, Mayumi Nakahara, Yoshiki Masuda, Sachie Ono, Shingo Yamada, Hiroyasu Ishikura, Hitoshi Imaizumi, Chinatsu Kamikokuryo, Yasuyuki Kakihana, Ikuro Maruyama

Source: Journal of Intensive Care, Vol 6, Iss 1, Pp 1-6 (2018)

Subject Terms: Histone, Sepsis, Neutrophil, ELISA, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40560-018-0348-y; https://doaj.org/toc/2052-0492

Access URL: https://doaj.org/article/cac994eecd734d4cafc7ac2abd62f3b4

Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

Authors: Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana

Source: Thrombosis Journal, Vol 16, Iss 1, Pp 1-7 (2018)

Subject Terms: Disseminated intravascular coagulation, Protein C, Sepsis, Thrombomodulin, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12959-018-0178-0; https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/da843b2c0fd24c6f91b2e21f13318f91

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

Authors: Binita Shrestha, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: histone, NETs, thrombomodulin, thrombosis, neutrophil, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02535/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5158d3f6370f4301b3cb259c1dc5583e

Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation

Authors: Fuminori Namino MT, Munekazu Yamakuchi MD, PhD, Yasuhisa Iriki MD, Hideki Okui MD, Hitoshi Ichiki MD, Ryuichi Maenosono PhD, Naoya Oketani MD, PhD, Izumi Masamoto PhD, Masaaki Miyata MD, PhD, Masahisa Horiuchi MD, PhD, Teruto Hashiguchi MD, PhD, Mitsuru Ohishi MD, PhD, Ikuro Maruyama MD, PhD

Source: Clinical and Applied Thrombosis/Hemostasis, Vol 25 (2019)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1938-2723

Access URL: https://doaj.org/article/3457f807416e4881994b1c21467fe139