Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS

Authors: Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky

Source: eLife, Vol 13 (2024)

Subject Terms: noncanonical inflammasome, caspase-11, LPS, sepsis, caspase-1, pyroptosis, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/83725; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/9a7de7c6836d438db9bfd14207873e03

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection.

Authors: Tzvi Y Pollock, Víctor R Vázquez Marrero, Igor E Brodsky, Sunny Shin

Source: PLoS Pathogens, Vol 19, Iss 6, p e1010767 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/08fb8a122725426ab65a91afd75c952a

Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication.

Authors: Nawar Naseer, Marisa S Egan, Valeria M Reyes Ruiz, William P Scott, Emma N Hunter, Tabitha Demissie, Isabella Rauch, Igor E Brodsky, Sunny Shin

Source: PLoS Pathogens, Vol 18, Iss 1, p e1009718 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/6b598c8d660a4ecbb24d13321796015b

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.

Authors: Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky

Source: PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5

Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity.

Authors: Adriana R Mantegazza, Meghan A Wynosky-Dolfi, Cierra N Casson, Ariel J Lefkovith, Sunny Shin, Igor E Brodsky, Michael S Marks

Source: PLoS Pathogens, Vol 13, Iss 12, p e1006785 (2017)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/a5393564b7f14e059427fb46cb885d79

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.

Authors: Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott

Source: PLoS Pathogens, Vol 13, Iss 2, p e1006196 (2017)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/bf659d3cfad341d093c22b1295c01163

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

Authors: Naomi H Philip, Alexandra DeLaney, Lance W Peterson, Melanie Santos-Marrero, Jennifer T Grier, Yan Sun, Meghan A Wynosky-Dolfi, Erin E Zwack, Baofeng Hu, Tayla M Olsen, Anthony Rongvaux, Scott D Pope, Carolina B López, Andrew Oberst, Daniel P Beiting, Jorge Henao-Mejia, Igor E Brodsky

Source: PLoS Pathogens, Vol 12, Iss 10, p e1005910 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005910&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/f64d18916f2d4f71922dc3bc9241243c

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species.

Authors: Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos

Source: PLoS ONE, Vol 9, Iss 2, p e88398 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3914978?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a5230609c1094dafa055494f4eedb004

Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

Authors: Cierra N Casson, Alan M Copenhaver, Erin E Zwack, Hieu T Nguyen, Till Strowig, Bahar Javdan, William P Bradley, Thomas C Fung, Richard A Flavell, Igor E Brodsky, Sunny Shin

Source: PLoS Pathogens, Vol 9, Iss 6, p e1003400 (2013)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3675167?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/6e70af77061a43699f1f4317eb5ba2ba

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Authors: Ying Zheng, Sarit Lilo, Igor E Brodsky, Yue Zhang, Ruslan Medzhitov, Kenneth B Marcu, James B Bliska

Source: PLoS Pathogens, Vol 7, Iss 4, p e1002026 (2011)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3080847?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/07a1861ffb6f4fc885f2d56e48df4a53

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.

Authors: Igor E Brodsky, Ruslan Medzhitov

Source: PLoS Pathogens, Vol 4, Iss 5, p e1000067 (2008)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2361194?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/fe776af843a745a28cc84f00bf40c770

Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell

Authors: Bethan A. Wallbank, Ryan D. Pardy, Igor E. Brodsky, Christopher A. Hunter, Boris Striepen

Source: mBio, Vol 15, Iss 8 (2024)

Subject Terms: Cryptosporidium, apicomplexan parasites, epithelial cells, gastrointestinal infection, diarrhea, apoptosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/9590de29d671445582465bc47250772a

Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells

Authors: Jenna Zhang, Igor E. Brodsky, Sunny Shin

Source: mBio, Vol 14, Iss 5 (2023)

Subject Terms: Yersinia, inflammasome, intestinal epithelial cell, human innate immunity, host-pathogen interactions, macrophages, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/5182967a4e4046fa98ff4c6f0a9aa45e

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Authors: Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand

Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/09b6a96e862a47278fdf07e7af978602

Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation

Authors: Natasha Lopes Fischer, Sunny Shin, Igor E. Brodsky

Source: Cell Reports, Vol 34, Iss 10, Pp 108855- (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721001698; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/a35f0170fa7b4007b89bcd910f8fc1a8

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

Authors: Erin E. Zwack, Annelise G. Snyder, Meghan A. Wynosky-Dolfi, Gordon Ruthel, Naomi H. Philip, Melanie M. Marketon, Matthew S. Francis, James B. Bliska, Igor E. Brodsky

Source: mBio, Vol 6, Iss 1 (2015)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/7f64c014a5aa4c928925802ef24e358f

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

Authors: Lawton K. Chung, Naomi H. Philip, Valentina A. Schmidt, Antonius Koller, Till Strowig, Richard A. Flavell, Igor E. Brodsky, James B. Bliska

Source: mBio, Vol 5, Iss 4 (2014)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/b52107ccd381415e9be79f32f4afdd51