Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Authors: Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/326ae301e3024de2b6652801e0ebede8

An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma

Authors: Veronica Davalos, Claudia D. Lovell, Richard Von Itter, Igor Dolgalev, Praveen Agrawal, Gillian Baptiste, David J. Kahler, Elena Sokolova, Sebastian Moran, Laia Piqué, Eleazar Vega-Saenz de Miera, Barbara Fontanals-Cirera, Alcida Karz, Aristotelis Tsirigos, Chi Yun, Farbod Darvishian, Heather C. Etchevers, Iman Osman, Manel Esteller, Markus Schober, Eva Hernando

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8185f7446ad34fda88510e094a1353e3

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Authors: Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684

Modulating mitofusins to control mitochondrial function and signaling

Authors: Emmanouil Zacharioudakis, Bogos Agianian, Vasantha Kumar MV, Nikolaos Biris, Thomas P. Garner, Inna Rabinovich-Nikitin, Amanda T. Ouchida, Victoria Margulets, Lars Ulrik Nordstrøm, Joel S. Riley, Igor Dolgalev, Yun Chen, Andre J. H. Wittig, Ryan Pekson, Chris Mathew, Peter Wei, Aristotelis Tsirigos, Stephen W. G. Tait, Lorrie A. Kirshenbaum, Richard N. Kitsis, Evripidis Gavathiotis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/92fc0c999e924a40a5e55d06aabc43db

POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling

Authors: Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E. Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone

Source: The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)

Subject Terms: Cell biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/9914b8b0574846e7832524ad7f4fa02e

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

Authors: John P. Brabson, Tiffany Leesang, Yoon Sing Yap, Jingjing Wang, Minh Q. Lam, Byron Fang, Igor Dolgalev, Daniela A. Barbieri, Victoria Strippoli, Carolina P. Bañuelos, Sofia Mohammad, Peter Lyon, Sana Chaudhry, Dane Donich, Anna Swirski, Evan Roberts, Ivelisse Diaz, Daniel Karl, Helena Gomes Dos Santos, Ramin Shiekhattar, Benjamin G. Neel, Stephen D. Nimer, Ramiro E. Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino

Source: Cell Reports, Vol 42, Iss 1, Pp 112027- (2023)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723000384; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/5e49692c1c5545df90f0bdb82844b32f

Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Authors: Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fbf64e220d324d00ad2d20768841c89d

Siah2 control of T-regulatory cells limits anti-tumor immunity

Authors: Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b4571c9b4e094486a2056a1668569d65

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

Authors: Shuang Zhang, Igor Dolgalev, Tao Zhang, Hao Ran, Douglas A. Levine, Benjamin G. Neel

Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b39734610e54645b1f1c0d284b8d77c

A pan-cancer organoid platform for precision medicine

Authors: Brian M. Larsen, Madhavi Kannan, Lee F. Langer, Benjamin D. Leibowitz, Aicha Bentaieb, Andrea Cancino, Igor Dolgalev, Bridgette E. Drummond, Jonathan R. Dry, Chi-Sing Ho, Gaurav Khullar, Benjamin A. Krantz, Brandon Mapes, Kelly E. McKinnon, Jessica Metti, Jason F. Perera, Tim A. Rand, Veronica Sanchez-Freire, Jenna M. Shaxted, Michelle M. Stein, Michael A. Streit, Yi-Hung Carol Tan, Yilin Zhang, Ende Zhao, Jagadish Venkataraman, Martin C. Stumpe, Jeffrey A. Borgia, Ashiq Masood, Daniel V.T. Catenacci, Jeremy V. Mathews, Demirkan B. Gursel, Jian-Jun Wei, Theodore H. Welling, Diane M. Simeone, Kevin P. White, Aly A. Khan, Catherine Igartua, Ameen A. Salahudeen

Source: Cell Reports, Vol 36, Iss 4, Pp 109429- (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721008469; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/9e05120e2cf8481abf4978520140395c

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity

Authors: Igor Dolgalev, Anastasia N. Tikhonova

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: microenvironment, stromal – hematopoietic cells interactions, bone marrow, cell-to cell communication, hematopoiesis, single-cell RNA-seq (scRNA-seq), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.622519/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/cccc160bb7c74e0a89dc4ac57592f479

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

Authors: Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L. Stapleton, David Zagzag, Luis Chiriboga, Sharon L. Gardner, Jeffrey H. Wisoff, John G. Golfinos, David Capper, Volker Hovestadt, Marc K. Rosenblum, Dimitris G. Placantonakis, Sarah E. LeBoeuf, Thales Y. Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G. Eberhart, Stefan M. Pfister, David T. W. Jones, Matthias A. Karajannis

Source: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ead93584496f48eaacd71d7cac4d1501

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

Authors: Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J. Alvarado, Igor Dolgalev, Thomas V. Karathanos, Kabir Malkani, Chantal J.M. Van Opbergen, Joanne J.A. van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E. Morley, William A. Coetzee, Natalia A. Trayanova, Michael J. Ackerman, Toon A.B. van Veen, Hector H. Valdivia, Mario Delmar

Source: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4417834a57fb40c18499881ece963bc6

The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.

Authors: Carlos Robello, Doris Patricia Maldonado, Anna Hevia, Marina Hoashi, Paola Frattaroli, Valentina Montacutti, Adriana Heguy, Igor Dolgalev, Maricruz Mojica, Gregorio Iraola, Maria G Dominguez-Bello

Source: PLoS ONE, Vol 14, Iss 2, p e0212593 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ec474f8b4185462d9865a2abbc32265a

Correction: The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.

Authors: Carlos Robello, Doris Patricia Maldonado, Anna Hevia, Marina Hoashi, Paola Frattaroli, Valentina Montacutti, Adriana Heguy, Igor Dolgalev, Maricruz Mojica, Gregorio Iraola, Maria G Dominguez-Bello

Source: PLoS ONE, Vol 14, Iss 4, p e0215199 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6448866?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6304d9d8a3844d9d9533edf221d40b74

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Authors: Raffaella Di Micco, Barbara Fontanals-Cirera, Vivien Low, Panagiotis Ntziachristos, Stephanie K. Yuen, Claudia D. Lovell, Igor Dolgalev, Yoshiya Yonekubo, Guangtao Zhang, Elena Rusinova, Guillermo Gerona-Navarro, Marta Cañamero, Michael Ohlmeyer, Iannis Aifantis, Ming-Ming Zhou, Aristotelis Tsirigos, Eva Hernando

Source: Cell Reports, Vol 9, Iss 1, Pp 234-247 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714007311; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/637cc06e452f4f3b8354d8e5926294d6

SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

Authors: Mirjam Blattner, Daniel J. Lee, Catherine O'Reilly, Kyung Park, Theresa Y. MacDonald, Francesca Khani, Kevin R. Turner, Ya-Lin Chiu, Peter J. Wild, Igor Dolgalev, Adriana Heguy, Andrea Sboner, Sinan Ramazangolu, Haley Hieronymus, Charles Sawyers, Ashutosh K. Tewari, Holger Moch, Ghil Suk Yoon, Yong Chul Known, Ove Andrén, Katja Fall, Francecsa Demichelis, Juan Miguel Mosquera, Brian D. Robinson, Christopher E. Barbieri, Mark A. Rubin

Source: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 1, Pp 14-20 (2014)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558614800031; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/e70e60f8f1924e34a239f67a165c3960

DangerTrack: A scoring system to detect difficult-to-assess regions [version 1; referees: 2 approved, 1 approved with reservations]

Authors: Igor Dolgalev, Fritz Sedlazeck, Ben Busby

Source: F1000Research, Vol 6 (2017)

Subject Terms: Bioinformatics, Genomics, Medicine, Science

File Description: electronic resource

Relation: https://f1000research.com/articles/6-443/v1; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/8717b42848e3423095671af281650c70

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures.

Authors: Marissa J Schafer, Igor Dolgalev, Melissa J Alldred, Adriana Heguy, Stephen D Ginsberg

Source: PLoS ONE, Vol 10, Iss 7, p e0133923 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5964c98bc34d4dc7adb1bb7af98e15b3

Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.

Authors: Sachin Jhawar, Prabhjot Singh, Daniel Torres, Francisco Ramirez-Valle, Hania Kassem, Trina Banerjee, Igor Dolgalev, Adriana Heguy, Jiri Zavadil, Jerome Lowenstein

Source: PLoS ONE, Vol 10, Iss 3, p e0118703 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4374671?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8887cc23a89149948fd31d4123f87ac0