Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites

Authors: Trotta, Anna Maria, Tomassi, Stefano, Di Maiolo, Gaetana, Ieranò, Caterina, Vetrei, Cinzia, D'Alterio, Crescenzo, Merlino, Francesco, Messere, Anna, D'Aniello, Antonia, Del Bene, Alessandra, Mazzarella, Vincenzo, Roggia, Michele, Natale, Benito, Cutolo, Roberto, Campagna, Erica, Mottola, Salvatore, Russo, Rosita, Chambery, Angela, Benedetti, Rosaria, Altucci, Lucia, Cosconati, Sandro, Scala, Stefania, Di Maro, Salvatore

Source: In European Journal of Medicinal Chemistry 5 October 2024 276

CXCL12-loaded-hydrogel (CLG): A new device for metastatic circulating tumor cells (CTCs) capturing and characterization

Authors: Portella, Luigi ^a, Bertolini, Giulia ^f, Guardascione, Giuseppe ^a, Di Febbraro, Dario Guido ^a, Ieranò, Caterina ^a, D'Alterio, Crescenzo ^a, Rea, Giuseppina ^a, Napolitano, Maria ^a, Santagata, Sara ^a, Trotta, Anna Maria ^a, Camerlingo, Rosa ^b, Scarpa, Emilia ^c, Cecere, Sabrina Chiara ^c, Ottaiano, Alessandro ^d, Palumbo, Giuliano ^e, Morabito, Alessandro ^e, Somma, Teresa ^g, De Rosa, Giuseppe ^h, Mayol, Laura ⁱ, Pacelli, Roberto ⁱ, Pignata, Sandro ^c, Scala, Stefania ^{a, ⁎}

Source: In Heliyon 15 August 2024 10(15)

The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells.

Authors: Russo, Daniela, Spina, Anna, Portella, Luigi, Bello, Anna Maria, Galdiero, Francesca, Trotta, Anna Maria, Ieranò, Caterina, Rea, Giuseppina, Cecere, Sabrina Chiara, Coppola, Elisabetta, Di Maro, Salvatore, Pignata, Sandro, Califano, Daniela, Scala, Stefania

Source: PLoS ONE; 12/19/2024, Vol. 19 Issue 12, p1-14, 14p

Subject Terms: CANCER cell proliferation, EPITHELIAL-mesenchymal transition, CANCER cell migration, OVARIAN cancer, STROMAL cell-derived factor 1

Disulfide Bond Replacement with 1, 4‐ and 1, 5‐Disubstituted [1, 2, 3]‐Triazole on C‐X‐C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences

Authors: Tomassi, Stefano, Trotta, Anna Maria, Ieranò, Caterina, Merlino, Francesco, Messere, Anna, Rea, Giuseppina, Santoro, Federica, Brancaccio, Diego, Carotenuto, Alfonso, D'Amore, Vincenzo Maria, Di Leva, Francesco Saverio, Novellino, Ettore, Cosconati, Sandro, Marinelli, Luciana, Scala, Stefania, Di Maro, Salvatore

Source: Chemistry. 26(44):10113-10125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107435674.0x000001&indx=1&recIds=ETOCvdc_100107435674.0x000001

Engineering of thermoresponsive gels as a fake metastatic niche

Authors: Giarra, Simona, Ierano, Caterina, Biondi, Marco, Napolitano, Maria, Campani, Virginia, Pacelli, Roberto, Scala, Stefania, De Rosa, Giuseppe, Mayol, Laura

Source: In Carbohydrate Polymers 1 July 2018 191:112-118

Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers

Authors: Tomassi, Stefano, Ieranò, Caterina, Mercurio, Maria Emilia, Nigro, Ersilia, Daniele, Aurora, Russo, Rosita, Chambery, Angela, Baglivo, Ilaria, Pedone, Paolo Vincenzo, Rea, Giuseppina, Napolitano, Maria, Scala, Stefania, Cosconati, Sandro, Marinelli, Luciana, Novellino, Ettore, Messere, Anna, Di Maro, Salvatore

Source: In Bioorganic & Medicinal Chemistry 15 May 2018 26(9):2539-2550

Tailoring the Structure of Cell Penetrating DNA and RNA Binding Nucleopeptides.

Authors: Tomassi, Stefano¹ (AUTHOR) stefano.tomassi@unina.it, Ieranò, Caterina² (AUTHOR) c.ierano@istitutotumori.na.it, Del Bene, Alessandra³ (AUTHOR) alessandra.delbene@unicampania.it, D'Aniello, Antonia³ (AUTHOR) antonia.daniello@unicampania.it, Napolitano, Maria² (AUTHOR) m.napolitano@istitutotumori.na.it, Rea, Giuseppina² (AUTHOR) g.rea@istitutotumori.na.it, Auletta, Federica² (AUTHOR) f.auletta@istitutotumori.na.it, Portella, Luigi² (AUTHOR) l.portella@istitutotumori.na.it, Capiluongo, Anna² (AUTHOR) a.capiluongo@istitutotumori.na.it, Mazzarella, Vincenzo³ (AUTHOR) vincenzo.mazzarella@studenti.unicampania.it, Russo, Rosita³ (AUTHOR) rosita.russo@unicampania.it, Chambery, Angela³ (AUTHOR) angela.chambery@unicampania.it, Scala, Stefania² (AUTHOR) s.scala@istitutotumori.na.it, Di Maro, Salvatore³ (AUTHOR) salvatore.dimaro@unicampania.it, Messere, Anna³ (AUTHOR) salvatore.dimaro@unicampania.it

Source: International Journal of Molecular Sciences. Aug2022, Vol. 23 Issue 15, p8504-8504. 14p.

Subject Terms: *PEPTIDE nucleic acids, *CELL anatomy, *DNA, *RNA, *AMINO acid residues

CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells

Authors: Ieranò, Caterina, D'Alterio, Crescenzo, Giarra, Simona, Napolitano, Maria, Rea, Giuseppina, Portella, Luigi, Santagata, Assunta, Trotta, Anna, Barbieri, Antonio, Campani, Virginia, Luciano, Antonio, Arra, Claudio, Anniciello, Anna, Botti, Gerardo, Mayol, Laura, Rosa, Giuseppe, Pacelli, Roberto, Scala, Stefania

Source: Cell death and disease. 10(8):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186583929.0x000001&indx=1&recIds=ETOCvdc_100186583929.0x000001

Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients.

Authors: Santagata, Sara, Rea, Giuseppina, Bello, Anna Maria, Capiluongo, Anna, Napolitano, Maria, Desicato, Sonia, Fragale, Alessandra, D'Alterio, Crescenzo, Trotta, Anna Maria, Ieranò, Caterina, Portella, Luigi, Persico, Francesco, Di Napoli, Marilena, Di Maro, Salvatore, Feroce, Florinda, Azzaro, Rosa, Gabriele, Lucia, Longo, Nicola, Pignata, Sandro, Perdonà, Sisto

Source: British Journal of Cancer; Jun2024, Vol. 130 Issue 12, p2016-2026, 11p

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

Authors: Fontanella, Raffaela, Pelagalli, Alessandra, Nardelli, Anna, D'Alterio, Crescenzo, Ieranò, Caterina, Cerchia, Laura, Lucarelli, Enrico, Scala, Stefania, Zannetti, Antonella ^*

Source: In Cancer Letters 1 January 2016 370(1):100-107

Hepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment.

Authors: Santagata, Sara, Rea, Giuseppina, Castaldo, Daniela, Napolitano, Maria, Capiluongo, Anna, D'Alterio, Crescenzo, Trotta, Anna Maria, Ieranò, Caterina, Portella, Luigi, Di Maro, Salvatore, Tatangelo, Fabiana, Albino, Vittorio, Guarino, Rita, Cutolo, Carmen, Izzo, Francesco, Scala, Stefania

Source: Hepatology International; Apr2024, Vol. 18 Issue 2, p568-581, 14p

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Authors: Liotti, Federica, Kumar, Narender, Prevete, Nella, Marotta, Maria, Sorriento, Daniela, Ieranò, Caterina, Ronchi, Andrea, Marino, Federica Zito, Moretti, Sonia, Colella, Renato, Puxeddu, Efiso, Paladino, Simona, Kano, Yoshihito, Ohh, Michael, Scala, Stefania, Melillo, Rosa Marina

Source: Journal of experimental & clinical cancer research. 40(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191094844.0x000001&indx=1&recIds=ETOCvdc_100191094844.0x000001

Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

Authors: D'Alterio, Crescenzo, Buoncervello, Maria, Ieranò, Caterina, Napolitano, Maria, Portella, Luigi, Rea, Giuseppina, Barbieri, Antonio, Luciano, Antonio, Scognamiglio, Giosuè, Tatangelo, Fabiana, Anniciello, Anna Maria, Monaco, Mario, Cavalcanti, Ernesta, Maiolino, Piera, Romagnoli, Giulia, Arra, Claudio, Botti, Gerardo, Gabriele, Lucia, Scala, Stefania

Source: Journal of experimental & clinical cancer research. 38(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130836226.0x000001&indx=1&recIds=ETOCvdc_100130836226.0x000001

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors

Authors: Ieranò, Caterina, Chakraborty, Arup, Nicolae, Alina, Bahr, Julian, Zhan, Zhirong, Pittaluga, Stefania, Bates, Susan, Robey, Robert

Source: Cell cycle. 12(17):2829-2838

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050673487.0x000001&indx=1&recIds=ETOCvdc_100050673487.0x000001

CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment.

Authors: Santagata, Sara, Ieranò, Caterina, Trotta, Anna Maria, Capiluongo, Anna, Auletta, Federica, Guardascione, Giuseppe, Scala, Stefania

Source: Frontiers in Oncology; 4/15/2021, Vol. 11, pN.PAG-N.PAG, 11p

Subject Terms: TUMOR microenvironment, CANCER cells, CXCR4 receptors, CHEMOKINE receptors, CELL migration

Novel Peptide-Based PET Probe for Non-invasive Imaging of C‑X‑C Chemokine Receptor Type 4 (CXCR4) in Tumors.

Authors: Trotta, Anna Maria, Aurilio, Michela, D'Alterio, Crescenzo, Ieranò, Caterina, Di Martino, Daria, Barbieri, Antonio, Luciano, Antonio, Gaballo, Paolo, Santagata, Sara, Portella, Luigi, Tomassi, Stefano, Marinelli, Luciana, Sementa, Deborah, Novellino, Ettore, Lastoria, Secondo, Scala, Stefania, Schottelius, Margret, Di Maro, Salvatore

Source: Journal of Medicinal Chemistry; 3/25/2021, Vol. 64 Issue 6, p3449-3461, 13p

Disulfide Bond Replacement with 1,4‐ and 1,5‐Disubstituted [1,2,3]‐Triazole on C‐X‐C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences.

Authors: Tomassi, Stefano¹, Trotta, Anna Maria², Ieranò, Caterina², Merlino, Francesco¹, Messere, Anna³, Rea, Giuseppina², Santoro, Federica¹, Brancaccio, Diego¹, Carotenuto, Alfonso¹, D'Amore, Vincenzo Maria¹, Di Leva, Francesco Saverio¹, Novellino, Ettore¹, Cosconati, Sandro³, Marinelli, Luciana¹, Scala, Stefania², s.scala@istitutotumori.na.it, Di Maro, Salvatore³, salvatore.dimaro@unicampania.it

Source: Chemistry - A European Journal; 8/6/2020, Vol. 26 Issue 44, p10113-10125, 13p

Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1.

Authors: D’Alterio, Crescenzo, Buoncervello, Maria, Ieranò, Caterina, Napolitano, Maria, Portella, Luigi, Rea, Giuseppina, Barbieri, Antonio, Luciano, Antonio, Scognamiglio, Giosuè, Tatangelo, Fabiana, Anniciello, Anna Maria, Monaco, Mario, Cavalcanti, Ernesta, Maiolino, Piera, Romagnoli, Giulia, Arra, Claudio, Botti, Gerardo, Gabriele, Lucia, Scala, Stefania

Source: Journal of Experimental & Clinical Cancer Research (17569966); 10/28/2019, Vol. 38 Issue 1, p1-13, 13p

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