Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells

Authors: Neves, Raquel Leão, Marem, Alyne, Carmona, Bruno, Arata, Júlia Galanakis, Cyrillo Ramos, Marcos Paulo, Justo, Giselle Zenker, Machado de Melo, Fabiana Henriques, Oliveira, Vitor, Icimoto, Marcelo Yudi

Source: In Biochimie September 2023 212:21-30

Thermodynamic analysis of Kex2 activity: The acylation and deacylation steps are potassium- and substrate-dependent

Authors: Antunes, Alyne Alexandrino, Jesus, Larissa de Oliveira Passos, Manfredi, Marcella Araújo, de Souza, Aline Aparecida, Machado, Maurício Ferreira Marcondes, e Silva, Pamela Moraes, Icimoto, Marcelo Yudi, Juliano, Maria Aparecida, Juliano, Luiz, Judice, Wagner Alves de Souza

Source: In Biophysical Chemistry April 2018 235:29-39

Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei

Authors: de Lima Stein, Mariana Leão, Icimoto, Marcelo Yudi, de Castro Levatti, Erica Valadares, Oliveira, Vitor, Straus, Anita Hilda, Schenkman, Sergio

Source: In Molecular & Biochemical Parasitology June 2017 214:36-46

In silico bioprospecting of receptors associated with the mechanism of action of Rondonin, an antifungal peptide from spider Acanthoscurria rondoniae haemolymph.

Authors: Muniz Seif, Elias Jorge^1,2 (AUTHOR), Icimoto, Marcelo Yudi³ (AUTHOR), Silva Júnior, Pedro Ismael^1,2,4 (AUTHOR) pisjr@butantan.gov.br

Source: In Silico Pharmacology. 6/9/2024, Vol. 12 Issue 1, p1-12. 12p.

Subject Terms: *PEPTIDES, *SPIDER venom, *SUCCINATE dehydrogenase, *HEMOLYMPH, *BIOPROSPECTING, *SMALL molecules

Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes.

Authors: El Chamy Maluf, Sarah¹ (AUTHOR), Icimoto, Marcelo Yudi¹ (AUTHOR), Melo, Pollyana Maria Saud¹ (AUTHOR), Budu, Alexandre¹ (AUTHOR), Coimbra, Rita² (AUTHOR), Gazarini, Marcos Leoni³ (AUTHOR) marcos.gazarini@unifesp.br, Carmona, Adriana Karaoglanovic¹ (AUTHOR) ak.carmona@unifesp.br

Source: Malaria Journal. 8/26/2020, Vol. 19 Issue 1, p1-10. 10p.

ACE2, ACE, DPPIV, PREP and CAT L enzymatic activities in COVID-19: imbalance of ACE2/ACE ratio and potential RAAS dysregulation in severe cases.

Authors: Neves, Raquel Leão, Branquinho, Jéssica, Arata, Júlia Galanakis, Bittencourt, Clarissa Azevedo, Gomes, Caio Perez, Riguetti, Michelle, da Mata, Gustavo Ferreira, Fernandes, Danilo Euclides, Icimoto, Marcelo Yudi, Kirsztajn, Gianna Mastroianni, Pesquero, João Bosco

Source: Inflammation Research; Aug2023, Vol. 72 Issue 8, p1719-1731, 13p

Subject Terms: ANGIOTENSIN converting enzyme, INFLAMMATORY mediators, COVID-19, COVID-19 pandemic, LOGISTIC regression analysis

The potential use of glycosyl-transferase inhibitors for targeted reduction of S. mutans biofilms in dental materials.

Authors: Scaffa, Polliana Mendes Candia, Kendall, Alexander, Icimoto, Marcelo Yudi, Fugolin, Ana Paula Piovezan, Logan, Matthew G., DeVito-Moraes, Andre G., Lewis, Steven H., Zhang, Hua, Wu, Hui, Pfeifer, Carmem S.

Source: Scientific Reports; 7/23/2023, Vol. 13 Issue 1, p1-12, 12p

Subject Terms: BIOFILMS, METHOXY compounds, STREPTOCOCCUS mutans, SMALL molecules, DENTAL materials, MATERIALS testing, POLYMERS

In silico bioprospecting of receptors for Doderlin: an antimicrobial peptide isolated from Lactobacillus acidophilus.

Authors: Muniz Seif, Elias Jorge^1,2 (AUTHOR), Icimoto, Marcelo Yudi³ (AUTHOR), da Silva Junior, Pedro Ismael^1,2 (AUTHOR) pisjr@butantan.gov.br

Source: In Silico Pharmacology. 4/25/2023, Vol. 11 Issue 1, p1-11. 11p.

Subject Terms: *ANTIMICROBIAL peptides, *LACTOBACILLUS acidophilus, *BIOPROSPECTING, *MOLECULAR docking, *PEPTIDES, *ANTIBIOTICS, *PEPTIDE antibiotics

Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production.

Authors: Borrego, Andrea, Colombo, Francesca, de Souza, Jean Gabriel, Jensen, José Ricardo, Dassano, Alice, Piazza, Rocco, Rodrigues dos Santos, Barbara Anaís, Ribeiro, Orlando Garcia, De Franco, Marcelo, Cabrera, Wafa Hanna Koury, Icimoto, Marcelo Yudi, Starobinas, Nancy, Magalhães, Geraldo, Monteleone, Leticia Figueiredo, Eto, Silas Fernandes, DeOcesano-Pereira, Carlos, Goldfeder, Mauricio Barbugiani, Pasqualoto, Kerly Fernanda Mesquita, Dragani, Tommaso A., Ibañez, Olga Célia Martinez

Source: Frontiers in Immunology; 6/21/2022, Vol. 13, p1-16, 16p

Subject Terms: LOCUS (Genetics), ADAPTOR proteins, INFLAMMASOMES, GENES, SINGLE nucleotide polymorphisms, INFLAMMATION

Disruption of Redox Homeostasis by Alterations in Nitric Oxide Synthase Activity and Tetrahydrobiopterin along with Melanoma Progression.

Authors: Soares, Jaqueline Pereira Moura, Gonçalves, Diego Assis, de Sousa, Ricardo Xisto, Mouro, Margareth Gori, Higa, Elisa M. S., Sperandio, Letícia Paulino, Vitoriano, Carolina Moraes, Rosa, Elisa Bachir Santa, Santos, Fernanda Oliveira dos, de Queiroz, Gustavo Nery, Yamaguchi, Roberta Sessa Stilhano, Pereira, Gustavo, Icimoto, Marcelo Yudi, Melo, Fabiana Henriques Machado de

Source: International Journal of Molecular Sciences; Jun2022, Vol. 23 Issue 11, p5979-5979, 20p

Subject Terms: NITRIC-oxide synthases, COFACTORS (Biochemistry), TETRAHYDROBIOPTERIN, MICROPHTHALMIA-associated transcription factor, WESTERN immunoblotting, HOMEOSTASIS, REACTIVE oxygen species

127 - The Role of Uncoupled Nitric Oxide Synthase in Melanoma Development

Authors: Gonçalves, Diego Assis, Sousa, Ricardo Xisto, Gonçalves, Jéssica Domingues, Silva, Douglas Baceti, Correa, Carla Sant Anna, Icimoto, Marcelo Yudi, Jasiulionis, Miriam Galvonas, Melo, Fabiana Machado

Source: In Free Radical Biology and Medicine November 2017 112 Supplement 1:95-95

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Increased Stability of Oligopeptidases Immobilized on Gold Nanoparticles.

Authors: Icimoto, Marcelo Yudi¹ (AUTHOR) adriannemmb@gmail.com, Brito, Adrianne Marlise Mendes^1,2 (AUTHOR) mcyrilloramos@gmail.com, Ramos, Marcos Paulo Cyrillo¹ (AUTHOR) vitor.oliveira@unifesp.br, Oliveira, Vitor¹ (AUTHOR), Nantes-Cardoso, Iseli Lourenço² (AUTHOR) icimoto@unifesp.br

Source: Catalysts (2073-4344). Jan2020, Vol. 10 Issue 1, p78. 1p.

Subject Terms: *GOLD nanoparticles, *SURFACE plasmon resonance, *STABILIZING agents, *ATOMIC force microscopy, *SODIUM borohydride

Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry.

Authors: Melo, Fabiana Henriques Machado de, Gonçalves, Diego Assis, Sousa, Ricardo Xisto de, Icimoto, Marcelo Yudi, Fernandes, Denise de Castro, Laurindo, Francisco R. M., Jasiulionis, Miriam Galvonas

Source: International Journal of Molecular Sciences; Sep2021, Vol. 22 Issue 17, p9556, 1p

Subject Terms: WESTERN immunoblotting, GLYCOCALYX, NITRIC-oxide synthases, STOICHIOMETRY, METASTASIS, MELANOMA, REACTIVE oxygen species

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Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development.

Authors: Gonçalves, Diego Assis^1,2 (AUTHOR), Xisto, Ricardo³ (AUTHOR), Gonçalves, Jéssica Domingues¹ (AUTHOR), da Silva, Douglas Baceti³ (AUTHOR), Moura Soares, Jaqueline Pereira³ (AUTHOR), Icimoto, Marcelo Yudi⁴ (AUTHOR), Sant'Anna, Carla³ (AUTHOR), Gimenez, Marcela³ (AUTHOR), de Angelis, Kátia³ (AUTHOR), Llesuy, Susana⁵ (AUTHOR), Fernandes, Denise C.⁶ (AUTHOR), Laurindo, Francisco⁶ (AUTHOR), Jasiulionis, Miriam Galvonas¹ (AUTHOR), Melo, Fabiana Henriques Machado de^1,3 (AUTHOR) fabiana.machado@fcmsantacasasp.edu.br

Source: International Journal of Biochemistry & Cell Biology. Oct2019, Vol. 115, pN.PAG-N.PAG. 1p.

Subject Terms: *SUPEROXIDES, *NITRIC-oxide synthases, *DACARBAZINE, *NITRIC oxide, *MELANOMA, *WESTERN immunoblotting, *ANIONS