Association of genetic ancestry with pre-eclampsia in multi-ethnic cohorts of pregnant women

Authors: Conti-Ramsden, Frances, de Marvao, Antonio, Gill, Carolyn, Chappell, Lucy C., Myers, Jenny, Vuckovic, Dragana, Dehghan, Abbas, Hysi, Pirro G.

Source: In Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health December 2024 38

Omega-3 Polyunsaturated Fatty Acids as a Protective Factor for Myopia

Authors: Xue, Can Can, Li, Hengtong, Dong, Xing-Xuan, Yu, Marco, Soh, Zhi Da, Chong, Crystal Chun Yuen, Jiang, Chen, Choquet, Helene, Zebardast, Nazlee, Zekavat, Seyedeh Maryam, Hysi, Pirro G., Saw, Seang Mei, Fan, Qiao, Tham, Yih-Chung, Pan, Chen-Wei, Cheng, Ching-Yu

Source: In American Journal of Ophthalmology December 2024 268:368-377

Electrical responses from human retinal cone pathways associate with a common genetic polymorphism implicated in myopia

Authors: Jiang, Xiaofan, Xu, Zihe, Soorma, Talha, Tariq, Ambreen, Bhatti, Taha, Baneke, Alexander J., Pontikos, Nikolas, Leo, Shaun M., Webster, Andrew R., Williams, Katie M., Hammond, Christopher J., Hysi, Pirro G., Mahroo, Omar A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 May . 119(21), 1-9.

Access URL: https://www.jstor.org/stable/27151955

Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disorders

Authors: Diaz-Torres, Santiago, He, Weixiong, Thorp, Jackson, Seddighi, Sahba, Mullany, Sean, Hammond, Christopher J., Hysi, Pirro G., Pasquale, Louis R., Khawaja, Anthony P., Hewitt, Alex W., Craig, Jamie E., Mackey, David A., Wiggs, Janey L., van Duijn, Cornelia, Lupton, Michelle K., Ong, Jue-Sheng, MacGregor, Stuart, Gharahkhani, Puya

Source: In eBioMedicine June 2023 92

A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Authors: Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, Ohno-Matsui, Kyoko

Source: In eBioMedicine May 2023 91

Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis

Authors: Stuart, Kelsey V., Madjedi, Kian, Luben, Robert N., Chua, Sharon Y.L., Warwick, Alasdair N., Chia, Mark, Pasquale, Louis R., Wiggs, Janey L., Kang, Jae H., Hysi, Pirro G., Tran, Jessica H., Foster, Paul J., Khawaja, Anthony P.

Source: In Ophthalmology June 2022 129(6):637-652

Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development

Authors: Simcoe, Mark J., Shah, Ameet, Fan, Baojian, Choquet, Hélène, Weisschuh, Nicole, Waseem, Naushin H., Jiang, Chen, Melles, Ronald B., Ritch, Robert, Mahroo, Omar A., Wissinger, Bernd, Jorgenson, Eric, Wiggs, Janey L., Garway-Heath, David F., Hysi, Pirro G., Hammond, Christopher J.

Source: In Ophthalmology June 2022 129(6):626-636

A genome-wide analysis of 340 318 participants identifies four novel loci associated with the age of first spectacle wear

Authors: Patasova, Karina, Khawaja, Anthony P, Wojciechowski, Robert, Mahroo, Omar A, Falchi, Mario, Rahi, Jugnoo S, Hammond, Chris J, Hysi, Pirro G

Source: Human molecular genetics. 31(17):3012-3019

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159662233.0x000001&indx=1&recIds=ETOCvdc_100159662233.0x000001

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank

Authors: Aung, Tin, Craig, Jamie E., Cheng, Ching-Yu, Cooke Bailey, Jessica N., Cree, Angela J., Foster, Paul J., Gharahkhani, Puya, Hammond, Christopher J., Hewitt, Alex W., Höhn, René, Hysi, Pirro G., Iglesias, Adriana I., Jonas, Jost B., Klaver, Caroline C.W., Khawaja, Anthony P., Khor, Chiea Chuen, Lotery, Andrew J., MacGregor, Stuart, Mackey, David A., Ong, Jue Sheng, Mitchell, Paul, Pasquale, Louis R., Pang, ChiPui, Pasutto, Francesca, Pfeiffer, Norbert, Segre, Ayellet V., van Duijn, Cornelia M., Viswanathan, Ananth C., Vitart, Veronique, Vithana, Eranga N., Wiggs, Janey L., Wojciechowski, Robert, Young, Terri L., Wong, Tien Yin, Yazar, Seyhan, Zebardast, Nazlee, Sekimitsu, Sayuri, Wang, Jiali, Elze, Tobias, Cole, Brian S., Lin, Michael M., Segrè, Ayellet V.

Source: In Ophthalmology September 2021 128(9):1300-1311

Evaluating vitamin C-related gene-environment and metabolite-environment interaction effects on intraocular pressure in the Canadian Longitudinal Study on Aging.

Authors: Lelievre, Rebecca, Rakesh, Mohan, Hysi, Pirro G., Little, Julian, Freeman, Ellen E., Roy-Gagnon, Marie-Hélène

Source: BMC Genomic Data; 1/29/2025, Vol. 26 Issue 1, p1-9, 9p

Subject Terms: GLAUCOMA, FALSE discovery rate, GENETIC variation, INTRAOCULAR pressure, ALCOHOL drinking

A genome-wide scan of non-coding RNAs and enhancers for refractive error and myopia.

Authors: Tedja, Milly S., Swierkowska-Janc, Joanna, Enthoven, Clair A., Meester-Smoor, Magda A., Hysi, Pirro G., Felix, Janine F., Cowan, Cameron S., Cherry, Timothy J., van der Spek, Peter J., Ghanbari, Mohsen, Erkeland, Stefan J., Barakat, Tahsin Stefan, Klaver, Caroline C. W., Verhoeven, Virginie J. M.

Source: Human Genetics; Jan2025, Vol. 144 Issue 1, p67-91, 25p

Subject Terms: GENETIC variation, LINCRNA, NON-coding RNA, LIFE sciences, BINDING sites, GENE enhancers

Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.

Authors: Diaz-Torres, Santiago, He, Weixiong, Yu, Regina, Han, Xikun, Hamel, Andrew R., Young, Terri L., Lotery, Andrew J., Jorgenson, Eric, Choquet, Hélène, Hauser, Michael, Cooke Bailey, Jessica N., Nakazawa, Toru, Shiga, Yukihiro, Segrè, Ayellet V., Khawaja, Anthony P., Hammond, Christopher J., Hysi, Pirro G., Pasquale, Louis R., Wu, Yeda, Kubo, Michiaki

Source: Nature Communications; 11/17/2024, Vol. 15 Issue 1, p1-9, 9p

Subject Terms: OPEN-angle glaucoma, INTRAOCULAR pressure, DRUG target, GLAUCOMA, NEUROPROTECTIVE agents

Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort: The UK Biobank

Authors: Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Blows, Peter, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Chua, Sharon Y.L., Crabb, David P., Cumberland, Philippa M., Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D., Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John E.J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Keane, Pearse A., Khaw, Sir Peng T., Khawaja, Anthony P., Lascaratos, Gerassimos, Lotery, Andrew J., Macgillivray, Tom, Mackie, Sarah, Martin, Keith, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O’Sullivan, Eoin, Owen, Chris G., Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., Yip, Jennifer, Zheng, Yalin, Chua, Sharon, Hysi, Pirro G., Georgoulas, Stelios, Currant, Hannah, Fitzgerald, Tomas W., Birney, Ewan, Ko, Fang, Yang, Qi, Reisman, Charles, Khaw, Peng T., Foster, Paul J., Patel, Praveen J.

Source: In Ophthalmology January 2020 127(1):62-71

GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations

Authors: Peng, Fuduan, Xiong, Ziyi, Zhu, Gu, Hysi, Pirro G., Eller, Ryan J., Wu, Sijie, Adhikari, Kaustubh, Chen, Yan, Li, Yi, Gonzalez-José, Rolando, Schüler-Faccini, Lavinia, Bortolini, Maria-Cátira, Acuña-Alonzo, Victor, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Bedoya, Gabriel, Rothhammer, Francisco, Uitterlinden, André G., Ikram, M. Arfan, Nijsten, Tamar, Ruiz-Linares, Andrés, Wang, Sijia, Walsh, Susan, Spector, Timothy D., Martin, Nicholas G., Kayser, Manfred, Liu, Fan

Source: Journal of investigative dermatology. 143(7):1317-1322.e11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193522561.0x000001&indx=1&recIds=ETOCvdc_100193522561.0x000001

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes

Authors: Laville, Vincent, Kang, Jae H., Cousins, Clara C., Iglesias, Adriana I., Nagy, Réka, Cooke Bailey, Jessica N., Igo, Robert P., Jr., Song, Yeunjoo E., Chasman, Daniel I., Christen, William G., Kraft, Peter, Rosner, Bernard A., Hu, Frank, Wilson, James F., Gharahkhani, Puya, Hewitt, Alex W., Mackey, David A., Hysi, Pirro G., Hammond, Christopher J., vanDuijn, Cornelia M., Haines, Jonathan L., Vitart, Veronique, Fingert, John H., Hauser, Michael A., Aschard, Hugues, Wiggs, Janey L., Khawaja, Anthony P., MacGregor, Stuart, Pasquale, Louis R.

Source: In American Journal of Ophthalmology October 2019 206:245-255

GWAS on retinal vasculometry phenotypes.

Authors: Jiang, Xiaofan^1,2 (AUTHOR), Hysi, Pirro G.^2,3,4 (AUTHOR), Khawaja, Anthony P.⁵ (AUTHOR), Mahroo, Omar A.^1,4 (AUTHOR), Xu, Zihe⁴ (AUTHOR), Hammond, Christopher J.^3,4,6 (AUTHOR), Foster, Paul J.⁵ (AUTHOR), Welikala, Roshan A.⁷ (AUTHOR), Barman, Sarah A.⁷ (AUTHOR), Whincup, Peter H.⁸ (AUTHOR), Rudnicka, Alicja R.⁸ (AUTHOR), Owen, Christopher G.⁸ (AUTHOR) cowen@sgul.ac.uk, Strachan, David P.⁸ (AUTHOR)

Source: PLoS Genetics. 2/9/2023, Vol. 18 Issue 2, p1-16. 16p.

Subject Terms: *RETINAL blood vessels, *RETINAL artery, *DIASTOLIC blood pressure, *GENOME-wide association studies, *BLOOD pressure, *CARDIOVASCULAR system, *PHENOTYPES

Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort

Authors: Khawaja, Anthony P., Chua, Sharon, Hysi, Pirro G., Georgoulas, Stelios, Currant, Hannah, Fitzgerald, Tomas W., Birney, Ewan, Ko, Fang, Yang, Qi, Reisman, Charles, Garway-Heath, David F., Hammond, Chris J., Khaw, Peng T., Foster, Paul J., Patel, Praveen J., Strouthidis, Nicholas

Source: Ophthalmology. 127(1):62-71

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097653281.0x000001&indx=1&recIds=ETOCvdc_100097653281.0x000001

Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV‐Infected Women

Authors: Tamraz, Bani, Huang, Yong, French, Audrey L., Kassaye, Seble, Anastos, Kathryn, Nowicki, Marek J., Gange, Stephen, Gustafson, Deborah R., Bacchetti, Peter, Greenblatt, Ruth M., Hysi, Pirro G., Aouizerat, Bradley E.

Source: Clinical pharmacology & therapeutics. 107(2):315-318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097877751.0x000001&indx=1&recIds=ETOCvdc_100097877751.0x000001

Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging.

Authors: Lelievre, Rebecca, Rakesh, Mohan, Hysi, Pirro G., Little, Julian, Freeman, Ellen E., Roy-Gagnon, Marie-Hélène

Source: Frontiers in Genetics; 2024, p1-11, 11p

Subject Terms: ESSENTIAL nutrients, GENOTYPE-environment interaction, GENOME-wide association studies, GENE mapping, ENVIRONMENTAL exposure, VITAMIN C

Ascorbic acid metabolites are involved in intraocular pressure control in the general population

Authors: Hysi, Pirro G., Khawaja, Anthony P., Menni, Cristina, Tamraz, Bani, Wareham, Nick, Khaw, Kay-Tee, Foster, Paul J., Benet, Leslie Z., Spector, Tim D., Hammond, Chris J.

Source: In Redox Biology January 2019 20:349-353