Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2cb00153ePreliminary accounts of the work has been reported: Tsuji, K.; Hymel, D.; Burke, T. R., Jr. Exploration of inhibitors targeting intramolecular protein–protein interaction.' 25th American Peptide Symposium, Whistler, Canada (June 17-22, 2017) poster P229 and Tsuji, K.; Hymel, D.; Ma, B.; Nussinov, R.; T. R. Burke, J. Unexpected findings in the development of bivalent polo-like kinase 1-binding ligands with potentially important implications. 26th American Peptide Symposium, Monterey, CA (June 22–27, 2019) poster YI-P261.

Authors: Tsuji, Kohei, Hymel, David, Ma, Buyong, Tamamura, Hirokazu, Nussinov, Ruth, Burke, Terrence R.

Source: RSC chemical biology. 3(9):1111-1120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159062490.0x000001&indx=1&recIds=ETOCvdc_100159062490.0x000001

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocyclesElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ob01120k

Authors: Hymel, David, Tsuji, Kohei, Grant, Robert A., Chingle, Ramesh M., Kunciw, Dominique L., Yaffe, Michael B., Burke, Terrence R.

Source: Organic & biomolecular chemistry. 19(36):7843-7854

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130208472.0x000001&indx=1&recIds=ETOCvdc_100130208472.0x000001

Proximity‐driven, Regioselective Chemical Modification of Peptides and Proteins

Authors: Hymel, David, Liu, Fa

Source: Asian journal of organic chemistry. 10(1):38-49

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114570045.0x000001&indx=1&recIds=ETOCvdc_100114570045.0x000001

Photochemically-enabled, post-translational production of C-terminal amides.

Authors: Hymel, David, Wojcik, Felix, Halskov, Kim S., Hogendorf, Wouter F. J., Wong, Sydnee C., Williams, Ben M., Mortensen, Asmus R., Cox, Nick, Misquith, Ayesha, Holländer, Nanna B., Matthiesen, Finn, Mehrotra, Suneet, Harris, Michael R.

Source: Nature Communications; 11/30/2024, Vol. 15 Issue 1, p1-8, 8p

Subject Terms: PEPTIDES, ACIDOLYSIS, DRUG target, AMIDATION, PROTEINS, DIELS-Alder reaction

Chemically Programmable and Switchable CAR‐T Therapy

Authors: Qi, Junpeng, Tsuji, Kohei, Hymel, David, Burke, Terrence R., Hudecek, Michael, Rader, Christoph, Peng, Haiyong

Source: Angewandte Chemie. 132(29):12276-12283

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116430071.0x000001&indx=1&recIds=ETOCvdc_100116430071.0x000001

A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/d0ay01223h

Authors: Tsuji, Kohei, Hymel, David, Burke, Terrence R.

Source: Analytical methods. 12(36):4418-4421

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110241474.0x000001&indx=1&recIds=ETOCvdc_100110241474.0x000001

Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides

Authors: Zhao, Xue Zhi, Hymel, David, Burke, Terrence R., Jr.

Source: In Bioorganic & Medicinal Chemistry 1 October 2017 25(19):5041-5049

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors

Authors: Hymel, David, Grant, Robert A., Tsuji, Kohei, Yaffe, Michael B., Burke, Terrence R.

Source: Bioorganic & medicinal chemistry letters. 28(19):3202-3205

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100072765799.0x000001&indx=1&recIds=ETOCvdc_100072765799.0x000001

Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain

Authors: Zhao, Xue Zhi, Hymel, David, Burke, Terrence R.

Source: Bioorganic & medicinal chemistry letters. 26(20):5009-5012

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069966669.0x000001&indx=1&recIds=ETOCvdc_100069966669.0x000001

Synthetic cell surface receptors for delivery of therapeutics and probes

Authors: Hymel, David, Peterson, Blake R.

Source: In Advanced Drug Delivery Reviews 15 June 2012 64(9):797-810

Relation of adipose tissue to metabolic flexibility

Authors: Sparks, Lauren M., Ukropcova, Barbara, Smith, Jana, Pasarica, Magdalena, Hymel, David, Xie, Hui, Bray, George A., Miles, John M., Smith, Steven R.

Source: In Diabetes Research and Clinical Practice 2009 83(1):32-43

Stable and Potent Selenomab-Drug Conjugates

Authors: Li, Xiuling, Nelson, Christopher G., Nair, Rajesh R., Hazlehurst, Lori, Moroni, Tina, Martinez-Acedo, Pablo, Nanna, Alex R., Hymel, David, Burke, Terrence R., Rader, Christoph

Source: Cell chemical biology. 24(4):433-442.e6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100043598442.0x000001&indx=1&recIds=ETOCvdc_100043598442.0x000001

Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist

Authors: Mehrotra, Suneet, Lam, Sebastian, Glenn, Elizabeth, Hymel, David, Sanford, Christina A., Liu, Qingyuan, Herich, John, Wulff, Birgitte S., Meek, Thomas H.

Source: ACS Bio & Med Chem Au; August 2022, Vol. 2 Issue: 4 p370-375, 6p

Further Exploration of Hydrazine-Mediated Bioconjugation Chemistries.

Authors: Mailig, Melrose, Hymel, David, Liu, Fa

Source: Organic Letters; 8/21/2020, Vol. 22 Issue 16, p6677-6681, 5p

Colorado community pharmacists' survey and their perspectives regarding marijuana.

Authors: Shea, Leticia A., Goldwire, Micheline A., Hymel, David, Bui, Doan

Source: SAGE Open Medicine; 7/29/2020, Vol. 8, p1-9, 9p

Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide.

Authors: Knewtson, Kelsey E., Perera, Chamani, Hymel, David, Zhe Gao, Lee, Molly M., Peterson, Blake R.

Source: ACS Omega; 7/31/2019, Vol. 4 Issue 7, p12955-12968, 14p

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Portable, DIY Chicken Coops.

Authors: Holliday, Heidi, Yapp, Claudia, Welter, Sonya, Haraldson, Dag, Haraldson, Dawn, Covington, Lori, Miller, Kirk, Ziegler, Mara, Hymel, David, Shafer, Bobbie, Barkley, Michael

Source: Mother Earth News. Apr/May2009, Issue 233, p20-23. 4p.

Subjects: SPOTTING (Cleaning), RECIPES (Cooking), DANDELIONS, RAISED bed gardening, GARDENING, COOKING

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