Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Authors: Saggau, Carina ^{1, 30}, Bacher, Petra ^{1, 2, 30}, Esser, Daniela ³, Rasa, Mahdi ^{1, 4}, Meise, Silja ¹, Mohr, Nicola ¹, Kohlstedt, Nora ¹, Hutloff, Andreas ^{1, 2}, Schacht, Sarah-Sophie ¹, Dargvainiene, Justina ³, Martini, Gabriela Rios ^{1, 2}, Stürner, Klarissa H. ^{3, 5}, Schröder, Ina ³, Markewitz, Robert ³, Hartl, Johannes ⁶, Hastermann, Maria ⁷, Duchow, Ankelien ⁷, Schindler, Patrick ⁷, Becker, Mareike ^{8, 9}, Bautista, Carolin ¹⁰, Gottfreund, Judith ¹¹, Walter, Jörn ¹¹, Polansky, Julia K. ^{12, 13}, Yang, Mingxing ¹², Naghavian, Reza ^{14, 15}, Wendorff, Mareike ^{2, 16}, Schuster, Ev-Marie ¹⁷, Dahl, Andreas ¹⁸, Petzold, Andreas ¹⁸, Reinhardt, Susanne ¹⁸, Franke, Andre ², Wieczorek, Marek ¹⁹, Henschel, Lea ¹⁹, Berger, Daniel ¹⁹, Heine, Guido ²⁰, Holtsche, Maike ²¹, Häußler, Vivien ²², Peters, Christian ¹, Schmidt, Enno ²¹, Fillatreau, Simon ^{23, 24, 25}, Busch, Dirk H. ²⁶, Wandinger, Klaus-Peter ³, Schober, Kilian ^{17, 27}, Martin, Roland ^{14, 15, 28, 29}, Paul, Friedemann ^{7, 30}, Leypoldt, Frank ^{3, 5, 30}, Scheffold, Alexander ^{1, 30, 31, ∗}

Source: In Immunity 8 October 2024 57(10):2416-2432

Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses

Authors: Wittner, Jens, Schulz, Sebastian R., Steinmetz, Tobit D., Berges, Johannes, Hauke, Manuela, Channell, William M., Cunningham, Adam F., Hauser, Anja E., Hutloff, Andreas, Mielenz, Dirk, Jäck, Hans-Martin, Schuh, Wolfgang

Source: In Mucosal Immunology April 2022 15(4):668-682

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Authors: Lino, Andreia C., Dang, Van Duc, Lampropoulou, Vicky, Welle, Anna, Joedicke, Jara, Pohar, Jelka, Simon, Quentin, Thalmensi, Jessie, Baures, Aurelia, Flühler, Vinciane, Sakwa, Imme, Stervbo, Ulrik, Ries, Stefanie, Jouneau, Luc, Boudinot, Pierre, Tsubata, Takeshi, Adachi, Takahiro, Hutloff, Andreas, Dörner, Thomas, Zimber-Strobl, Ursula, de Vos, Alex F., Dahlke, Katja, Loh, Gunnar, Korniotis, Sarantis, Goosmann, Christian, Weill, Jean-Claude, Reynaud, Claude-Agnès, Kaufmann, Stefan H.E., Walter, Jörn, Fillatreau, Simon

Source: In Immunity 17 July 2018 49(1):120-133

ICOS-Ligand, Expressed on Human Endothelial Cells, Costimulates Th1 and Th2 Cytokine Secretion by Memory CD4+ T Cells

Authors: Khayyamian, Saman, Hutloff, Andreas, Büchner, Kerstin, Gräfe, Michael, Henn, Volker, Kroczek, Richard A., Mages, Hans W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Apr . 99(9), 6198-6203.

Access URL: https://www.jstor.org/stable/3058649

Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen

Authors: Kretschmer, Birte, Weber, Jan, Hutloff, Andreas, Fleischer, Bernhard, Breloer, Minka, Osterloh, Anke

Source: In Immunobiology August 2015 220(8):964-975

Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs

Authors: Oefner, Carolin M., Winkler, André, Hess, Constanze, Lorenz, Alexandra K., Holecska, Vivien, Huxdorf, Melanie, Schommartz, Tim, Petzold, Dominique, Bitterling, Josephine, Schoen, Anna-Lena, Stoehr, Alexander D., Vu Van, Dana, Darcan-Nikolaisen, Yasemin, Blanchard, Véronique, Schmudde, Inken, Laumonnier, Yves, Ströver, Heike A., Hegazy, Ahmed N., Eiglmeier, Susanne, Schoen, Carolin T., Mertes, Maria M.M., Loddenkemper, Christoph, Löhning, Max, König, Peter, Petersen, Arnd, Luger, Elke O., Collin, Mattias, Köhl, Jörg, Hutloff, Andreas, Hamelmann, Eckard, Berger, Markus, Wardemann, Hedda, Ehlers, Marc

Source: In The Journal of Allergy and Clinical Immunology June 2012 129(6):1647-1655

Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8 + T Cells

Authors: Dorner, Brigitte G., Dorner, Martin B., Zhou, Xuefei, Opitz, Corinna, Mora, Ahmed, Güttler, Steffen, Hutloff, Andreas, Mages, Hans W., Ranke, Katja, Schaefer, Michael, Jack, Robert S., Henn, Volker, Kroczek, Richard A.

Source: In Immunity 2009 31(5):823-833

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

Authors: Linterman, Michelle A., Rigby, Robert J., Wong, Raphael, Silva, Diego, Withers, David, Anderson, Graham, Verma, Naresh K., Brink, Robert, Hutloff, Andreas, Goodnow, Chris C., Vinuesa, Carola G.

Source: In Immunity 2009 30(2):228-241

Emerging paradigms of T-cell co-stimulation

Authors: Kroczek, Richard A, Mages, Hans Werner, Hutloff, Andreas

Source: In Current Opinion in Immunology 2004 16(3):321-327

Inducible costimulator–positive T cells are required for allergen-induced local B-cell infiltration and antigen-specific IgE production in lung tissue

Authors: Beier, Katja C., Hutloff, Andreas, Löhning, Max, Kallinich, Tilmann, Kroczek, Richard A., Hamelmann, Eckard

Source: In The Journal of Allergy and Clinical Immunology 2004 114(4):775-782

Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis.

Authors: Bauer, Laura, Müller, Lisa Jasmin, Volkers, Sarah M., Heinrich, Frederik, Mashreghi, Mir-Farzin, Ruppert, Clemens, Sander, Leif E., Hutloff, Andreas

Source: American Journal of Respiratory & Critical Care Medicine; 12/15/2021, Vol. 204 Issue 12, p1403-1417, 15p

Subject Terms: SARCOIDOSIS, T cells, FOLLICULAR lymphoma, FLOW cytometry, COOPERATION

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.

Authors: Hutloff, Andreas, Dittrich, Anna M., Beier, Katja C.

Source: Nature; January 21 1999, Vol. 397 Issue 6716, p263-266, 4p

IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt⁺ Treg generation via enhanced IL‐6 induction.

Authors: Drube, Sebastian, Müller, Sylvia, Weber, Franziska, Wegner, Philine, Böttcher‐Loschinski, Romy, Gaestel, Matthias, Hutloff, Andreas, Kamradt, Thomas, Andreas, Nico

Source: Immunology; May2021, Vol. 163 Issue 1, p86-97, 12p

Subject Terms: MAST cells, MITOGEN-activated protein kinases, INTERLEUKIN-6, CYTOKINES, SUPPRESSOR cells

Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation.

Authors: Scholz, Josephine, Kuhrau, Julia, Heinrich, Frederik, Heinz, Gitta Anne, Hutloff, Andreas, Worm, Margitta, Heine, Guido

Source: Allergy; Apr2021, Vol. 76 Issue 4, p1109-1122, 14p

Subject Terms: T helper cells, B cell differentiation, B cells, T cells, VITAMIN A

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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.

Authors: Grimbacher, Bodo, Hutloff, Andreas, Schlesier, Michael, Glocker, Erik, Warnatz, Klaus, Drager, Ruth, Eibel, Hermann, Fischer, Beate, Schaffer, Alejandro A., Mages, Hans W., Kroczek, Richard A., Peter, Hans H.

Source: Nature Immunology. Mar2003, Vol. 4 Issue 3, p261. 8p.

Subject Terms: *IMMUNODEFICIENCY, *AGAMMAGLOBULINEMIA, *T cells

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IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection.

Authors: Sebina, Ismail^1,2, James, Kylie R.^1,2, Soon, Megan S. F.¹, Fogg, Lily G.¹, Best, Shannon E.¹, Labastida Rivera, Fabian de³, Montes de Oca, Marcela³, Amante, Fiona H.³, Thomas, Bryce S.¹, Beattie, Lynette³, Souza-Fonseca-Guimaraes, Fernando⁴, Smyth, Mark J.⁴, Hertzog, Paul J.⁵, Hill, Geoffrey R.⁶, Hutloff, Andreas⁷, Engwerda, Christian R.³, Haque, Ashraful¹, Ashraful.haque@qimrberghofer.edu.au

Source: PLoS Pathogens; 11/3/2016, Vol. 12 Issue 11, p1-26, 26p

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Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location.

Authors: Sarkander, Jana, Hojyo, Shintaro, Mursell, Mathias, Yamasaki, Yuzuru, Wu, Tsung-Yen, Tumes, Damon J., Miyauchi, Kosuke, Tran, Cam Loan, Zhu, Jinfang, Löhning, Max, Hutloff, Andreas, Mashreghi, Mir-Farzin, Kubo, Masato, Radbruch, Andreas, Tokoyoda, Koji

Source: Frontiers in Immunology; 1/15/2020, Vol. 10, p1-12, 12p

Subject Terms: T cells, CELL division, CYCLOPHOSPHAMIDE, MEMORY, BONE marrow