Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants

Authors: Silva, Dina Buitrago, Trinidad, Marena, Ljungdahl, Alicia, Revalde, Jezrael L., Berguig, Geoffrey Y., Wallace, William, Patrick, Cory S., Bomba, Lorenzo, Arkin, Michelle, Dong, Shan, Estrada, Karol, Hutchinson, Keino, LeBowitz, Jonathan H., Schlessinger, Avner, Johannesen, Katrine M., Møller, Rikke S., Giacomini, Kathleen M., Froelich, Steven, Sanders, Stephan J., Wuster, Arthur

Source: In The American Journal of Human Genetics 6 June 2024 111(6):1222-1238

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency

Authors: Koleske, Megan L., McInnes, Gregory, Brown, Julia E. H., Thomas, Neil, Hutchinson, Keino, Chin, Marcus Y., Koehl, Antoine, Arkin, Michelle R., Schlessinger, Avner, Gallagher, Renata C., Song, Yun S., Altman, Russ B., Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Nov . 119(46), 1-11.

Access URL: https://www.jstor.org/stable/27209367

Targeting SLC transporters: small molecules as modulators and therapeutic opportunities

Authors: Schlessinger, Avner, Zatorski, Nicole, Hutchinson, Keino, Colas, Claire

Source: Trends in biochemical sciences. 48(9):801-814

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195189433.0x000001&indx=1&recIds=ETOCvdc_100195189433.0x000001

Describing inhibitor specificity for the amino acid transporter LAT1 from metainference simulations

Authors: Hutchinson, Keino, Silva, Dina Buitrago, Bohlke, Joshua, Clausen, Chase, Thomas, Allen A., Bonomi, Massimiliano, Schlessinger, Avner

Source: In Biophysical Journal 6 December 2022 121(23):4476-4491

The Effects of Prodrug Size and a Carbonyl Linker on l‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake

Authors: Venteicher, Brooklynn, Merklin, Kasey, Ngo, Huy X., Chien, Huan‐Chieh, Hutchinson, Keino, Campbell, Jerome, Way, Hannah, Griffith, Joseph, Alvarado, Cesar, Chandra, Surabhi, Hill, Evan, Schlessinger, Avner, Thomas, Allen A.

Source: ChemMedChem. 16(5):869-880

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115859870.0x000001&indx=1&recIds=ETOCvdc_100115859870.0x000001

Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters

Authors: Ndaru, Elias, Zielewicz, Laura, Shi, Yueyue, Hutchinson, Keino, Garibsingh, Rachel‐Ann A., Schlessinger, Avner, Grewer, Christof

Source: Journal of physical organic chemistry. 35(11)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165343554.0x000001&indx=1&recIds=ETOCvdc_100165343554.0x000001

Comprehensive Characterization of LAT1 Cholesterol-Binding Sites.

Authors: Hutchinson, Keino, Schlessinger, Avner

Source: Journal of Chemical Theory & Computation; 4/23/2024, Vol. 20 Issue 8, p3349-3358, 10p

Ligand discovery for LAT1 with molecular dynamics simulation and virtual screening

Authors: Hutchinson, Keino K., Buitrago Silva, Dina, Ngo, Huy, Schlessinger, Avner, Giacomini, Kathleen, Thomas, Allen

Source: Biophysical journal. 121(S1):8a-8a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177559052.0x000001&indx=1&recIds=ETOCvdc_100177559052.0x000001

Conserved allosteric inhibition mechanism in SLC1 transporters.

Authors: Yang Dong, Jiali Wang, Garibsingh, Rachel-Ann, Hutchinson, Keino, Yueyue Shi, Eisenberg, Gilad, Xiaozhen Yu, Schlessinger, Avner, Grewer, Christof

Source: eLife; 3/15/2023, p1-26, 26p

Substrate binding and inhibition of the anion exchanger 1 transporter

Authors: Capper, Michael J., Yang, Shifan, Stone, Alexander C., Vatansever, Sezen, Zilberg, Gregory, Mathiharan, Yamuna Kalyani, Habib, Raul, Hutchinson, Keino, Zhao, Yihan, Schlessinger, Avner, Mezei, Mihaly, Osman, Roman, Zhang, Bin, Wacker, Daniel

Source: Nature Structural and Molecular Biology; 20230101, Issue: Preprints p1-10, 10p

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