Serological evidence of SARS‐CoV‐2 and co‐infections in stray cats in Spain

Authors: Villanueva‐Saz, Sergio, Giner, Jacobo, Tobajas, Ana Pilar, Pérez, María Dolores, González‐Ramírez, Andrés Manuel, Macías‐León, Javier, González, Ana, Verde, Maite, Yzuel, Andrés, Hurtado‐Guerrero, Ramón, Pardo, Julián, Santiago, Llipsy, Paño‐Pardo, José Ramón, Ruíz, Héctor, Lacasta, Delia María, Sánchez, Lourdes, Marteles, Diana, Gracia, Ana Pilar, Fernández, Antonio

Source: Transboundary and emerging diseases. 69(3):1056-1064

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149279552.0x000001&indx=1&recIds=ETOCvdc_100149279552.0x000001

Loop engineering of enzymes to control their immobilization and ultimately fabricate more efficient heterogeneous biocatalysts.

Authors: Zeballos, Nicoll, Ginés‐Alcober, Irene, Macías‐León, Javier, Andrés‐Sanz, Daniel, González‐Ramírez, Andrés Manuel, Sánchez‐Costa, Mercedes, Merino, Pedro, Hurtado‐Guerrero, Ramón, López‐Gallego, Fernando

Source: Protein Science: A Publication of the Protein Society; Feb2025, Vol. 34 Issue 2, p1-12, 12p

O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond

Authors: Berardinelli, Steven J., Eletsky, Alexander, Valero-González, Jessika, Ito, Atsuko, Manjunath, Rajashri, Hurtado-Guerrero, Ramon, Prestegard, James H., Woods, Robert J., Haltiwanger, Robert S.

Source: In Journal of Biological Chemistry June 2022 298(6)

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Authors: Latorre-Muro, Pedro, Baeza, Josue, Hurtado-Guerrero, Ramon, Hicks, Thomas, Delso, Ignacio, Hernández-Ruiz, Cristina, Velázquez-Campoy, Adrian, Lawton, Alexis J., Angulo, Jesús, Denu, John M., Carrodeguas, José A.

Source: In Journal of Biological Chemistry January-June 2021 296

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition

Authors: Rubio‐Ruiz, Belén, Serrán‐Aguilera, Lucía, Hurtado‐Guerrero, Ramón, Conejo‐García, Ana

Source: Medicinal research reviews. 41(2):902-927

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117652384.0x000001&indx=1&recIds=ETOCvdc_100117652384.0x000001

Development of a FUT8 Inhibitor with Cellular Inhibitory Properties.

Authors: Manabe, Yoshiyuki^1,2, manabey12@chem.sci.osaka-u.ac.jp, Takebe, Tomoyuki¹, Kasahara, Satomi¹, Hizume, Koki¹, Kabayama, Kazuya^1,2,3, Kamada, Yoshihiro⁴, Asakura, Akiko⁵, Shinzaki, Shinichiro^5,6, Takamatsu, Shinji⁷, Miyoshi, Eiji⁷, García‐García, Ana⁸, Vakhrushev, Sergey Y.⁹, Hurtado‐Guerrero, Ramón^8,9,10, Fukase, Koichi^1,2,11, koichi@chem.sci.osaka-u.ac.jp

Source: Angewandte Chemie International Edition; 12/20/2024, Vol. 63 Issue 52, p1-8, 8p

Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism

Authors: Serrán- Aguilera, Lucía, Mariotto, Elena, Rubbini, Gianluca, Castro Navas, Francisco Fermín, Marco, Carmen, Carrasco-Jiménez, María Paz, Ballarotto, Marco, Macchiarulo, Antonio, Hurtado-Guerrero, Ramón, Viola, Giampietro, Lopez-Cara, Luisa Carlota

Source: In European Journal of Medicinal Chemistry 1 December 2020 207

Polypeptide GalNAc-Ts: from redundancy to specificity

Authors: de las Rivas, Matilde, Lira-Navarrete, Erandi, Gerken, Thomas A., Hurtado-Guerrero, Ramon

Source: In Current Opinion in Structural Biology June 2019 56:87-96

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibodyElectronic supplementary information (ESI) available. See DOI: 10.1039/d0cc06349e

Authors: Macías-LeónI. A. B., A. A., I. C., V. M. and R. F. synthesized, purified and characterized the glycopeptides. F. C. performed and analyzed the MD simulations. J. M.-L., I. S. A., G. J. L. B. and R. H.-G. purified antibody scFv-5E5. J. M.-L. and R. H.-G. crystallized the complex and refined the crystal structure. R. H.-G. and A. G.-G. performed the ITC and microscale thermophoresis experiments. O. B. and H. J. J. accomplished the microarray assays. H. C., F. M., J. L. A., E. J.-M. and F. C. performed the conformational analysis of glycopeptide MUC1-Tn16 by combining NMR and MD simulations. H. C. and F. M. performed the STD-NMR experiments. F. C. and R. H.-G. wrote the article with the other authors' contributions., Javier, Bermejo, Iris A., Asín, Alicia, García-García, Ana, Compañón, Ismael, Jiménez-Moreno, Ester, Coelho, Helena, Mangini, Vincenzo, Albuquerque, Inês S., Marcelo, Filipa, Asensio, Juan L., Bernardes, Gonçalo J. L., Joshi, Hiren J., Fiammengo, Roberto, Blixt, Ola, Hurtado-Guerrero, Ramón, Corzana, Francisco

Source: Chemical communications. 56(96):15137-15140

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111603595.0x000001&indx=1&recIds=ETOCvdc_100111603595.0x000001

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragmentElectronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06334j

Authors: Bermejo, Iris A., Navo, Claudio D., Castro-López, Jorge, Guerreiro, Ana, Jiménez-Moreno, Ester, Sánchez Fernández, Elena M., García-Martín, Fayna, Hinou, Hiroshi, Nishimura, Shin-Ichiro, García Fernández, José M., Mellet, Carmen Ortiz, Avenoza, Alberto, Busto, Jesús H., Bernardes, Gonçalo J. L., Hurtado-Guerrero, Ramón, Peregrina, Jesús M., Corzana, Francisco

Source: Chemical science. 11(15):3996-4006

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110068595.0x000001&indx=1&recIds=ETOCvdc_100110068595.0x000001

Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes.

Authors: Corzana, Francisco¹, francisco.corzana@unirioja.es, Asín, Alicia¹, Eguskiza, Ander², De Tomi, Elisa³, Martín‐Carnicero, Alfonso⁴, Martínez‐Moral, María P.^5,6, Mangini, Vincenzo⁷, Papi, Francesco⁸, Bretón, Carmen¹, Oroz, Paula¹, Lagartera, Laura⁹, Jiménez‐Moreno, Ester¹, Avenoza, Alberto¹, Busto, Jesús H.¹, Nativi, Cristina⁸, Asensio, Juan L.¹⁰, Hurtado‐Guerrero, Ramón^11,12,13, Peregrina, Jesús M.¹, Malerba, Giovanni³, giovanni.malerba@univr.it, Martínez, Alfredo⁵, amartinezr@riojasalud.es

Source: Angewandte Chemie International Edition; 9/9/2024, Vol. 63 Issue 37, p1-12, 12p

Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors.

Authors: Manabe, Yoshiyuki, Hizume, Koki, Takakura, Yohei, Takamatsu, Shinji, Miyoshi, Eiji, Kamada, Yoshihiro, Hurtado-Guerrero, Ramón, Fukase, Koichi

Source: Synlett; Jul2024, Vol. 35 Issue 11, p1273-1278, 6p

Subject Terms: ANTIBODY-dependent cell cytotoxicity, VASCULAR endothelial growth factors, POST-translational modification

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions

Authors: Latorre-Muro, Pedro, Baeza, Josue, Armstrong, Eric A., Hurtado-Guerrero, Ramón, Corzana, Francisco, Wu, Lindsay E., Sinclair, David A., López-Buesa, Pascual, Carrodeguas, José A., Denu, John M.

Source: In Molecular Cell 6 September 2018 71(5):718-732

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

Authors: Wang, Shengjun, Mao, Yang, Narimatsu, Yoshiki, Ye, Zilu, Tian, Weihua, Goth, Christoffer K., Lira-Navarrete, Erandi, Pedersen, Nis B., Benito-Vicente, Asier, Martin, Cesar, Uribe, Kepa B., Hurtado-Guerrero, Ramon, Christoffersen, Christina, Seidah, Nabil G. ^**, Nielsen, Rikke, Christensen, Erik I., Hansen, Lars, Bennett, Eric P., Vakhrushev, Sergey Y., Schjoldager, Katrine T., Clausen, Henrik

Source: In Journal of Biological Chemistry 11 May 2018 293(19):7408-7422

Innenrücktitelbild: The Essential Role of Water Molecules in the Reaction Mechanism of Protein O‐Fucosyltransferase 2 (Angew. Chem. 48/2022)

Authors: Sanz‐Martínez, Ignacio, García‐García, Ana, Tejero, Tomás, Hurtado‐Guerrero, Ramón, Merino, Pedro

Source: Angewandte Chemie. 134(48)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165301779.0x000001&indx=1&recIds=ETOCvdc_100165301779.0x000001

The Essential Role of Water Molecules in the Reaction Mechanism of Protein O‐Fucosyltransferase 2

Authors: Sanz‐Martínez, Ignacio, García‐García, Ana, Tejero, Tomás, Hurtado‐Guerrero, Ramón, Merino, Pedro

Source: Angewandte Chemie. 134(48)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165301731.0x000001&indx=1&recIds=ETOCvdc_100165301731.0x000001

Inside Back Cover: The Essential Role of Water Molecules in the Reaction Mechanism of Protein O‐Fucosyltransferase 2 (Angew. Chem. Int. Ed. 48/2022)

Authors: Sanz‐Martínez, Ignacio, García‐García, Ana, Tejero, Tomás, Hurtado‐Guerrero, Ramón, Merino, Pedro

Source: Angewandte Chemie international edition. 61(48)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165302385.0x000001&indx=1&recIds=ETOCvdc_100165302385.0x000001

The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein

Alternate Title: Luteolin inhibits ppGalNAc-Ts (English)

Authors: Liu, Feng, Xu, Kai, Xu, Zhijue, de las Rivas, Matilde, Wang, Congrong, Li, Xing, Lu, Jishun, Zhou, Yueyang, Delso, Ignacio ^**, Merino, Pedro, Hurtado-Guerrero, Ramon, Zhang, Yan, Wu, Fang

Source: In Journal of Biological Chemistry 29 December 2017 292(52):21304-21319

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity

Authors: El Qaidi, Samir, Chen, Kangming, Halim, Adnan, Siukstaite, Lina, Rueter, Christian, Hurtado-Guerrero, Ramon ^**, Clausen, Henrik, Hardwidge, Philip R.

Source: In Journal of Biological Chemistry 7 July 2017 292(27):11423-11430

Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2.

Authors: Manabe, Yoshiyuki, Gárate-Reyes, Brandon, Ito, Keita, Hurtado-Guerrero, Ramón, Kabayama, Kazuya, Fukase, Koichi

Source: Chemical Communications; 4/14/2024, Vol. 60 Issue 29, p3946-3949, 4p

Subject Terms: SARS-CoV-2, CORONAVIRUSES, VACCINES, COVID-19, SYNDROMES