Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS

Authors: Ramona Gerhards, Lena Kristina Pfeffer, Jessica Lorenz, Laura Starost, Luise Nowack, Franziska S. Thaler, Miriam Schlüter, Heike Rübsamen, Caterina Macrini, Stephan Winklmeier, Simone Mader, Mattias Bronge, Hans Grönlund, Regina Feederle, Hung-En Hsia, Stefan F. Lichtenthaler, Juliane Merl-Pham, Stefanie M. Hauck, Tanja Kuhlmann, Isabel J. Bauer, Eduardo Beltran, Lisa Ann Gerdes, Aleksandra Mezydlo, Amit Bar-Or, Brenda Banwell, Mohsen Khademi, Tomas Olsson, Reinhard Hohlfeld, Hans Lassmann, Tania Kümpfel, Naoto Kawakami, Edgar Meinl

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)

Subject Terms: Autoantigen, Multiple sclerosis, Neuroinflammation, Autoimmunity, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/48e9a477e7444c7f8deb69565051b888

The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis.

Authors: Jocher, Georg, Ozcelik, Gozde, Müller, Stephan A., Hung-En Hsia, Osua, Miranda Lastra, Hofmann, Laura I., Aßfalg, Marlene, Dinkel, Lina, Xiao Feng, Schlepckow, Kai, Willem, Michael, Haass, Christian, Tahirovic, Sabina, Blobel, Carl P., Lichtenthaler, Stefan F.

Source: Life Science Alliance; May2025, Vol. 8 Issue 5, p1-16, 16p

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

Authors: Hung-En Hsia¹, Kumar, Rohit¹, Luca, Rossella^2,3,4, Michiko Takeda¹, Courchet, Julien^5,6, Nakashima, Jonathan⁷, Shumin Wu⁷, Goebbels, Sandra⁸, Wenlin An^9,10, Eickholt, Britta J.^9,10, Polleux, Franck^5,6, Rotin, Daniela^11,12, Hong Wu⁷, Rossner, Moritz J.^8,13, Bagni, Claudia^2,3,4,14, Jeong-Seop Rhee¹, Brose, Nils¹, Hiroshi Kawabe¹ kawabe@em.mpg.de

Source: Proceedings of the National Academy of Sciences of the United States of America. 9/9/2014, Vol. 111 Issue 36, p13205-13210. 6p.

Subject Terms: *UBIQUITINATION, *UBIQUITIN, *PTEN protein, *LIGASES, *NEURON development, *CENTRAL nervous system, *AXONS

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The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.

Authors: Chek Ziu Koo^1,2, Harrison, Neale¹, Noy, Peter J.¹, Szyroka, Justyna¹, Matthews, Alexandra L.¹, Hung-En Hsia³, Müller, Stephan A.³, Tüshaus, Johanna³, Goulding, Joelle^2,4, Willis, Katie¹, Apicella, Clara¹, Cragoe, Bethany¹, Davis, Edward¹, Keles, Murat¹, Malinova, Antonia¹, McFarlane, Thomas A.¹, Morrison, Philip R.¹, Nguyen, Hanh T. H.¹, Sykes, Michael C.¹, Ahmed, Haroon¹

Source: Journal of Biological Chemistry. 9/4/2020, Vol. 295 Issue 36, p12822-12839. 18p.

Subject Terms: *MEMBRANE proteins, *CHIMERIC proteins, *MONOCLONAL antibodies, *EMBRYOLOGY, *CELL lines