Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

Authors: Walters, Jewell N., Schouest, Blake, Patel, Ami, Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Maricic, Igor, Gary, Ebony N., Purwar, Mansi, Andrade, Viviane M., Doan, Arthur, Elwood, Dustin, Eblimit, Zeena, Nguyen, Brian, Frase, Drew, Zaidi, Faraz I., Kulkarni, Abhijeet, Generotti, Alison, Joseph Kim, J, Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.

Source: Vaccine. 40(21):2960-2969

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170833927.0x000001&indx=1&recIds=ETOCvdc_100170833927.0x000001

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

Authors: Tebas, Pablo, Yang, ShuPing, Boyer, Jean D., Reuschel, Emma L., Patel, Ami, Christensen-Quick, Aaron, Andrade, Viviane M., Morrow, Matthew P., Kraynyak, Kimberly, Agnes, Joseph, Purwar, Mansi, Sylvester, Albert, Pawlicki, Jan, Gillespie, Elisabeth, Maricic, Igor, Zaidi, Faraz I., Kim, Kevin Y., Dia, Yaya, Frase, Drew, Pezzoli, Patrick, Schultheis, Katherine, Smith, Trevor R.F., Ramos, Stephanie J., McMullan, Trevor, Buttigieg, Karen, Carroll, Miles W., Ervin, John, Diehl, Malissa C., Blackwood, Elliott, Mammen, Mammen P., Lee, Jessica, Dallas, Michael J., Brown, Ami Shah, Shea, Jacqueline E., Kim, J.Joseph, Weiner, David B., Broderick, Kate E., Humeau, Laurent M.

Source: In EClinicalMedicine January 2021 31

One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model

Authors: Gooch, Karen E., Smith, Trevor R.F., Salguero, Francisco J., Fotheringham, Susan A., Watson, Robert J., Dennis, Mike J., Handley, Alastair, Humphries, Holly E., Longet, Stephanie, Tipton, Tom, Sarfas, Charlotte, Sibley, Laura, Slack, Gillian S., Rayner, Emma, Ryan, Kathryn A., Schultheis, Katherine, Ramos, Stephanie J., White, Andrew, Charlton, Sue, Sharpe, Sally A., Gleeson, Fergus, Humeau, Laurent M., Hall, Yper, Broderick, Kate E., Carroll, Miles W.

Source: Vaccine. 39(34):4885-4894

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100162792370.0x000001&indx=1&recIds=ETOCvdc_100162792370.0x000001

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

Authors: Schultheis, Katherine, Pugh, Holly M, Oh, Janet, Nguyen, Jacklyn, Yung, Bryan, Reed, Charles, Cooch, Neil, Chen, Jing, Yan, Jian, Muthumani, Kar, Humeau, Laurent M., Weiner, David B., Broderick, Kate E., Smith, Trevor R. F.

Source: Human vaccines & immunotherapeutics. 16(9):2165-2175

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127330679.0x000001&indx=1&recIds=ETOCvdc_100127330679.0x000001

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques

Authors: Jiang, Jingjing, Banglore, Preeti, Cashman, Kathleen A., Schmaljohn, Connie S., Schultheis, Katherine, Pugh, Holly, Nguyen, Jacklyn, Humeau, Laurent M., Broderick, Kate E., Ramos, Stephanie J.

Source: Human vaccines & immunotherapeutics. 15(9):2066-2074

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110843564.0x000001&indx=1&recIds=ETOCvdc_100110843564.0x000001

Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses

Authors: Jiang, Jingjing, Ramos, Stephanie J., Bangalore, Preeti, Fisher, Paul, Germar, Kristine, Lee, Brian K., Williamson, Dan, Kemme, Andrea, Schade, Eric, McCoy, Jay, Muthumani, Kar, Weiner, David B., Humeau, Laurent M., Broderick, Kate E.

Source: Vaccine. 37(29):3832-3839

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097736279.0x000001&indx=1&recIds=ETOCvdc_100097736279.0x000001

Enhanced Delivery of DNA or RNA Vaccines by Electroporation

Authors: Broderick, Kate E., Humeau, Laurent M.

Source: Methods in molecular biology. 1499:193-202

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609432820&indx=1&recIds=ETOCRN609432820

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)

Authors: Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.

Source: Advanced science. 7(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109020925.0x000001&indx=1&recIds=ETOCvdc_100109020925.0x000001

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

Authors: Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.

Source: Advanced science. 7(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109020251.0x000001&indx=1&recIds=ETOCvdc_100109020251.0x000001

Immunogenicity of a DNA vaccine candidate for COVID-19

Authors: Smith, Trevor R. F., Patel, Ami, Ramos, Stephanie, Elwood, Dustin, Zhu, Xizhou, Yan, Jian, Gary, Ebony N., Walker, Susanne N., Schultheis, Katherine, Purwar, Mansi, Xu, Ziyang, Walters, Jewell, Bhojnagarwala, Pratik, Yang, Maria, Chokkalingam, Neethu, Pezzoli, Patrick, Parzych, Elizabeth, Reuschel, Emma L., Doan, Arthur, Tursi, Nicholas, Vasquez, Miguel, Choi, Jihae, Tello-Ruiz, Edgar, Maricic, Igor, Bah, Mamadou A., Wu, Yuanhan, Amante, Dinah, Park, Daniel H., Dia, Yaya, Ali, Ali Raza, Zaidi, Faraz I., Generotti, Alison, Kim, Kevin Y., Herring, Timothy A., Reeder, Sophia, Andrade, Viviane M., Buttigieg, Karen, Zhao, Gan, Wu, Jiun-Ming, Li, Dan, Bao, Linlin, Liu, Jiangning, Deng, Wei, Qin, Chuan, Brown, Ami Shah, Khoshnejad, Makan, Wang, Nianshuang, Chu, Jacqueline, Wrapp, Daniel, McLellan, Jason S., Muthumani, Kar, Wang, Bin, Carroll, Miles W., Kim, J. Joseph, Boyer, Jean, Kulp, Daniel W., Humeau, Laurent M. P. F., Weiner, David B., Broderick, Kate E.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174601139.0x000001&indx=1&recIds=ETOCvdc_100174601139.0x000001

Electroporation-enhanced delivery of nucleic acid vaccines

Authors: Broderick, Kate E, Humeau, Laurent M

Source: Expert review of vaccines. 14(2):195-204

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103608191.0x000001&indx=1&recIds=ETOCvdc_100103608191.0x000001

Gene Transfer in Humans Using a Conditionally Replicating Lentiviral Vector

Authors: Levine, Bruce L., Humeau, Laurent M., Boyer, Jean, MacGregor, Rob-Roy, Rebello, Tessio, Lu, Xiaobin, Binder, Gwendolyn K., Slepushkin, Vladimir, Lemiale, Franck, Mascola, John R., Bushman, Frederic D., Dropulic, Boro, June, Carl H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2006 Nov . 103(46), 17372-17377.

Access URL: https://www.jstor.org/stable/30052439

COMPOSITIONS AND METHODS FOR GENERATION OF PLURIPOTENT STEM CELLS

LENTIVIRUS-BASED IMMUNOGENIC VECTORS

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

Authors: Humeau, Laurent M ^*, Binder, Gwendolyn K ^*, Lu, Xiaobin, Slepushkin, Vladimir, Merling, Randall, Echeagaray, Patricia, Pereira, Mario, Slepushkina, Tatiana, Barnett, Scott, Dropulic, Lesia K, Carroll, Richard, Levine, Bruce L, June, Carl H, Dropulic, Boro

Source: In Molecular Therapy June 2004 9(6):902-913

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210. Complete Control of Tumor Growth In Vivo By a Synthetic Consensus Multi-Antigen DNA Immune Therapy for Prostate Cancer

Authors: Ferraro, Bernadette, Walters, Jewell N., Reuschel, Emma L., Balakrishnan, Amrthia, Morrow, Matthew P., Yan, Jian, Khan, Amir S., Sardesai, Niranjan Y., Humeau, Laurent M., Weiner, David B.

Source: In Molecular Therapy May 2015 23 Supplement 1:S83-S83

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