Fed-BioMed: Open, Transparent and Trusted Federated Learning for Real-world Healthcare Applications

Authors: Cremonesi, Francesco, Vesin, Marc, Cansiz, Sergen, Bouillard, Yannick, Balelli, Irene, Innocenti, Lucia, Silva, Santiago, Ayed, Samy-Safwan, Taiello, Riccardo, Kameni, Laetita, Vidal, Richard, Orlhac, Fanny, Nioche, Christophe, Lapel, Nathan, Houis, Bastien, Modzelewski, Romain, Humbert, Olivier, Önen, Melek, Lorenzi, Marco

Source: Federated Learning Systems, 2nd ed., Springer, 2025. Part of Studies in Computational Intelligence, vol. 832. ISBN 978-3-031-78840-6

Subject Terms: Computer Science - Machine Learning, Computer Science - Distributed, Parallel, and Cluster Computing

Access URL: http://arxiv.org/abs/2304.12012

Are labels informative in semi-supervised learning? -- Estimating and leveraging the missing-data mechanism

Authors: Sportisse, Aude, Schmutz, Hugo, Humbert, Olivier, Bouveyron, Charles, Mattei, Pierre-Alexandre

Subject Terms: Statistics - Machine Learning

Access URL: http://arxiv.org/abs/2302.07540

Protection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques

Authors: Petty, Nicholas E. ^{1, 2}, Radtke, Stefan ^{1, 3}, Kanestrom, Greta ¹, Fields, Emily ¹, Humbert, Olivier ¹, Fiorenza, Salvatore ¹, Llewellyn, Mallory J. ¹, Laszlo, George S. ¹, Thomas, Justin ^{1, 2}, Burger, Zach ¹, Swing, Kyle ¹, Zhu, Haiying ⁴, Jerome, Keith R. ^{4, 5}, Turtle, Cameron J. ¹, Walter, Roland B. ^{1, 3, 4}, Kiem, Hans-Peter ^{1, 3, 4, ∗}

Source: In Blood Advances January 2025

Privacy Preserving Image Registration

Authors: Taiello, Riccardo, Önen, Melek, Capano, Francesco, Humbert, Olivier, Lorenzi, Marco

Source: Medical Image Analysis Medical Image Analysis, Volume 94, May 2024, 103129

Subject Terms: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Cryptography and Security, Electrical Engineering and Systems Science - Image and Video Processing

Access URL: http://arxiv.org/abs/2205.10120

Don't fear the unlabelled: safe semi-supervised learning via simple debiasing

Authors: Schmutz, Hugo, Humbert, Olivier, Mattei, Pierre-Alexandre

Subject Terms: Statistics - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Statistics - Computation, Statistics - Methodology

Access URL: http://arxiv.org/abs/2203.07512

Privacy preserving image registration

Authors: Taiello, Riccardo, Önen, Melek, Capano, Francesco, Humbert, Olivier, Lorenzi, Marco

Source: In Medical Image Analysis May 2024 94

Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

Authors: Petty, Nicholas E., Radtke, Stefan, Fields, Emily, Humbert, Olivier, Llewellyn, Mallory J., Laszlo, George S., Zhu, Haiying, Jerome, Keith R., Walter, Roland B., Kiem, Hans-Peter

Source: In Molecular Therapy - Methods & Clinical Development 14 December 2023 31

Plasmatic Inactive IL-18 Predicts a Worse Overall Survival for Advanced Non-Small-Cell Lung Cancer with Early Metabolic Progression after Immunotherapy Initiation.

Authors: Janho dit Hreich, Serena^1,2 (AUTHOR) serenahreich@gmail.com, Humbert, Olivier^3,4 (AUTHOR) olivier.humbert@nice.unicancer.fr, Pacé-Loscos, Tanguy⁵ (AUTHOR) tanguy.pace-loscos@nice.unicancer.fr, Schiappa, Renaud⁵ (AUTHOR) renaud.schiappa@nice.unicancer.fr, Juhel, Thierry¹ (AUTHOR) thierry.juhel@univ-cotedazur.fr, Ilié, Marius^1,2,6,7 (AUTHOR) ilie.m@chu-nice.fr, Ferrari, Victoria⁸ (AUTHOR), Benzaquen, Jonathan^1,2,6 (AUTHOR) hofman.p@chu-nice.fr, Hofman, Paul^1,2,6,7 (AUTHOR), Vouret-Craviari, Valérie^1,2,6 (AUTHOR) valerie.vouret@univ-cotedazur.fr

Source: Cancers. Jun2024, Vol. 16 Issue 12, p2226. 16p.

Subject Terms: *ADENOCARCINOMA, *CANCER invasiveness, *IMMUNOTHERAPY, *ENZYME-linked immunosorbent assay, *NEUTROPHILS, *TUMOR markers, *CELLULAR signal transduction, *IMMUNE checkpoint inhibitors, *LUNG cancer, *SURVIVAL analysis (Biometry), *INTERLEUKINS, *DISEASE progression, *OVERALL survival

Survival analysis of patient groups defined by unsupervised machine learning clustering methods based on patient metabolomic data.

Authors: Bailleux, Caroline, Chardin, David, Guigonis, Jean-Marie, Ferrero, Jean-Marc, Chateau, Yann, Humbert, Olivier, Pourcher, Thierry, Gal, Jocelyn

Source: In Computational and Structural Biotechnology Journal 2023 21:5136-5143

Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells

Authors: El-Kharrag, Rkia, Berckmueller, Kurt E., Madhu, Ravishankar, Cui, Margaret, Campoy, Gabriela, Mack, Heather M., Wolf, Carl B., Perez, Anai M., Humbert, Olivier, Kiem, Hans-Peter, Radtke, Stefan

Source: In Molecular Therapy 1 June 2022 30(6):2186-2198

Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells

Authors: Peterson, Christopher W., Venkataraman, Rasika, Reddy, Sowmya S., Pande, Dnyanada, Enstrom, Mark R., Radtke, Stefan, Humbert, Olivier, Kiem, Hans-Peter

Source: In Molecular Therapy - Methods & Clinical Development 10 March 2022 24:30-39

GridNet with automatic shape prior registration for automatic MRI cardiac segmentation

Authors: Zotti, Clement, Luo, Zhiming, Lalande, Alain, Humbert, Olivier, Jodoin, Pierre-Marc

Subject Terms: Computer Science - Computer Vision and Pattern Recognition

Access URL: http://arxiv.org/abs/1705.08943

Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations

Authors: Samuelson, Clare, Radtke, Stefan, Zhu, Haiying, Llewellyn, Mallory, Fields, Emily, Cook, Savannah, Huang, Meei-Li W., Jerome, Keith R., Kiem, Hans-Peter, Humbert, Olivier

Source: In Molecular Therapy - Methods & Clinical Development 10 December 2021 23:507-523

Genome editing in large animal models

Authors: Maynard, Lucy H., Humbert, Olivier, Peterson, Christopher W., Kiem, Hans-Peter

Source: In Molecular Therapy 3 November 2021 29(11):3140-3152

AMD3100 redosing fails to repeatedly mobilize hematopoietic stem cells in the nonhuman primate and humanized mouse

Authors: Samuelson, Clare, Radtke, Stefan, Cui, Margaret, Perez, Anai, Kiem, Hans-Peter, Humbert, Olivier

Source: In Experimental Hematology January 2021 93:52-60

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Authors: Srikanthan, Meera A., Humbert, Olivier, Haworth, Kevin G., Ironside, Christina, Rajawat, Yogendra S., Blazar, Bruce R., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P., Scadden, David T., Kiem, Hans-Peter

Source: In Molecular Therapy - Methods & Clinical Development 12 June 2020 17:455-464

Mouse models in hematopoietic stem cell gene therapy and genome editing

Authors: Radtke, Stefan, Humbert, Olivier, Kiem, Hans-Peter

Source: In Biochemical Pharmacology April 2020 174

Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer

Authors: Gal, Jocelyn, Bailleux, Caroline, Chardin, David, Pourcher, Thierry, Gilhodes, Julia, Jing, Lun, Guigonis, Jean-Marie, Ferrero, Jean-Marc, Milano, Gerard, Mograbi, Baharia, Brest, Patrick, Chateau, Yann, Humbert, Olivier, Chamorey, Emmanuel

Source: In Computational and Structural Biotechnology Journal 2020 18:1509-1524

RGD-functionalized magnetosomes are efficient tumor radioenhancers for X-rays and protons

Authors: Hafsi, Maha, Preveral, Sandra, Hoog, Christopher, Hérault, Joel, Perrier, Géraldine Adryanczyk, Lefèvre, Christopher T, Michel, Hervé, Pignol, David, Doyen, Jérôme, Pourcher, Thierry, Humbert, Olivier, Thariat, Juliette, Cambien, Béatrice

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine January 2020 23

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Authors: Lux, Christopher T., Pattabhi, Sowmya, Berger, Mason, Nourigat, Cynthia, Flowers, David A., Negre, Olivier, Humbert, Olivier, Yang, Julia G., Lee, Calvin, Jacoby, Kyle, Bernstein, Irwin, Kiem, Hans-Peter, Scharenberg, Andrew, Rawlings, David J.

Source: In Molecular Therapy - Methods & Clinical Development 15 March 2019 12:175-183