Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium

Authors: Darja Marolt Presen, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra-Larissa Stetco, Anja Tansek, Laura Pozenel, Bella Bruszel, Goran Mitulovic, Johannes Oesterreicher, Johannes Zipperle, Barbara Schaedl, Wolfgang Holnthoner, Johannes Grillari, Heinz Redl

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)

Subject Terms: Conditioned medium, Secretome, Human iPSCs, Human bone marrow mesenchymal stromal cells, Mesenchymal progenitors, Osteogenic differentiation, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/5f30f58b46244a1a9d29c678452bb930

Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model

Authors: Satish Kumar, Miriam Aceves, Jose Granados, Lorena Guerra, Felicia Juarez, Earl Novilla, Ana C. Leandro, Marcelo Leandro, Juan Peralta, Sarah Williams-Blangero, Elda E. Sanchez, Jacob A. Galan, John Blangero, Joanne E. Curran

Source: Biomolecules, Vol 15, Iss 3, p 381 (2025)

Subject Terms: human iPSCs, NSCs, Mojave rattlesnake venom, neurocellular response, molecular mechanisms, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/3/381; https://doaj.org/toc/2218-273X

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Lineage‐Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production

Authors: Tackla Winston, Yuanhui Song, Huaiyu Shi, Junhui Yang, Munther Alsudais, Maria I. Kontaridis, Yaoying Wu, Thomas R. Gaborski, Qinghe Meng, Robert N. Cooney, Zhen Ma

Source: Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)

Subject Terms: extracellular vesicles, human iPSCs, mesenchymal stromal cells, transcriptomics, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/c3c1a98291a240ac8fb96bf60b6ff868

Effect of gut microbiota-derived metabolites and extracellular vesicles on neurodegenerative disease in a gut-brain axis chip

Authors: Na Yeon Kim, Ho Yeon Lee, Yoon Young Choi, Sung Jun Mo, Soomin Jeon, Jang Ho Ha, Soo Dong Park, Jae-Jung Shim, Jaehwan Lee, Bong Geun Chung

Source: Nano Convergence, Vol 11, Iss 1, Pp 1-13 (2024)

Subject Terms: Gut-brain axis chip, Human iPSCs, Neural differentiation, Metabolites, Extracellular vesicles, Exosome, Technology, Chemical technology, TP1-1185, Biotechnology, TP248.13-248.65, Science, Physics, QC1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2196-5404

Access URL: https://doaj.org/article/90c4944080024af08c83b53d6c9dcaf5

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential

Authors: Rosa A. van Amerongen, Laura T. Morton, Umesh G. Chaudhari, Dennis F.G. Remst, Renate S. Hagedoorn, Cathelijne W. van den Berg, Christian Freund, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk

Source: Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 249-261 (2023)

Subject Terms: TCR gene transfer, adoptive T cell therapy, human iPSCs, preclinical screening, toxicity, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050123000074; https://doaj.org/toc/2329-0501

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Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Authors: Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero

Source: Stem Cell Reports, Vol 18, Iss 1, Pp 205-219 (2023)

Subject Terms: neural stem cells, neuronal networks, human cellular models, calcium imaging, functional connectivity, human iPSCs, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213671122005471; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/962ce87c1e414f1eb010c6a04fda8b20

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Authors: Hafiza Nosheen Saleem, Nadezda Ignatyeva, Christiaan Stuut, Stefan Jakobs, Michael Habeck, Antje Ebert

Source: Cells, Vol 13, Iss 11, p 923 (2024)

Subject Terms: endosomes, human iPSCs, computational modelling, signal processing, signal transduction, STED, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/11/923; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/3b730f7ae6354b759a23f3445aeabccb

Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells

Authors: Asato Sekiya, Ken Takasawa, Yoshikazu Arai, Shin-ichi Horike, Hidenori Akutsu, Akihiro Umezawa, Koichiro Nishino

Source: Regenerative Therapy, Vol 21, Iss , Pp 620-630 (2022)

Subject Terms: Human iPSCs, Neural stem cells, DNA methylation, Differentiation propensity, Machine learning, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352320422001122; https://doaj.org/toc/2352-3204

Access URL: https://doaj.org/article/713ff3db5b2d4258af590dc1c99b51be

A robust and reliable methodology to perform GECI-based multi-time point neuronal calcium imaging within mixed cultures of human iPSC-derived cortical neurons

Authors: Niraj Patel, Vincent Ouellet, François Paquet-Mercier, Nizar Chetoui, Erik Bélanger, Marie-Eve Paquet, Antoine G. Godin, Pierre Marquet

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: human iPSCs (induced pluripotent stem cells), neurodifferentiation, GECI (genetically encoded Ca2+ indicator), human synapsin1 (hSyn) promoter, CAG promoter, calcium imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1247397/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/d75bcabef3a94510a2a7462309492018

Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application

Authors: Yuko Kitano, Sayaka Nishimura, Tomoaki M. Kato, Anna Ueda, Kaho Takigawa, Masafumi Umekage, Masaki Nomura, Ayane Kawakami, Haruna Ogawa, Huaigeng Xu, Akitsu Hotta, Naoko Takasu, Masayoshi Tsukahara

Source: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 15-25 (2022)

Subject Terms: CRISPR-Cas9, human iPSCs, HLA-A, HLA-B, CIITA, GMP, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122000754; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/94c9d417429446f8b649414f61abd42a

From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases

Authors: Debia Wakhloo, Jane Oberhauser, Angela Madira, Sameehan Mahajani

Source: Neural Regeneration Research, Vol 17, Iss 12, Pp 2606-2614 (2022)

Subject Terms: alpha-synuclein, amyloid beta plaques, autophagy, dopaminergic neurons, human ipscs, mitochondrial dysfunction, scrna sequencing, synaptic dysfunction, tau, wallerian degeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2606;epage=2614;aulast=Wakhloo; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/9d407ef1ed834b699fc63e1c81c9b3e8

Use of in vitro derived human neuronal models to study host-parasite interactions of Toxoplasma gondii in neurons and neuropathogenesis of chronic toxoplasmosis

Authors: Sandra K. Halonen

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: human neurons, human iPSCs, spontaneous cystogenesis, bradyzoites, cerebral organoids, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1129451/full; https://doaj.org/toc/2235-2988

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Human Induced Pluripotent Spheroids’ Growth Is Driven by Viscoelastic Properties and Macrostructure of 3D Hydrogel Environment

Authors: Lucas Lemarié, Tanushri Dargar, Isabelle Grosjean, Vincent Gache, Edwin J. Courtial, Jérôme Sohier

Source: Bioengineering, Vol 10, Iss 12, p 1418 (2023)

Subject Terms: human iPSCs, spheroids, growth, stem cells, hydrogel, viscoelastic properties, Technology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2306-5354/10/12/1418; https://doaj.org/toc/2306-5354

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Characterization of a Human Neuronal Culture System for the Study of Cofilin–Actin Rod Pathology

Authors: Lubna H. Tahtamouni, Sydney A. Alderfer, Thomas B. Kuhn, Laurie S. Minamide, Soham Chanda, Michael R. Ruff, James R. Bamburg

Source: Biomedicines, Vol 11, Iss 11, p 2942 (2023)

Subject Terms: cofilin, cofilactin rods, human iPSCs, WTC-11 cells, amyloid-β, cellular prion protein, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/2227-9059/11/11/2942; https://doaj.org/toc/2227-9059

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Single-cell transcriptomic profiling reveals specific maturation signatures in human cardiomyocytes derived from LMNB2-inactivated induced pluripotent stem cells

Authors: Jie Wang, William Morgan, Ankur Saini, Tao Liu, John Lough, Lu Han

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: cardiomyocyte maturation, human iPSCs, single-cell RNA-seq, Lmnb2, proliferation, human fetal heart, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.895162/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/d5279ecaee6e48a79bec55869173bad6

Biphasic cell cycle defect causes impaired neurogenesis in down syndrome

Authors: Vishi Sharma, Sunita Nehra, Long H. Do, Anwesha Ghosh, Aniruddha J. Deshpande, Nishant Singhal

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: down syndrome, neurogenesis, cell cycle, disease modeling, mouse iPSCs, human iPSCs, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.1007519/full; https://doaj.org/toc/1664-8021

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The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation

Authors: Nadja Gustavsson, Ekaterina Savchenko, Oxana Klementieva, Laurent Roybon

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-6 (2021)

Subject Terms: Parkinson’s disease, Protein aggregation, Alpha-synuclein, Cellular environment, Human iPSCs, Midbrain spheroids, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/53851b3c6282414381aae42ec9308475

Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons

Authors: Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler, Ana Garcera

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)

Subject Terms: Spinal muscular atrophy, Survival motor neuron, Autophagy, Neuromuscular disease, Human iPSCs, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/6519b01e036441a5a70343d791779e8b

Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD

Authors: Danijela Drakulic, Srdjan Djurovic, Yasir Ahmed Syed, Sebastiano Trattaro, Nicolò Caporale, Anna Falk, Rivka Ofir, Vivi M. Heine, Samuel J. R. A. Chawner, Antonio Rodriguez-Moreno, Marianne B. M. van den Bree, Giuseppe Testa, Spyros Petrakis, Adrian J. Harwood

Source: Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)

Subject Terms: Human iPSCs, Copy number variants (CNVs), Neurodevelopmental disorders (NDD), Autism spectrum disorders (ASD), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13229-020-00343-4; https://doaj.org/toc/2040-2392

Access URL: https://doaj.org/article/d4e8450a48824f23b625b697df32b39b

Cerebral Malaria Model Applying Human Brain Organoids

Authors: Rita Silva-Pedrosa, Jonas Campos, Aline Marie Fernandes, Miguel Silva, Carla Calçada, Ana Marote, Olga Martinho, Maria Isabel Veiga, Ligia R. Rodrigues, António José Salgado, Pedro Eduardo Ferreira

Source: Cells, Vol 12, Iss 7, p 984 (2023)

Subject Terms: cerebral malaria, brain organoids, transcriptome, human iPSCs, secretome, HBMEC activation, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/7/984; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/cd08232ab7c947eb982dcc92cad2afb1