Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer

Authors: Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li

Source: mAbs, Vol 16, Iss 1 (2024)

Subject Terms: Antibody drug conjugate, fully human antibody, monomethyl auristatin E, prostate cancer, PSCA, tumor xenograft mouse model, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/1f085d6811ce4dcda8bde14f50a5302f

Fully human monoclonal antibodies against Ebola virus possess complete protection in a hamster model

Authors: Wujian Li, Wanying Yang, Xueqin Liu, Wujie Zhou, Shen Wang, Zhenshan Wang, Yongkun Zhao, Na Feng, Tiecheng Wang, Meng Wu, Liangpeng Ge, Xianzhu Xia, Feihu Yan

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: Ebola virus disease, Ebola virus, neutralizing antibodies, fully human antibody, transgenic mice, surrogate model, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/8eda2434f93341e8b1ad66aa4b641510

Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

Authors: Ray, Rashmi ^{1, 9}, Nait Mohamed, Faez Amokrane ^{1, 9, ∗}, Maurer, Daniel P. ^{1, 9}, Huang, Jiachen ^{2, 9}, Alpay, Berk A. ^{3, 4}, Ronsard, Larance ¹, Xie, Zhenfei ¹, Han, Julianna ², Fernandez-Quintero, Monica ^{2, 5}, Phan, Quynh Anh ¹, Ursin, Rebecca L. ¹, Vu, Mya ¹, Kirsch, Kathrin H. ¹, Prum, Thavaleak ¹, Rosado, Victoria C. ¹, Bracamonte-Moreno, Thalia ¹, Okonkwo, Vintus ¹, Bals, Julia ¹, McCarthy, Caitlin ¹, Nair, Usha ¹, Kanekiyo, Masaru ⁶, Ward, Andrew B. ², Schmidt, Aaron G. ^{1, 7, ∗∗}, Batista, Facundo D. ^{1, 8, ∗∗∗}, Lingwood, Daniel ^{1, 10, ∗∗∗∗}

Source: In Immunity 14 May 2024 57(5):1141-1159

High-Affinity Fully Human Anti-EpCAM Antibody with Biased IL-2 Exhibits Potent Antitumor Activity

Authors: Zhi Wang, Mingkai Wang, Quanxiao Li, Yanling Wu, Tianlei Ying

Source: Biomolecules, Vol 14, Iss 11, p 1399 (2024)

Subject Terms: fully human antibody, EpCAM, biased IL-2 variant, immunocytokine, anti-tumor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/11/1399; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/4b8c2679e6ee4da29119a3015d185635

A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein

Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala, Dinakar M. Salunke

Source: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)

Subject Terms: Influenza virus, M2 ion channel protein and M2e dimerization, Naive human antibody scFv library, Co-crystallization, Virus regression, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/b4f6f21538a148df8eb8c55019058108

Broadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2

Authors: Hsiao-Ling Chiang, Kang-Hao Liang, Ruei-Min Lu, Ting-Wen Kuo, Yi‑Ling Lin, Han-Chung Wu

Source: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-13 (2023)

Subject Terms: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Omicron, XBB.1.5, BQ.1.1, Single B cell cloning, Neutralizing human antibody, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/1d7d961b78ef45e7a75d8ce24417a532

A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

Authors: Yang Qin, Gan Wu, Jiayi Jin, Hao Wang, Jiani Zhang, Li Liu, Heping Zhao, Jianguang Wang, Xinyu Yang

Source: BMC Biotechnology, Vol 23, Iss 1, Pp 1-12 (2023)

Subject Terms: CTGF, Phage display, Affinity maturation, Angiogenesis, Arthritis, Human antibody, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6750

Access URL: https://doaj.org/article/4a0a84e26e964c38b6afa0e402c8d31b

Anti-ricin toxin human neutralizing antibodies and DMAbs protection against ricin toxin poisoning

Authors: Yu, Haotian ^{a, 1}, Wu, Meng ^{b, 1}, Zhao, Na ^a, Dong, Mingxin ^a, Wang, Yan ^{a, d}, Yu, Kaikai ^a, Sun, Chengbiao ^a, Xu, Na ^{a, c, ⁎}, Ge, Liangpeng ^{b, ⁎⁎}, Liu, Wensen ^{a, ⁎⁎}

Source: In Toxicology Letters 1 July 2023 383:152-161

Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0

Contributors: Ruvo, Menotti, Sandomenico, Annamaria

Subject Terms: PRAME, mAb, bio-layer interferometry, epitope identification, monoclonal antibody, free radical, protein aggregation, oxidation, excipient, foot-and-mouth disease virus, type O, type A, phage display, antibody, competitive ELISA, atherosclerosis, nano-emulsion, magnetic resonance imaging, stealth, human antibody, C. auris, candidiasis, multidrug resistance, monoclonal antibodies, universal antibodies, cell wall, passive immunization, cell-based panning, semi-automated cell panning, FGFR3-specific antibody, Research and information: general, Biology, life sciences

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/79602
https://mdpi.com/books/pdfview/book/4986

Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice

Authors: Qiuli Tong, Hu Liu, Qianqian Qi, Chaohui Dai, Teddy Yang, Feng Qian

Source: FEBS Open Bio, Vol 12, Iss 8, Pp 1542-1557 (2022)

Subject Terms: engineering modification, fully human antibody, GITR, H2L2 mice, immunization strategies, T cell, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/18c31dff14264b6bb4e923947ba750a3

A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Authors: Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen, Jiannan Feng

Source: Engineering, Vol 7, Iss 11, Pp 1566-1576 (2021)

Subject Terms: HER2/erb-B2, Human antibody, Computer-aided design, Engineering (General). Civil engineering (General), TA1-2040

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2095809921003829; https://doaj.org/toc/2095-8099

Access URL: https://doaj.org/article/e70c033ea5d74155a0ed00602f742efe

Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis

Authors: Gyeong Min Kim, Doo Ri Park, Thi Thu Ha Nguyen, Jiseon Kim, Jihee Kim, Myung-Ho Sohn, Won-Kyu Lee, Soo Young Lee, Hyunbo Shim

Source: Biomedicines, Vol 11, Iss 10, p 2844 (2023)

Subject Terms: OSCAR, osteoarthritis, human antibody, chondrocyte, disease-modifying osteoarthritis drugs, DMOAD, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/10/2844; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/5b2e284499bd4a42b5680439ca38020a

Discovery and characterization of SARS-CoV-2 reactive and neutralizing antibodies from humanized CAMouseHG mice through rapid hybridoma screening and high-throughput single-cell V(D)J sequencing

Authors: Xi Yang, Hang Chi, Meng Wu, Zhenshan Wang, Qiaoli Lang, Qiuxue Han, Xinyue Wang, Xueqin Liu, Yuanguo Li, Xiwen Wang, Nan Huang, Jinhao Bi, Hao Liang, Yuwei Gao, Yongkun Zhao, Na Feng, Songtao Yang, Tiecheng Wang, Xianzhu Xia, Liangpeng Ge

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: SARS-CoV-2, reactive and neutralizing antibodies, fully human antibody, antibody humanized mice, single-cell sequencing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.992787/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/84a77eb83db04e2f92ca08917dd13038

The first results of combined treatment of giant cell tumor of bone

Authors: A. A. Barashev, V. V. Mozulyaka, T. V. Ausheva, Yu. R. Vinnik, L. N. Vashchenko, E. M. Nepomnyashchaya, P. V. Chernogorov

Source: Южно-Российский онкологический журнал, Vol 1, Iss 4, Pp 6-14 (2020)

Subject Terms: giant cell tumor of bone, denosumab, targeted therapy, therapeutic pathomorphosis, tumor sclerosis, a monoclonal human antibody, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.cancersp.com/jour/article/view/83; https://doaj.org/toc/2686-9039

Access URL: https://doaj.org/article/2af999df28854f42b09be8a5cd59d316

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens

Authors: Taushif Khan, Mahbuba Rahman, Ikhlak Ahmed, Fatima Al Ali, Puthen Veettil Jithesh, Nico Marr

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: human antibody repertoires, microbial infection, phage immunoprecipitation sequencing, human leukocyte antigen, major histocompatibility complex, polymorphisms, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.856497/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9e0450544bb94672b3c0bf4034833577

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Authors: Xianglei Liu, Doncho Zhelev, Cynthia Adams, Chuan Chen, John W Mellors, Dimiter S. Dimitrov

Source: Translational Oncology, Vol 14, Iss 12, Pp 101232- (2021)

Subject Terms: Fully human antibody, CD276 (B7-H3), V1/V2 domain, Bispecific T cell engager (BiTE), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523321002242; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/18f0eddf10344c4f99fa93efd581e9e7

Development of therapeutic antibodies for the treatment of diseases

Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li, Han-Chung Wu

Source: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-30 (2020)

Subject Terms: Therapeutic antibody, Antibody market, Humanized antibody, Phage display, Human antibody mouse, Single B cell antibody technology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/6c12fb76198c44a2ab82a436f99b3caa

Development and Characterization of Phage-Display-Derived Novel Human Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2

Authors: Ji Woong Kim, Sung Won Min, Jichul Lee, Ha Gyeong Shin, Hye Lim Choi, Ha Rim Yang, Ji Hyun Lee, Yea Bin Cho, Hyunbo Shim, Sukmook Lee

Source: Biomedicines, Vol 10, Iss 12, p 3274 (2022)

Subject Terms: SARS-CoV-2, human antibody, neutralization, sandwich ELISA, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/12/3274; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/49995521da52459c87d00f4dcb6c5a2a

Development of a novel, fully human, anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy

Authors: Menglong Xu, Gaoxin Lei, Manman Chen, Ke Wang, Wenxiu Lv, Panpan Zhang, Tuo Hu, Jie Gao, Chenchen Lu, Ying Mei, Zhipan Xu, Zhengli Bai, Huajing Hu, Yiwei Jiang, Shuhua Tan

Source: EBioMedicine, Vol 65, Iss , Pp 103250- (2021)

Subject Terms: PCSK9, Phage display, Human antibody, Affinity maturation, Hypercholesterolemia, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421000438; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/094aaa9f204d43388be2794845df7232

Bactericidal fully human single‐chain fragment variable antibodies protect mice against methicillin‐resistant Staphylococcus aureus bacteraemia

Authors: Behnoush Soltanmohammadi, Somayeh Piri‐Gavgani, Eilnaz Basardeh, Mostafa Ghanei, Masoumeh Azizi, Zabihollah Khaksar, Zahra Sharifzadeh, Farzad Badmasti, Mahdieh Soezi, Abolfazl Fateh, Parisa Azimi, Seyed Davar Siadat, Fahimeh Shooraj, Saeid Bouzari, Mir Davood Omrani, Fatemeh Rahimi‐Jamnani

Source: Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)

Subject Terms: bacteraemia, bactericidal antibodies, fully human antibody, methicillin‐resistant Staphylococcus aureus, single‐chain fragment variable, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/fa048c50d35b40f3a5e39362654fb69b