Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics

Authors: Nye, Taylor M., Tükenmez, Hasan, Singh, Pardeep, Flores-Mireles, Ana L., Obernuefemann, Chloe L. P., Pinkner, Jerome S., Sarkar, Souvik, Bonde, Mari, Lindgren, Anders E. G., Dodson, Karen W., Johansson, Jörgen, Almqvist, Fredrik, Caparon, Michael G., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Oct . 119(43), 1-10.

Access URL: https://www.jstor.org/stable/27208914

Characterization of Host-Pathogen-Device Interactions in Pseudomonas aeruginosa Infection of Breast Implants

Authors: Vuong, Linh N., Dorsey, Denise, Obernuefemann, Chloe, Pinkner, Jerome, Walker, Jennifer N., Hultgren, Scott, Myckatyn, Terence M.

Source: Plastic and reconstructive surgery. 150(2):260e-271e

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167698355.0x000001&indx=1&recIds=ETOCvdc_100167698355.0x000001

Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS)

Authors: Ratnayake, Anokha S., Flanagan, Mark E., Foley, Timothy L., Hultgren, Scott L., Bellenger, Justin, Montgomery, Justin I., Lall, Manjinder S., Liu, Bo, Ryder, Tim, Kölmel, Dominik K., Shavnya, Andre, Feng, Xidong, Lefker, Bruce, Byrnes, Laura J., Sahasrabudhe, Parag V., Farley, Kathleen A., Chen, Shi, Wan, Jinqiao

Source: In Bioorganic & Medicinal Chemistry 1 July 2021 41

Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili.

Authors: Bitter, Ryan M., Zimmerman, Maxwell I., Summers, Brock T., Pinkner, Jerome S., Dodson, Karen W., Hultgren, Scott J., Peng Yuan

Source: Proceedings of the National Academy of Sciences of the United States of America; 10/1/2024, Vol. 121 Issue 40, p1-7, 15p

Subject Terms: URINARY tract infections, QUATERNARY structure, VIRAL tropism, EXTRACELLULAR space, GRAM-negative bacteria

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

Authors: Flentie, Kelly, Harrison, Gregory A., Tükenmez, Hasan, Livny, Jonathan, Good, James A. D., Sarkar, Souvik, Zhu, Dennis X., Kinsella, Rachel L., Weiss, Leslie A., Solomon, Samantha D., Schene, Miranda E., Hansen, Mette R., Cairns, Andrew G., Kulén, Martina, Wixe, Torbjörn, Lindgren, Anders E. G., Chorell, Erik, Bengtsson, Christoffer, Krishnan, K. Syam, Hultgren, Scott J., Larsson, Christer, Almqvist, Fredrik, Stallings, Christina L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 May . 116(21), 10510-10517.

Access URL: https://www.jstor.org/stable/26706280

High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration

Authors: Walker, Jennifer N., Flores-Mireles, Ana L., Lynch, Aaron J. L., Pinkner, Chloe, Caparon, Michael G., Hultgren, Scott J., Desai, Alana

Source: World journal of urology. 38(9):2237-2245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167932889.0x000001&indx=1&recIds=ETOCvdc_100167932889.0x000001

Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis

Authors: Walker, Jennifer N, Pinkner, Chloe L, Lynch, Aaron J L, Ortbal, Sarah, Pinkner, Jerome S, Hultgren, Scott J, Myckatyn, Terence M

Source: Aesthetic surgery journal. 40(3):281-295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098843098.0x000001&indx=1&recIds=ETOCvdc_100098843098.0x000001

Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis.

Authors: Lopatto, Edward D. B., Pinkner, Jerome S., Sanick, Denise A., Potter, Robert F., Liu, Lily X., Bazán Villicaña, Jesús, Tamadonfar, Kevin O., Yijun Ye, Zimmerman, Maxwell I., Gualberto, Nathaniel C., Dodson, Karen W., Janetka, James W., Hunstad, David A., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/24/2024, Vol. 121 Issue 39, p1-10, 29p

Subject Terms: URINARY tract infections, ESCHERICHIA coli, IMPLANTABLE catheters, KLEBSIELLA pneumoniae, BACTERIAL colonies

The Extracytoplasmic Adaptor Protein CpxP Is Degraded with Substrate by DegP

Authors: Pinkner, Jerome S., Hultgren, Scott J., Silhavy, Thomas J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Dec 01. 102(49), 17775-17779.

Access URL: https://www.jstor.org/stable/4152803

Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma

Authors: Walker, Jennifer, Hanson, Blake, Pinkner, Chloe, Simar, Shelby, Pinkner, Jerome, Parikh, Rajiv, Clemens, Mark, Hultgren, Scott, Myckatyn, Terence

Source: Scientific reports. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185511816.0x000001&indx=1&recIds=ETOCvdc_100185511816.0x000001

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Authors: Di Venanzio, Gisela, Flores-Mireles, Ana, Calix, Juan, Haurat, M., Scott, Nichollas, Palmer, Lauren, Potter, Robert, Hibbing, Michael, Friedman, Laura, Wang, Bin, Dantas, Gautam, Skaar, Eric, Hultgren, Scott, Feldman, Mario

Source: Nature communications. 10(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181236133.0x000001&indx=1&recIds=ETOCvdc_100181236133.0x000001

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

Authors: Kalas, Vasilios, Hibbing, Michael E., Maddirala, Amarendar Reddy, Chugani, Ryan, Pinkner, Jerome S., Mydock-McGrane, Laurel K., Conover, Matt S., Janetka, James W., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar . 115(12), E2819-E2828.

Access URL: https://www.jstor.org/stable/26509054

Catalysis of Protein Folding by Chaperones in Pathogenic Bacteria

Authors: Bann, James G., Pinkner, Jerome S., Frieden, Carl, Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Dec . 101(50), 17389-17393.

Access URL: https://www.jstor.org/stable/3374081

Differentiation and Developmental Pathways of Uropathogenic Escherichia coli in Urinary Tract Pathogenesis

Authors: Justice, Sheryl S., Hung, Chia, Theriot, Julie A., Fletcher, Daniel A., Anderson, Gregory G., Footer, Matthew J., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Feb 01. 101(5), 1333-1338.

Access URL: https://www.jstor.org/stable/3148835

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Authors: Walker, Jennifer N., Flores-Mireles, Ana L., Pinkner, Chloe L., Schreiber, Henry L., Joens, Matthew S., Park, Alyssa M., Potretzke, Aaron M., Bauman, Tyler M., Pinkner, Jerome S., Fitzpatrick, James A. J., Desai, Alana, Caparon, Michael G., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Oct 01. 114(41), E8721-E8730.

Access URL: https://www.jstor.org/stable/26488727

Toll-like Receptor 4 on Stromal and Hematopoietic Cells Mediates Innate Resistance to Uropathogenic Escherichia coli

Authors: Schilling, Joel D., Martin, Steven M., Hung, Chia S., Lorenz, Robin G., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Apr 01. 100(7), 4203-4208.

Access URL: https://www.jstor.org/stable/3148764

Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation

Authors: Chapman, Matthew R., Robinson, Lloyd S., Pinkner, Jerome S., Roth, Robyn, Heuser, John, Hammar, Mårten, Normark, Staffan, Hultgren, Scott J.

Source: Science, 2002 Feb 01. 295(5556), 851-855.

Access URL: https://www.jstor.org/stable/3075754

Real-Time and Equilibrium 19 F-NMR Studies Reveal the Role of Domain-Domain Interactions in the Folding of the Chaperone PapD

Authors: Bann, James G., Pinkner, Jerome, Hultgren, Scott J., Frieden, Carl

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Jan . 99(2), 709-714.

Access URL: https://www.jstor.org/stable/3057630

Snapshots of Usher-Mediated Protein Secretion and Ordered Pilus Assembly

Authors: Saulino, Evan T., Bullitt, Esther, Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2000 Aug 01. 97(16), 9240-9245.

Access URL: https://www.jstor.org/stable/123160

Bad Bugs and Beleaguered Bladders: Interplay between Uropathogenic Escherichia coli and Innate Host Defenses

Authors: Mulvey, Matthew A., Schilling, Joel D., Martinez, Juan J., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2000 Aug 01. 97(16), 8829-8835.

Access URL: https://www.jstor.org/stable/123089