Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway

Authors: Wenkang Gao, Gang Wang, Hang Yuan, Yue Chen, Jiake Che, Zilu Cheng, Liuying Chen, Li Zhang, Yuanqing Zhu, Xin Liu, Ao Liu, Quancheng Yang, Peng Cao, Wei Qian, Weiyan Huang, Bernd Schnabl, Ling Yang, Huikuan Chu

Source: Cell & Bioscience, Vol 15, Iss 1, Pp 1-19 (2025)

Subject Terms: Acetaminophen, Dysbiosis, Probiotics, Gut-liver axis, Branched-chain amino acids, Gut microbiome, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/c03b6f835b594b4f9469c6911e625195

Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities

Authors: Yongpeng Shi, Zeran Chen, Tingyu Fang, Xingyao Chen, Youpeng Deng, Hao Qin, Min Lian, Juntao Shen, Yuru Zong, Huikuan Chu, Constanze Hoebinger, Hao Guo, Zhongshang Yuan, Jie Zheng, Yongjian Zhou, Yue Pan, Beatriz G. Mendes, Sonja Lang, Tim Hendrikx, Suling Zeng, Hailong Cao, Ling Yang, Lianmin Chen, Peng Chen, Lei Dai, Hua Wang, Shi Yin, Shu Zhu, Xiong Ma, Bernd Schnabl, Hanqing Chen, Yi Duan

Source: iMeta, Vol 4, Iss 1, Pp n/a-n/a (2025)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://doaj.org/toc/2770-596X

Access URL: https://doaj.org/article/c5b579ffd90c4c1aa0bf7de7a3a4785c

Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets

Authors: Zilu Cheng, Yixiong Chen, Bernd Schnabl, Huikuan Chu, Ling Yang

Source: Journal of Advanced Research, Vol 59, Iss , Pp 173-187 (2024)

Subject Terms: Bile acid, Takeda G-protein coupled receptor 5, farnesoid X receptor, Dysbiosis, Nonalcoholic hepatitis, Medicine (General), R5-920, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S209012322300173X; https://doaj.org/toc/2090-1232

Access URL: https://doaj.org/article/13e6917baa1d422f8bb1cfb51fabe57b

Hepatocyte programmed cell death: the trigger for inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis

Authors: Zilu Cheng, Huikuan Chu, Ekihiro Seki, Rong Lin, Ling Yang

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: programmed cell death, metabolic dysfunction-associated steatohepatitis, metabolic disorders, hepatic inflammation, hepatic fibrosis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1431921/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/cc738f65fed5443b821287d8765750b6

Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease

Authors: Wei Li, Wenkang Gao, Shengqi Yan, Ling Yang, Qingjing Zhu, Huikuan Chu

Source: Biomedicines, Vol 13, Iss 1, p 74 (2024)

Subject Terms: alcohol-related liver disease, gut microbiota, gut microbiota metabolites, intestinal barrier, gut–liver axis, inflammatory response, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/13/1/74; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/3932d5eea90749e1834505eae93f6425

TRIF-dependent signaling and its role in liver diseases

Authors: Lilin Hu, Zilu Cheng, Huikuan Chu, Weijun Wang, Yu Jin, Ling Yang

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: TRIF, TLR3, TLR4, IFN-β response, NF-κB, apoptosis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1370042/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/97c0f88a411542cc9e8881517335c5ee

Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function

Authors: Liuying Chen, Pengcheng Yang, Lilin Hu, Ling Yang, Huikuan Chu, Xiaohua Hou

Source: Cell & Bioscience, Vol 13, Iss 1, Pp 1-17 (2023)

Subject Terms: Alcohol-related liver diseases, Phenylalanine metabolism, Lactobacillus acidophilus, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/6e21a75001a844839f0d3028d2cc502b

Acetate reprograms gut microbiota during alcohol consumption

Authors: Cameron Martino, Livia S. Zaramela, Bei Gao, Mallory Embree, Janna Tarasova, Seth J. Parker, Yanhan Wang, Huikuan Chu, Peng Chen, Kuei-Chuan Lee, Daniela Domingos Galzerani, Jivani M. Gengatharan, Asama Lekbua, Maxwell Neal, Rob Knight, Hidekazu Tsukamoto, Christian M. Metallo, Bernd Schnabl, Karsten Zengler

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/292675b6fc0d412ca90d9a63b7406e41

Hepatocyte TGF‐β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let‐7b‐5p

Authors: Jinfang Zhao, Lilin Hu, Wenfang Gui, Li Xiao, Weijun Wang, Jing Xia, Huiqian Fan, Zhonglin Li, Qingjing Zhu, Xiaohua Hou, Huikuan Chu, Ekihiro Seki, Ling Yang

Source: Hepatology Communications, Vol 6, Iss 6, Pp 1301-1321 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/83cc3555436e4e7b9c2abe829d37b932

Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications

Authors: Zilu Cheng, Huikuan Chu, Qingjing Zhu, Ling Yang

Source: Frontiers in Nutrition, Vol 10 (2023)

Subject Terms: ferroptosis, iron metabolism, nonalcoholic liver disease, time-restricted feeding, enoyl coenzyme A hydratase 1, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnut.2023.1090338/full; https://doaj.org/toc/2296-861X

Access URL: https://doaj.org/article/2d21baa5e8c54b0cbc885515f1eb50e9

CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

Authors: Yi Duan, Huikuan Chu, Katharina Brandl, Lu Jiang, Suling Zeng, Nairika Meshgin, Eleni Papachristoforou, Josepmaria Argemi, Beatriz G. Mendes, Yanhan Wang, Hua Su, Weizhong Sun, Cristina Llorente, Tim Hendrikx, Xiao Liu, Mojgan Hosseini, Tatiana Kisseleva, David A. Brenner, Ramon Bataller, Prakash Ramachandran, Michael Karin, Wenxian Fu, Bernd Schnabl

Source: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f7ec4d70456c4928accc2ab2a0cc002c

The critical role of gut microbiota in obesity

Authors: Zilu Cheng, Li Zhang, Ling Yang, Huikuan Chu

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: gut microbiota, obesity, energy homeostasis, bile acids, SCFAs, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.1025706/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/16edd15877404c088dd23053c605002e

The Crosstalk between Gut Microbiota and Bile Acids Promotes the Development of Non-Alcoholic Fatty Liver Disease

Authors: Zhonglin Li, Hang Yuan, Huikuan Chu, Ling Yang

Source: Microorganisms, Vol 11, Iss 8, p 2059 (2023)

Subject Terms: bile acid, bile acid receptor, gut microbiota, NAFLD, NAFLD treatment, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/11/8/2059; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/8e44011cda674f65b99c5be53e76113b

The Gut Microbiota: A Novel Player in Autoimmune Hepatitis

Authors: Zilu Cheng, Ling Yang, Huikuan Chu

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: intestinal microbiota, autoimmune hepatitis, gut-liver axis, probiotics, fecal microbiota transplantation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.947382/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/9f26d338314f40b49029e61eb7d9c928

The Novel Role of Phage Particles in Chronic Liver Diseases

Authors: Liuying Chen, Xiaohua Hou, Huikuan Chu

Source: Microorganisms, Vol 11, Iss 5, p 1181 (2023)

Subject Terms: virus, phage, chronic liver disease, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/11/5/1181; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/089f9b34bc8d4da083c040d075336113

The Role of Gut Bacteria and Fungi in Alcohol-Associated Liver Disease

Authors: Liuying Chen, Yixin Zhu, Xiaohua Hou, Ling Yang, Huikuan Chu

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: gut dysbiosis, fungi, alcohol-associated liver disease, gut-liver axis, intestinal barrier, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.840752/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/f1070a45fb31467d9ce29b2c6f36ec83

Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China

Authors: Huikuan Chu, Li Peng, Lilin Hu, Yixin Zhu, Jinfang Zhao, Hua Su, Lin Yao, Qingjing Zhu, Xiu Nie, Ling Yang, Xiaohua Hou

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: liver histopathological analysis, COVID-19 patients, transmission electron microscopy, edematous of mitochondria, expansions of endoplasmic reticulum, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.749318/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/754686fd8b0349e6b34d0918010dd697

Corrigendum: Multicenter Analysis of Liver Injury Patterns and Mortality in COVID-19

Authors: Huikuan Chu, Tao Bai, Liuying Chen, Lilin Hu, Li Xiao, Lin Yao, Rui Zhu, Xiaohui Niu, Zhonglin Li, Lei Zhang, Chaoqun Han, Shuangning Song, Qi He, Ying Zhao, Qingjing Zhu, Hua Chen, Bernd Schnabl, Ling Yang, Xiaohua Hou

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: liver impairment, hepatocellular pattern, cholestatic pattern, mixed pattern, prognosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.764493/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/aff15b9c125e438082b37dd69b0fab29

Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome

Authors: Ao Liu, Wenkang Gao, Yixin Zhu, Xiaohua Hou, Huikuan Chu

Source: Toxins, Vol 14, Iss 9, p 596 (2022)

Subject Terms: irritable bowel syndrome, microbiome, metabolites, diagnostic tests, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/14/9/596; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/90bbf929445d44d09e623093e9f70d21

Gut non-bacterial microbiota contributing to alcohol-associated liver disease

Authors: Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu

Source: Gut Microbes, Vol 13, Iss 1 (2021)

Subject Terms: alcohol-associated liver disease, gut-liver axis, gut barrier, liver sinusoid endothelial cells, mycobiome, clec7a, virome, archaeome, immune response, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/af59e97e962345bd97eef5d7f8648a82