Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer models

Authors: Lim, Jamie L. ^{1, 4}, Jensen, Stine Marie ^{1, 4}, Plomp, Jaap J. ², Vankerckhoven, Bernhardt ³, Kneip, Christa ³, Coppejans, Rani ³, Steyaert, Christophe ³, Moens, Kathleen ³, De Clercq, Lieselot ³, Tannemaat, Martijn R. ², Ulrichts, Peter ³, Silence, Karen ³, van der Maarel, Silvère M. ¹, Vergoossen, Dana L.E. ¹, Vanhauwaert, Roeland ³, Verschuuren, Jan J. ², Huijbers, Maartje G. ^{1, 2, 5, ∗}

Source: In iScience 21 February 2025 28(2)

Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development

Authors: Paardekooper, Laurent M., Fillié-Grijpma, Yvonne E., van der Sluijs-Gelling, Alita J., Zlei, Mihaela, van Doorn, Remco, Vermeer, Maarten H., Paunovic, Manuela, Titulaer, Maarten J., van der Maarel, Silvère M., van Dongen, Jacques J.M., Verschuuren, Jan J., Huijbers, Maartje G.

Source: In Clinical Immunology December 2023 257

Differences in IgG autoantibody Fab glycosylation across autoimmune diseases

Authors: Koers, Jana, Sciarrillo, Rocco, Derksen, Ninotska I.L., Vletter, Esther M., Fillié-Grijpma, Yvonne E., Raveling-Eelsing, Elisabeth, Graça, Nuno A.G., Leijser, Thiemo, Pas, Hendri H., Laura van Nijen-Vos, L., Braham, Maaike V.J., Buisman, Anne-Marie, de Jong, Jan, Schriek, Angela I., Tio-Gillen, Anne P., Teng, Y.K. Onno, Steenhuis, Maurice, Swaneveld, Francis H., de Taeye, Steven W., van Gils, Marit J., Verschuuren, Jan J.G.M., Rutgers, Bram, Heeringa, Peter, Horváth, Barbara, Jacobs, Bart C., de Leeuw, Karina, Franssen, Casper F.M., Veyradier, Agnès, Coppo, Paul, Gelderman, Kyra A., Marieke van Ham, S., van Els, Cécile A.C.M., van der Woude, Diane, Huizinga, Ruth, Huijbers, Maartje G., Kuijpers, Taco W., Toes, Rene E.M., Bos, Nicolaas A., Rispens, Theo

Source: In The Journal of Allergy and Clinical Immunology June 2023 151(6):1646-1654

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

Authors: Huijbers, Maartje G, Marx, Alexander, Plomp, Jaap J, Le Panse, Rozen, Phillips, William D

Source: Lancet neurology. 21(2):163-175

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155651425.0x000001&indx=1&recIds=ETOCvdc_100155651425.0x000001

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis

Authors: Vergoossen, Dana L. E., Plomp, Jaap J., Gstöttner, Christoph, Fillié-Grijpma, Yvonne E., Augustinus, Roy, Verpalen, Robyn, Wuhrer, Manfred, Parren, Paul W. H. I., Dominguez-Vega, Elena, van der Maarel, Silvère M., Verschuuren, Jan J., Huijbers, Maartje G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Mar . 118(13), 1-11.

Access URL: https://www.jstor.org/stable/27039797

Timing and localization of myasthenia gravis‐related gene expression

Authors: Vergoossen, Dana L. E., Keo, Arlin, Mahfouz, Ahmed, Huijbers, Maartje G.

Source: European journal of neuroscience. 54(4):5574-5585

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127413063.0x000001&indx=1&recIds=ETOCvdc_100127413063.0x000001

Sheathless CE‐MS as a tool for monitoring exchange efficiency and stability of bispecific antibodies

Authors: Gstöttner, Christoph, Vergoossen, Dana L. E., Wuhrer, Manfred, Huijbers, Maartje G. M., Domínguez‐Vega, Elena

Source: Electrophoresis. 42(1-2):171-176

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114732975.0x000001&indx=1&recIds=ETOCvdc_100114732975.0x000001

MuSK antibodies, lessons learned from poly- and monoclonality

Authors: Vergoossen, Dana L.E., Augustinus, Roy, Huijbers, Maartje G.

Source: In Journal of Autoimmunity August 2020 112

Efgartigimod improves muscle weakness in a mouse model for muscle-specific kinase myasthenia gravis

Authors: Huijbers, Maartje G., Plomp, Jaap J., van Es, Inge E., Fillié-Grijpma, Yvonne E., Kamar-Al Majidi, Samar, Ulrichts, Peter, de Haard, Hans, Hofman, Erik, van der Maarel, Silvère M., Verschuuren, Jan J.

Source: In Experimental Neurology July 2019 317:133-143

Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.

Authors: Oury, Julien, Gamallo-Lana, Begona, Santana, Leah, Steyaert, Christophe, Vergoossen, Dana L. E., Mar, Adam C., Vankerckhoven, Bernhardt, Silence, Karen, Vanhauwaert, Roeland, Huijbers, Maartje G., Burden, Steven J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/24/2024, Vol. 121 Issue 39, p1-9, 12p

Subject Terms: MYASTHENIA gravis, NEUROMUSCULAR diseases, RECOMBINANT antibodies, MUSCLE weakness, CHOLINERGIC receptors

ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome.

Authors: Vanhauwaert, Roeland, Oury, Julien, Vankerckhoven, Bernhardt, Steyaert, Christophe, Jensen, Stine Marie, Vergoossen, Dana L. E., Kneip, Christa, Santana, Leah, Lim, Jamie L., Plomp, Jaap J., Augustinus, Roy, Koide, Shohei, Blanchetot, Christophe, Ulrichts, Peter, Huijbers, Maartje G., Silence, Karen, Burden, Steven J.

Source: Science Translational Medicine; 9/18/2024, Vol. 16 Issue 765, p1-16, 16p

Subject Terms: CONGENITAL myasthenic syndromes, NEUROMUSCULAR system physiology, NEUROMUSCULAR diseases, MUSCLE weakness, MYONEURAL junction, MYASTHENIA gravis

Enrichment of serum IgG4 in MuSK myasthenia gravis patients

Authors: Vergoossen, Dana L.E., Ruiter, Annabel M., Keene, Kevin R., Niks, Erik H., Tannemaat, Martijn R., Strijbos, Ellen, Lipka, Alexander F., van der Zijde, Els C. Jol, van Tol, Maarten J.D., Bakker, Jaap A., Wevers, Brigitte A., Westerberg, Elisabet, Borges, Lúcia S., Tong, Olivia C., Richman, David P., Illa, Isabel, Punga, Anna Rostedt, Evoli, Amelia, van der Maarel, Silvère M., Verschuuren, Jan J., Huijbers, Maartje G.

Source: JOURNAL OF NEUROIMMUNOLOGY. 373

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176367519.0x000001&indx=1&recIds=ETOCvdc_100176367519.0x000001

Change of voltage‐gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse model.

Authors: Butenko, Olena, Jensen, Stine Marie, Fillié‐Grijpma, Yvonne E., Verpalen, Robyn, Verschuuren, Jan J., van der Maarel, Silvère M., Huijbers, Maartje G., Plomp, Jaap J.

Source: European Journal of Neuroscience; Jun2024, Vol. 59 Issue 12, p3292-3308, 17p

Subject Terms: SODIUM channels, ACTION potentials, LABORATORY mice, MUSCLE weakness, ANIMAL disease models, MYASTHENIA gravis, SKELETAL muscle

IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

Authors: Koneczny, Inga, Stevens, Jo A.A., De Rosa, Anna, Huda, Saif, Huijbers, Maartje G., Saxena, Abhishek, Maestri, Michelangelo, Lazaridis, Konstantinos, Zisimopoulou, Paraskevi, Tzartos, Socrates, Verschuuren, Jan, van der Maarel, Silvère M., van Damme, Philip, De Baets, Marc H., Molenaar, Peter C., Vincent, Angela, Ricciardi, Roberta, Martinez-Martinez, Pilar, Losen, Mario

Source: In Journal of Autoimmunity February 2017 77:104-115

Chapter 17 - Myasthenia gravis—Pathophysiology, diagnosis, and treatment

Authors: Tannemaat, Martijn R., Huijbers, Maartje G., Verschuuren, Jan J.G.M.

Source: In Handbook of Clinical Neurology 2024 200:283-305

Myasthenia gravis with muscle specific kinase antibodies mimicking amyotrophic lateral sclerosis

Authors: Huijbers, Maartje G. ^*, Niks, Erik H., Klooster, Rinse, de Visser, Marianne, Kuks, Jan B., Veldink, Jan H., Klarenbeek, Pim, Van Damme, Philip, de Baets, Marc H., van der Maarel, Silvère M., van den Berg, Leonard H., Verschuuren, Jan J.

Source: In Neuromuscular Disorders June 2016 26(6):350-353

Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity

Authors: Huijbers, Maartje G., Vink, Anna-Fleur D., Niks, Erik H., Westhuis, Ruben H., van Zwet, Erik W., de Meel, Robert H., Rojas-García, Ricardo, Díaz-Manera, Jordi, Kuks, Jan B., Klooster, Rinse, Straasheijm, Kirsten, Evoli, Amelia, Illa, Isabel, van der Maarel, Silvère M., Verschuuren, Jan J.

Source: In Journal of Neuroimmunology 15 February 2016 291:82-88

A prospective, placebo controlled study on the humoral immune response to and safety of tetanus revaccination in myasthenia gravis

Authors: Strijbos, Ellen, Huijbers, Maartje G., van Es, Inge E., Alleman, Iris, van Ostaijen-ten Dam, Monique M., Bakker, Jaap, van Zwet, Erik W., Jol-van der Zijde, Cornelia M., van Tol, Maarten D., Verschuuren, Jan J.

Source: Vaccine. 35(46):6290-6296

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131234295.0x000001&indx=1&recIds=ETOCvdc_100131234295.0x000001

Cortactin autoantibodies in myasthenia gravis

Authors: Gallardo, Eduard, Martínez-Hernández, Eugenia, Titulaer, Maarten J., Huijbers, Maartje G., Martínez, Maria Angeles, Ramos, Alba, Querol, Luis, Díaz-Manera, Jordi, Rojas-García, Ricard, Hayworth, Christopher R., Verschuuren, Jan J., Balice-Gordon, Rita, Dalmau, Josep, Illa, Isabel

Source: In Autoimmunity Reviews October 2014 13(10):1003-1007

Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4

Authors: Verschuuren, Jan J.G.M., Huijbers, Maartje G., Plomp, Jaap J., Niks, Erik H., Molenaar, Peter C., Martinez-Martinez, Pilar, Gomez, Alejandro M., De Baets, Marc H., Losen, Mario

Source: In Autoimmunity Reviews July 2013 12(9):918-923