Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

Authors: Hudson W Coates, Isabelle M Capell-Hattam, Ellen M Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L Byrne, Andrew J Brown

Source: eLife, Vol 12 (2023)

Subject Terms: Squalene monooxygenase, Cholesterol, Hypoxia, proteasome, protein degradation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/82843; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/3f53fc512fcc4b44b302c034457a3da2

The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

Authors: Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown

Source: Journal of Lipid Research, Vol 63, Iss 12, Pp 100295- (2022)

Subject Terms: cholesterol, cholesterol biosynthesis, cholesterol metabolism, nuclear receptors/SREBP, lipid biochemistry, molecular biology, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227522001286; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/ed19bf38775a4237b40c5078c46e0707

A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase1

Authors: Hudson W. Coates, Andrew J. Brown

Source: Journal of Lipid Research, Vol 60, Iss 10, Pp 1643-1645 (2019)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322999; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/ba415dfaa0b947b8b92eeb88e4531c14