Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

Authors: You, Eunae, Danaher, Patrick, Lu, Chenyue, Sun, Siyu, Zou, Luli, Phillips, Ildiko E., Rojas, Alexandra S., Ho, Natalie I., Song, Yuhui, Raabe, Michael J., Xu, Katherine H., Richieri, Peter M., Li, Hao, Aston, Natalie, Porter, Rebecca L., Patel, Bidish K., Nieman, Linda T., Schurman, Nathan, Hudson, Briana M., North, Khrystyna, Church, Sarah E., Deshpande, Vikram, Liss, Andrew S., Kim, Tae K., Cui, Yi, Kim, Youngmi, Greenbaum, Benjamin D., Aryee, Martin J., Ting, David T.

Source: In Cell 12 December 2024 187(25):7232-7247

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.

Authors: Park, Jiwoon, Overbey, Eliah G., Narayanan, S. Anand, Kim, JangKeun, Tierney, Braden T., Damle, Namita, Najjar, Deena, Ryon, Krista A., Proszynski, Jacqueline, Kleinman, Ashley, Hirschberg, Jeremy Wain, MacKay, Matthew, Afshin, Evan E., Granstein, Richard, Gurvitch, Justin, Hudson, Briana M., Rininger, Aric, Mullane, Sean, Church, Sarah E., Meydan, Cem

Source: Nature Communications; 6/11/2024, Vol. 15 Issue 1, p1-14, 14p

Subject Terms: MULTIOMICS, ASTRONAUTS, RAS oncogenes, INFLAMMATION, SPACE flight, EXANTHEMA, SKIN biopsy, METAGENOMICS

Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.

Authors: Nerviani, Alessandra, Boutet, Marie-Astrid, Ghirardi, Giulia Maria, Goldmann, Katriona, Sciacca, Elisabetta, Rivellese, Felice, Pontarini, Elena, Prediletto, Edoardo, Abatecola, Federico, Caliste, Mattia, Pagani, Sara, Mauro, Daniele, Bellan, Mattia, Cubuk, Cankut, Lau, Rachel, Church, Sarah E., Hudson, Briana M., Humby, Frances, Bombardieri, Michele, Lewis, Myles J.

Source: Nature Communications; 3/16/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: RHEUMATOID arthritis, INTERLEUKIN-6, SYNOVIAL fluid, DISEASE progression, THERAPEUTICS

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Authors: Overbey, Eliah G., Kim, JangKeun, Tierney, Braden T., Park, Jiwoon, Houerbi, Nadia, Lucaci, Alexander G., Garcia Medina, Sebastian, Damle, Namita, Najjar, Deena, Grigorev, Kirill, Afshin, Evan E., Ryon, Krista A., Sienkiewicz, Karolina, Patras, Laura, Klotz, Remi, Ortiz, Veronica, MacKay, Matthew, Schweickart, Annalise, Chin, Christopher R., Sierra, Maria A., Valenzuela, Matias F., Dantas, Ezequiel, Nelson, Theodore M., Cekanaviciute, Egle, Deards, Gabriel, Foox, Jonathan, Narayanan, S. Anand, Schmidt, Caleb M., Schmidt, Michael A., Schmidt, Julian C., Mullane, Sean, Tigchelaar, Seth Stravers, Levitte, Steven, Westover, Craig, Bhattacharya, Chandrima, Lucotti, Serena, Wain Hirschberg, Jeremy, Proszynski, Jacqueline, Burke, Marissa, Kleinman, Ashley S., Butler, Daniel J., Loy, Conor, Mzava, Omary, Lenz, Joan, Paul, Doru, Mozsary, Christopher, Sanders, Lauren M., Taylor, Lynn E., Patel, Chintan O., Khan, Sharib A., Suhail Mohamad, Mir, Byhaqui, Syed Gufran Ahmad, Aslam, Burhan, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan W., Siddiqui, Asim, Hornburg, Daniel, Blease, Kelly, Moreno, Juan, Boddicker, Andrew, Zhao, Junhua, Lajoie, Bryan, Scott, Ryan T., Gilbert, Rachel R., Lai Polo, San-huei, Altomare, Andrew, Kruglyak, Semyon, Levy, Shawn, Ariyapala, Ishara, Beer, Joanne, Zhang, Bingqing, Hudson, Briana M., Rininger, Aric, Church, Sarah E., Beheshti, Afshin, Church, George M., Smith, Scott M., Crucian, Brian E., Zwart, Sara R., Matei, Irina, Lyden, David C., Garrett-Bakelman, Francine, Krumsiek, Jan, Chen, Qiuying, Miller, Dawson, Shuga, Joe, Williams, Stephen, Nemec, Corey, Trudel, Guy, Pelchat, Martin, Laneuville, Odette, De Vlaminck, Iwijn, Gross, Steven, Bolton, Kelly L., Bailey, Susan M., Granstein, Richard, Furman, David, Melnick, Ari M., Costes, Sylvain V., Shirah, Bader, Yu, Min, Menon, Anil S., Mateus, Jaime, Meydan, Cem, Mason, Christopher E.

Source: Nature; 20240101, Issue: Preprints p1-10, 10p

The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling.

Authors: Schlam, Ilana, Church, Sarah E., Hether, Tyler D., Chaldekas, Krysta, Hudson, Briana M., White, Andrew M., Maisonet, Emily, Harris, Brent T., Swain, Sandra M.

Source: Journal of Translational Medicine; 11/27/2021, Vol. 19 Issue 1, p1-14, 14p

Subject Terms: GENE expression profiling, BRCA genes, BREAST, HER2 positive breast cancer, TUMOR microenvironment, GENE expression, EPIDERMAL growth factor receptors, RESEARCH, RESEARCH methodology, CANCER relapse, CELL receptors, CELL physiology, MEDICAL cooperation, EVALUATION research, PROTEOMICS, COMPARATIVE studies, BREAST tumors

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

Authors: Rivellese, Felice, Surace, Anna E. A., Goldmann, Katriona, Sciacca, Elisabetta, Çubuk, Cankut, Giorli, Giovanni, John, Christopher R., Nerviani, Alessandra, Fossati-Jimack, Liliane, Thorborn, Georgina, Ahmed, Manzoor, Prediletto, Edoardo, Church, Sarah E., Hudson, Briana M., Warren, Sarah E., McKeigue, Paul M., Humby, Frances, Bombardieri, Michele, Barnes, Michael R., Lewis, Myles J., Pitzalis, Costantino

Source: Nature Medicine; 20220101, Issue: Preprints p1-13, 13p