Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection

Authors: Huckestein, Brydie R., Zeng, Kelly, Westcott, Rosemary, Alder, Jonathan K., Antos, Danielle, Kolls, Jay K., Alcorn, John F.

Source: In The American Journal of Pathology March 2024 194(3):384-401

Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection

Authors: Cipolla, Ellyse M., Yue, Molin, Nickolich, Kara L., Huckestein, Brydie R., Antos, Danielle, Chen, Wei, Alcorn, John F.

Source: Journal of immunology. 209(4):760-771

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629944138&indx=1&recIds=ETOCRN629944138

Empagliflozin restores cardiac metabolic flexibility in diet-induced obese C57BL6/J mice

Authors: Xie, Bingxian, Ramirez, Wesley, Mills, Amanda M., Huckestein, Brydie R., Anderson, Moira, Pangburn, Martha M., Lang, Eric Y., Mullet, Steven J., Chuan, Byron W., Guo, Lanping, Sipula, Ian, O'Donnell, Christopher P., Wendell, Stacy G., Scott, Iain, Jurczak, Michael J.

Source: In Current Research in Physiology 2022 5:232-239

Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy

Authors: Bhattacharjee, Amrita, Burr, Ansen H.P., Overacre-Delgoffe, Abigail E., Tometich, Justin T., Yang, Deyi, Huckestein, Brydie R., Linehan, Jonathan L., Spencer, Sean P., Hall, Jason A., Harrison, Oliver J., Morais da Fonseca, Denise, Norton, Elizabeth B., Belkaid, Yasmine, Hand, Timothy W.

Source: In Immunity 10 August 2021 54(8):1745-1757

Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

Authors: Edmunds, Lia R., Xie, Bingxian, Mills, Amanda M., Huckestein, Brydie R., Undamatla, Ramya, Murali, Anjana, Pangburn, Martha M., Martin, James, Sipula, Ian, Kaufman, Brett A., Scott, Iain, Jurczak, Michael J.

Source: In Molecular Metabolism November 2020 41

Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice.

Authors: Huckestein, Brydie R.^1,2 (AUTHOR), Antos, Danielle^1,2 (AUTHOR), Manni, Michelle L.¹ (AUTHOR), Zeng, Kelly¹ (AUTHOR), Miller, Leigh M.^1,2 (AUTHOR), Parenteau, Kristen L.¹ (AUTHOR), Gelhaus, Stacy L.³ (AUTHOR), Mullett, Steven J.³ (AUTHOR), Shoemaker, Jason E.⁴ (AUTHOR), Alcorn, John F.^1,2 (AUTHOR) john.alcorn@chp.edu

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology. Aug2024, Vol. 327 Issue 2, pL189-L202. 14p.

Subject Terms: *REGULATORY T cells, *PNEUMONIA, *SYMPTOMS, *ANIMAL young, *LUNGS

Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Authors: Edmunds, Lia R., Huckestein, Brydie R., Kahn, Mario, Zhang, Dongyan, Chu, Yanxia, Zhang, Yingze, Wendell, Stacy G., Shulman, Gerald I., Jurczak, Michael J.

Source: Physiological reports. 7(21)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093732075.0x000001&indx=1&recIds=ETOCvdc_100093732075.0x000001

Adropin reduces blood glucose levels in mice by limiting hepatic glucose production

Authors: Thapa, Dharendra, Xie, Bingxian, Manning, Janet R., Zhang, Manling, Stoner, Michael W., Huckestein, Brydie R., Edmunds, Lia R., Zhang, Xueyang, Dedousis, Nikolaos L., O'Doherty, Robert M., Jurczak, Michael J., Scott, Iain

Source: Physiological reports. 7(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084511921.0x000001&indx=1&recIds=ETOCvdc_100084511921.0x000001

IFNγ-induction of TH1-like regulatory T cells controls antiviral responses

Authors: Gocher-Demske, Angela M., Cui, Jian, Szymczak-Workman, Andrea L., Vignali, Kate M., Latini, Julianna N., Pieklo, Gwen P., Kimball, Jesse C., Avery, Lyndsay, Cipolla, Ellyse M., Huckestein, Brydie R., Hedden, Lee, Meisel, Marlies, Alcorn, John F., Kane, Lawrence P., Workman, Creg J., Vignali, Dario A. A.

Source: Nature Immunology; May 2023, Vol. 24 Issue: 5 p841-854, 14p

Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice

Authors: Thapa, Dharendra, Xie, Bingxian, Zhang, Manling, Stoner, Michael W., Manning, Janet R., Huckestein, Brydie R., Edmunds, Lia R., Mullett, Steven J., McTiernan, Charles F., Wendell, Stacy G., Jurczak, Michael J., Scott, Iain

Source: In Journal of Molecular and Cellular Cardiology April 2019 129:174-178

Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism.

Authors: Huckestein, Brydie R., Alcorn, John F.

Source: American Journal of Respiratory Cell & Molecular Biology; Jun2022, Vol. 66 Issue 6, p598-600, 3p

Subject Terms: MITOCHONDRIA, METABOLISM, MOLECULAR volume

A Fbxo48 inhibitor prevents pAMPKa degradation and ameliorates insulin resistance

Authors: Liu, Yuan, Jurczak, Michael J., Lear, Travis B., Lin, Bo, Larsen, Mads B., Kennerdell, Jason R., Chen, Yanwen, Huckestein, Brydie R., Nguyen, Matthew K., Tuncer, Ferhan, Jiang, Yu, Monga, Satdarshan P., O’Donnell, Christopher P., Finkel, Toren, Chen, Bill B., Mallampalli, Rama K.

Source: Nature Chemical Biology; March 2021, Vol. 17 Issue: 3 p298-306, 9p

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.

Authors: Harmon, Daniel B., Mandler, W. Kyle, Sipula, Ian J., Dedousis, Nikolaos, Lewis, Sara E., Eckels, Jeremy T., Jianhai Du, Yekai Wang, Huckestein, Brydie R., Pagano, Patrick J., Cifuentes-Pagano, Eugenia, Homanics, Gregg E., Van’t Erve, Thomas J., Stefanovic-Racic, Maja, Jurczak, Michael J., O’Doherty, Robert M., Kelley, Eric E.

Source: Diabetes; Jun2019, Vol. 68 Issue 6, p1221-1229, 9p

Subject Terms: XANTHINE, URIC acid, TYPE 2 diabetes, URATES, HYPERURICEMIA, INSULIN resistance, MICE

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Influenza sequelae: from immune modulation to persistent alveolitis.

Authors: Cipolla, Ellyse M.¹, Huckestein, Brydie R.¹, Alcorn, John F.¹ john.alcorn@chp.edu

Source: Clinical Science. Jul2020, Vol. 134 Issue 13, p1697-1714. 18p.

Subject Terms: *IMMUNOREGULATION, *INFLUENZA, *DISEASE complications, *VIRUS diseases, *IMMUNOLOGIC memory, *PSYCHONEUROIMMUNOLOGY

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