Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel ROS1 fusion gene and PBX1 as prognostic marker

Authors: Patrick S. Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern, Oscar Velazquez Camacho, Christoph Jonas, Christina Alidousty, Britta Wagner, Stephanie Roessler, Thomas Albrecht, Jessica Becker, Vanessa Richartz, Barbara Holz, Sascha Hoppe, Huay Mei Poh, Burton Kuan Hui Chia, Cheryl Xueli Chan, Thushangi Pathiraja, Audrey SM Teo, Jens U. Marquardt, Alexis Khng, Michael Heise, Yao Fei, René Thieme, Sebastian Klein, Jing Han Hong, Simona O Dima, Irinel Popescu, Maria Hoppe‐Lotichius, Reinhard Buettner, Anja Lautem, Gerd Otto, Alexander Quaas, Niranjan Nagarajan, Steve Rozen, Bin Tean Teh, Benjamin Goeppert, Uta Drebber, Hauke Lang, Patrick Tan, Ines Gockel, Johannes Schumacher, Axel M. Hillmer

Source: Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)

Subject Terms: fusion genes, genomics, intrahepatic cholangiocarcinoma, PBX1, transcriptomics, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/26260a111e4f40929c73d9cf914a4148

Experimental and bioinformatics considerations in cancer application of single cell genomics

Authors: Joanna Hui Juan Tan, Say Li Kong, Joyce A. Tai, Huay Mei Poh, Fei Yao, Yee Yen Sia, Edwin Kok Hao Lim, Angela Maria Takano, Daniel Shao-Weng Tan, Asif Javed, Axel M. Hillmer

Source: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 343-354 (2021)

Subject Terms: Single cell genomics, Whole genome amplification, Single cell somatic variant caller, Protocol aware bioinformatics, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037020305468; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/19ec162017024374b03cd375a1fa8903

Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Authors: Say Li Kong, Xingliang Liu, Swee Jin Tan, Joyce A. Tai, Ler Yee Phua, Huay Mei Poh, Trifanny Yeo, Yong Wei Chua, Yu Xuan Haw, Wen Huan Ling, Raymond Chee Hui Ng, Tira J. Tan, Kiley Wei Jen Loh, Daniel Shao-Weng Tan, Quan Sing Ng, Mei Kim Ang, Chee Keong Toh, Yi Fang Lee, Chwee Teck Lim, Tony Kiat Hon Lim, Axel M. Hillmer, Yoon Sim Yap, Wan-Teck Lim

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: circulating tumor cells, cell-free tumor DNA, amplicon-sequencing, metastatic signatures, genomic heterogeneity, evolving alterations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.698551/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b70ad78864ef47c3b413d596470674f7

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

Authors: Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J. Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P. T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S. M. Teo, Cheryl X. Chan, Huay Mei Poh, Ivan M. L. Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Axel M. Hillmer, Daniel S. W. Tan

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b

Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity

Authors: Fei Yao, Jaya P. Kausalya, Yee Yen Sia, Audrey S.M. Teo, Wah Heng Lee, Alicia G.M. Ong, Zhenshui Zhang, Joanna H.J. Tan, Guoliang Li, Denis Bertrand, Xingliang Liu, Huay Mei Poh, Peiyong Guan, Feng Zhu, Thushangi Nadeera Pathiraja, Pramila N. Ariyaratne, Jaideepraj Rao, Xing Yi Woo, Shaojiang Cai, Fabianus H. Mulawadi, Wan Ting Poh, Lavanya Veeravalli, Chee Seng Chan, Seong Soo Lim, See Ting Leong, Say Chuan Neo, Poh Sum D. Choi, Elaine G.Y. Chew, Niranjan Nagarajan, Pierre-Étienne Jacques, Jimmy B.Y. So, Xiaoan Ruan, Khay Guan Yeoh, Patrick Tan, Wing-Kin Sung, Walter Hunziker, Yijun Ruan, Axel M. Hillmer

Source: Cell Reports, Vol 12, Iss 2, Pp 272-285 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112471500618X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/02de0f8a47244f94862edfad662693ff

Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks

Authors: Kuljeet Singh Sandhu, Guoliang Li, Huay Mei Poh, Yu Ling Kelly Quek, Yee Yen Sia, Su Qin Peh, Fabianus Hendriyan Mulawadi, Joanne Lim, Mile Sikic, Francesca Menghi, Anbupalam Thalamuthu, Wing Kin Sung, Xiaoan Ruan, Melissa Jane Fullwood, Edison Liu, Peter Csermely, Yijun Ruan

Source: Cell Reports, Vol 2, Iss 5, Pp 1207-1219 (2012)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124712003269; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e2f6cc497d14497286a90fc278c66109

High resolution mapping of enhancer-promoter interactions.

Authors: Christopher Reeder, Michael Closser, Huay Mei Poh, Kuljeet Sandhu, Hynek Wichterle, David Gifford

Source: PLoS ONE, Vol 10, Iss 5, p e0122420 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4430501?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ef13d032b2ac40989ff7cb29247d79cc

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.

Authors: Takashi Maejima, Tsuyoshi Inoue, Yasuharu Kanki, Takahide Kohro, Guoliang Li, Yoshihiro Ohta, Hiroshi Kimura, Mika Kobayashi, Akashi Taguchi, Shuichi Tsutsumi, Hiroko Iwanari, Shogo Yamamoto, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Huay Mei Poh, Kazuki Yamamoto, Takeshi Kawamura, Imari Mimura, Jun-ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Haruki Shibata, Yasunobu Yoshinaka, Takeshi Doi, Akimune Asanuma, Sohei Tanabe, Toshiya Tanaka, Takashi Minami, Takao Hamakubo, Juro Sakai, Naohito Nozaki, Hiroyuki Aburatani, Masaomi Nangaku, Xiaoan Ruan, Hideyuki Tanabe, Yijun Ruan, Sigeo Ihara, Akira Endo, Tatsuhiko Kodama, Youichiro Wada

Source: PLoS ONE, Vol 9, Iss 5, p e96005 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096005&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/980738f3096b45cab03bd5e5e3c87937

Chromatin Interaction Analysis with Paired-End Tag Sequencing (ChIA-PET) for Mapping Chromatin Interactions and Understanding Transcription Regulation

Authors: Yufen Goh, author¹, Melissa J. Fullwood, author^{1, 2, 3}, Huay Mei Poh, author¹, Su Qin Peh, author¹, Chin Thing Ong, author¹, Jingyao Zhang, author¹, Xiaoan Ruan, author¹, Yijun Ruan, author^{1, 3}

Source: Journal of Visualized Experiments. (62)

Availability: http://www.jove.com/video/3770

Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures.

Authors: Say Li Kong, Huipeng Li, Tai, Joyce A., Courtois, Elise T., Huay Mei Poh, Dawn Pingxi Lau, Yu Xuan Haw, Iyer, Narayanan Gopalakrishna, Shao Weng Tan, Daniel, Prabhakar, Shyam, Ruff, Dave, Hillmer, Axel M.

Source: Clinical Chemistry; Feb2019, Vol. 65 Issue 2, p272-281, 10p, 1 Chart, 4 Graphs

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multiregion exome sequencing.

Authors: Nahar, Rahul, Khng, Alexis J., Yin Yeng Lee, Xingliang Liu, Teo, Audrey S. M., Chan, Cheryl X., Huay Mei Poh, Hillmer, Axel M., Chee Keong Toh, Wan-Teck Lim, Eng-Huat Tan, Dawn Ping Xi Lau, Xue Lin Kwang, Tong Zhang, Weiwei Zhai, Angela Takano, Tony Kiat Hon Lim, Chong Hee Lim, Koh, Tina P. T., Zaw Win Aung

Source: Nature Communications; 1/15/2018, Vol. 9 Issue 1, p1-11, 11p

Subject Terms: GENOMICS, EPIDERMAL growth factor, LUNG cancer, ADENOCARCINOMA, EXOMES, NUCLEOTIDE sequencing

Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.

Authors: Tsuyoshi Inoue, Takahide Kohro, Toshiya Tanaka, Yasuharu Kanki, Guoliang Li, Huay-Mei Poh, Imari Mimura, Mika Kobayashi, Akashi Taguchi, Takashi Maejima, Jun-ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Hirofumi Aruga, Shoulian Dong, Stevens, Junko F., Shogo Yamamoto, Shuichi Tsutsumi, Toshiro Fujita, Xiaoan Ruan

Source: Genome Biology; 2014, Vol. 15 Issue 4, p1-33, 33p

The Arabidopsis ARGOS-LIKE gene regulates cell expansion during organ growth.

Authors: Yuxin Hu^1,2, Huay Mei Poh¹, Nam-Hai Chua³ chua@mail.rockefeller.edu

Source: Plant Journal. Jul2006, Vol. 47 Issue 1, p1-9. 9p. 2 Color Photographs, 2 Black and White Photographs, 3 Graphs.

Subject Terms: *CELL division, *PLANT development, *MORPHOGENESIS, *ARABIDOPSIS, *PLANT cell development, *BRASSINOSTEROIDS, *PLANT hormones