Challenges in Variable Importance Ranking Under Correlation

Authors: Liang, Annie, Jemielita, Thomas, Liaw, Andy, Svetnik, Vladimir, Huang, Lingkang, Baumgartner, Richard, Klusowski, Jason M.

Subject Terms: Statistics - Machine Learning, Computer Science - Machine Learning, Statistics - Methodology

Access URL: http://arxiv.org/abs/2402.03447

CAPITAL: Optimal Subgroup Identification via Constrained Policy Tree Search

Authors: Cai, Hengrui, Lu, Wenbin, West, Rachel Marceau, Mehrotra, Devan V., Huang, Lingkang

Subject Terms: Statistics - Machine Learning, Computer Science - Machine Learning, Statistics - Applications, Statistics - Methodology

Access URL: http://arxiv.org/abs/2110.05636

Biomarkers predictive of response to pembrolizumab in head and neck cancer

Authors: Pfister, David G., Haddad, Robert I., Worden, Francis P., Weiss, Jared, Mehra, Ranee, Chow, Laura Q. M., Liu, Stephen V., Kang, Hyunseok, Saba, Nabil F., Wirth, Lori J., Sukari, Ammar, Massarelli, Erminia, Ayers, Mark, Albright, Andrew, Webber, Andrea L., Mogg, Robin, Lunceford, Jared, Huang, Lingkang, Cristescu, Razvan, Cheng, Jonathan, Seiwert, Tanguy Y., Bauml, Joshua M.

Source: Cancer medicine. 12(6):6603-6614

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185281798.0x000001&indx=1&recIds=ETOCvdc_100185281798.0x000001

CAPITAL: Optimal subgroup identification via constrained policy tree search

Authors: Cai, Hengrui, Lu, Wenbin, Marceau West, Rachel, Mehrotra, Devan V., Huang, Lingkang

Source: Statistics in medicine. 41(21):4227-4244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159003744.0x000001&indx=1&recIds=ETOCvdc_100159003744.0x000001

Molecular determinants of response to neoadjuvant pembrolizumab plus chemotherapy in patients with high-risk, early-stage, triple-negative breast cancer: exploratory analysis of the open-label, multicohort phase 1b KEYNOTE-173 study.

Authors: Dent, Rebecca, Cortés, Javier, Park, Yeon Hee, Muñoz-Couselo, Eva, Kim, Sung-Bae, Sohn, Joohyuk, Im, Seock-Ah, Holgado, Esther, Foukakis, Theodoros, Kümmel, Sherko, Yearley, Jennifer, Wang, Anran, Nebozhyn, Michael, Huang, Lingkang, Cristescu, Razvan, Jelinic, Petar, Karantza, Vassiliki, Schmid, Peter

Source: Breast Cancer Research; 3/11/2025, Vol. 27 Issue 1, p1-12, 12p

Comparing programmed death ligand 1 scores for predicting pembrolizumab efficacy in head and neck cancer

Authors: Emancipator, Kenneth, Huang, Lingkang, Aurora-Garg, Deepti, Bal, Tricia, Cohen, Ezra E.W., Harrington, Kevin, Soulières, Denis, Le Tourneau, Christophe, Licitra, Lisa, Burtness, Barbara, Swaby, Ramona

Source: In Modern Pathology March 2021 34(3):532-541

Impact of PD-L1 and T-cell inflamed gene expression profile on survival in advanced ovarian cancer

Authors: Høgdall, Estrid ^{1, *}, Høgdall, Claus ², Vo, Thao ³, Zhou, Wei ³, Huang, Lingkang ³, Marton, Matthew ³, Keefe, Stephen M ³, Busch-Sørensen, Michael ⁴, Sørensen, Sarah M. ², Georgsen, Jeanette ⁵, Mejlgaard, Else ⁵, Nedergaard, Lotte ⁶, Steiniche, Torben ⁵

Source: In International Journal of Gynecological Cancer July 2020 30(7):1034-1042

Equivalence of laboratory-developed test and PD-L1 IHC 22C3 pharmDx across all combined positive score indications.

Authors: Vainer, Gilad¹ (AUTHOR) giladwv@gmail.com, Huang, Lingkang² (AUTHOR), Emancipator, Kenneth³ (AUTHOR), Nuti, Shanthy⁴ (AUTHOR)

Source: PLoS ONE. 6/2/2023, Vol. 18 Issue 6, p1-12. 12p.

Subject Terms: *PROGRAMMED death-ligand 1, *TRIPLE-negative breast cancer, *INTRACLASS correlation, *SQUAMOUS cell carcinoma, *TRANSITIONAL cell carcinoma

Germline HLA landscape does not predict efficacy of pembrolizumab monotherapy across solid tumor types

Authors: Chhibber, Aparna, Huang, Lingkang, Zhang, Hong, Xu, Jialin, Cristescu, Razvan, Liu, Xiaoqiao, Mehrotra, Devan V., Shen, Judong, Shaw, Peter M., Hellmann, Matthew D., Snyder, Alexandra

Source: Immunity. 55(1):56-64.e4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154170001.0x000001&indx=1&recIds=ETOCvdc_100154170001.0x000001

Contribution of tumour and immune cells to PD‐L1 expression as a predictive biomarker in metastatic triple‐negative breast cancer: exploratory analysis from KEYNOTE‐119.

Authors: Cortes, Javier, Winer, Eric P, Lipatov, Oleg, Im, Seock‐Ah, Gonçalves, Anthony, Muñoz‐Couselo, Eva, Lee, Keun Seok, Schmid, Peter, Tamura, Kenji, Testa, Laura, Witzel, Isabell, Ohtani, Shoichiro, Hund, Stephanie, Kulangara, Karina, Karantza, Vassiliki, Mejia, Jaime A, Ma, Junshui, Jelinic, Petar, Huang, Lingkang, Pruitt, Scott K

Source: Journal of Pathology: Clinical Research; May2024, Vol. 10 Issue 3, p1-10, 10p

Subject Terms: TRIPLE-negative breast cancer, PROGRAMMED death-ligand 1, BIOMARKERS, RECEIVER operating characteristic curves

Genetic analysis of asthma exacerbations

Authors: Anderson, Wayne H., Koshy, Beena T., Huang, Lingkang, Mosteller, Michael, Stinnett, Sandra W., Condreay, Lynn D., Ortega, Hector

Source: In Annals of Allergy, Asthma & Immunology June 2013 110(6):416-422

Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma

Authors: Xu, Chun-Fang, Reck, Brian H., Goodman, Vicki L., Xue, Zhengyu, Huang, Lingkang, Barnes, Michael R., Koshy, Beena, Spraggs, Colin F., Mooser, Vincent E., Cardon, Lon R., Pandite, Lini N.

Source: In Journal of Hepatology June 2011 54(6):1237-1243

Association Between Biomarkers and Clinical Outcomes of Pembrolizumab Monotherapy in Patients With Metastatic Triple-Negative Breast Cancer: KEYNOTE-086 Exploratory Analysis.

Authors: Loi, Sherene, Salgado, Roberto, Schmid, Peter, Cortes, Javier, Cescon, David W., Winer, Eric P., Toppmeyer, Deborah L., Rugo, Hope S., De Laurentiis, Michelino, Nanda, Rita, Iwata, Hiroji, Awada, Ahmad, Tan, Antoinette R., Sun, Yuan, Karantza, Vassiliki, Wang, Anran, Huang, Lingkang, Saadatpour, Assieh, Cristescu, Razvan, Yearley, Jennifer

Source: JCO Precision Oncology; 4/26/2023, Vol. 7, p1-14, 14p

Subject Terms: TRIPLE-negative breast cancer, BIOMARKERS, TREATMENT effectiveness, HEMATOXYLIN & eosin staining, GENE expression profiling

Indirect Clinical Validation of a Programmed Death-Ligand 1 Laboratory-Developed Test for Gastric/Gastroesophageal Junction Adenocarcinoma with 22C3 Antibody Concentrate.

Authors: Kim, Ji Min, Kim, Binnari, Kim, Eunji, Jang, Minsun, Cho, Jun Hun, Lee, Hye Seung, Kwak, Yoonjin, Huang, Lingkang, Krishnan, Radha, Bai, Sally Y., Mounawar, Mounia, Kim, Kyoung-Mee

Source: Molecular Diagnosis & Therapy; Nov2022, Vol. 26 Issue 6, p679-688, 10p

Subject Terms: PROGRAMMED death-ligand 1, ESOPHAGOGASTRIC junction, PROGRAMMED cell death 1 receptors, FLUORESCENT antibody technique, INTRACLASS correlation, IMMUNOGLOBULINS, ADENOCARCINOMA

Geographic Terms: ASIA

Missing Data Framework for Estimating Biomarker Clinical Utility Under Incomplete Follow-Up
Joint statistical meetings

Authors: Kobie, Julie, Huang, Lingkang, Mogg, Robin, Lunceford, Jared

Source: JSM proceedings (CD-ROM edition). 2018:122-2

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN605160199&indx=1&recIds=ETOCCN605160199

Interchangeability of PD-L1 laboratory-developed test by 22C3 antibody concentrate among ihc platforms in gastric cancer

Authors: Kim, Jimin, Kim, Binnari, Kim, Eunji, Jang, Minsun, Cho, Jun Hun, Lee, Hye Seung, Kwak, Yoonjin, Huang, Lingkang, Juco, Jonathan, Bai, Sally, Kim, Kyoung-Mee

Source: Pathology. 52(S1):S120-S120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118761985.0x000001&indx=1&recIds=ETOCvdc_100118761985.0x000001

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

Authors: Zeng Zhao-Bang, Heinloth Alexandra N, Huang Lingkang, Paules Richard S, Bushel Pierre R

Source: BMC Genomics, Vol 9, Iss 1, p 288 (2008)

Subject Terms: Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2164/9/288; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/5f7ee1fbb25a4673b44bcb054c0a310d

Pan-tumour analysis of the association between PD-L1 combined positive score (CPS) and response to pembrolizumab monotherapy

Authors: Huang, Lingkang, Lunceford, Jared, Ma, Junshui, Emancipator, Kenneth

Source: In Pathology July 2021 53 Supplement 1:S48-S48

Contribution of tumour and immune cells to PD-L1 as a predictive biomarker in metastatic triple-negative breast cancer (mTNBC): analysis from keynote-119

Authors: Emancipator, Kenneth, Winer, Eric P., Lipatov, Oleg, Im, Seock-Ah, Goncalves, Anthony, Muñoz-Couselo, Eva, Lee, Keun Seok, Nowecki, Zbigniew, Schmid, Peter, Tamura, Kenji, Testa, Laura, Witzel, Isabell, Ohtani, Shoichiro, Hund, Stephanie, Kulangara, Karina, Karantza, Vassiliki, Mejia, Jaime A., Ma, Junshui, Jelinic, Petar, Huang, Lingkang, Cortes, Javier

Source: In Pathology July 2021 53 Supplement 1:S47-S48

Analytical comparison of a PD-L1 22C3 antibody laboratory-developed test (LDT) protocol on the benchmark XT and PD-L1 IHC 22C3 pharmdx: analysis of pan-tumour and oesophageal cancer samples

Authors: Vainer, Gilad W., Zatara, Ghadeer, Huang, Lingkang, Emancipator, Kenneth, Nuti, Shanthy

Source: In Pathology July 2021 53 Supplement 1:S47-S47