Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions

Authors: Anderson, Jason T., Huang, Kevin M., Lustberg, Maryam B., Sparreboom, Alex, Hu, Shuiying

Source: Reviews of physiology, biochemistry and pharmacology. 183:177-216

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631137979&indx=1&recIds=ETOCRN631137979

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

Authors: Huang, Kevin M., Thomas, Megan Zavorka, Magdy, Tarek, Eisenmann, Eric D., Uddin, Muhammad Erfan, DiGiacomo, Duncan F., Pan, Alexander, Keiser, Markus, Otter, Marcus, Xia, Sherry H., Li, Yang, Jin, Yan, Fu, Qiang, Gibson, Alice A., Bonilla, Ingrid M., Carnes, Cynthia A., Corps, Kara N., Coppola, Vincenzo, Smith, Sakima A., Addison, Daniel, Nies, Anne T., Bundschuh, Ralf, Chen, Taosheng, Lustberg, Maryam B., Wang, Joanne, Oswald, Stefan, Campbell, Moray J., Yan, Pearlly S., Baker, Sharyn D., Hu, Shuiying, Burridge, Paul W., Sparreboom, Alex

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb 01. 118(5), 1-9.

Access URL: https://www.jstor.org/stable/27006166

Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition

Authors: Bai, Yuntao, Kim, Ji Young, Bisunke, Bijay, Jayne, Laura A., Silvaroli, Josie A., Balzer, Michael S., Gandhi, Megha, Huang, Kevin M., Sander, Veronika, Prosek, Jason, Cianciolo, Rachel E., Baker, Sharyn D., Sparreboom, Alex, Jhaveri, Kenar D., Susztak, Katalin, Bajwa, Amandeep, Pabla, Navjot Singh

Source: In Kidney International December 2021 100(6):1214-1226

Role of SLC transporters in toxicity induced by anticancer drugs

Authors: Huang, Kevin M., Uddin, Muhammad Erfan, DiGiacomo, Duncan, Lustberg, Maryam B., Hu, Shuiying, Sparreboom, Alex

Source: Expert opinion on drug metabolism and toxicology. 16(6):493-506

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Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si–Wu–Tang on Nrf2 signaling and neoplastic cellular transformation

Authors: Liu, Mandy M., Huang, Kevin M., Qian, Li, Chatterjee, Payal, Zhang, Suhui, Li, Rui, Zhou, Su, Wang, Zhijun, Luo, Yun, Huang, Ying

Source: In Phytomedicine 1 February 2018 40:1-9

Development and validation of a UPLC-MS/MS analytical method for dofetilide in mouse plasma and urine, and its application to pharmacokinetic study

Authors: Uddin, Muhammad Erfan, Sun, Xinxin, Huang, Kevin M., Hu, Shuiying, Carnes, Cynthia A., Sparreboom, Alex, Fu, Qiang

Source: Journal of pharmaceutical and biomedical analysis. 172:183-188

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082181595.0x000001&indx=1&recIds=ETOCvdc_100082181595.0x000001

Drug transporters and anthracycline-induced cardiotoxicity

Authors: Huang, Kevin M, Hu, Shuiying, Sparreboom, Alex

Source: Pharmacogenomics. 19(11):883-888

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Targeting drug transporters to prevent chemotherapy-induced peripheral neuropathy

Authors: Huang, Kevin M., Hu, Shuiying

Source: Molecular & cellular oncology. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114097168.0x000001&indx=1&recIds=ETOCvdc_100114097168.0x000001

TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion.

Authors: Eisenmann, Eric D., Stromatt, Jack C., Fobare, Sydney, Huang, Kevin M., Buelow, Daelynn R., Orwick, Shelley, Jeon, Jae Yoon, Weber, Robert H., Larsen, Bill, Mims, Alice S., Hertlein, Erin, Byrd, John C., Baker, Sharyn D.

Source: Cancers; Jan2023, Vol. 15 Issue 1, p29, 14p

Subject Terms: BIOLOGICAL models, IN vitro studies, GENETIC mutation, XENOGRAFTS, DNA, IN vivo studies, PROTEIN kinase inhibitors, PHOSPHOTRANSFERASES, ANIMAL experimentation, ANTINEOPLASTIC agents, APOPTOSIS, CELL cycle proteins, CELL survival, IMMUNOBLOTTING, DECITABINE, TUMOR suppressor genes, RESEARCH funding, CELL lines, MICE, OVERALL survival, PHARMACODYNAMICS

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.

Authors: Uddin, Muhammad Erfan, Eisenmann, Eric D., Li, Yang, Huang, Kevin M., Garrison, Dominique A., Talebi, Zahra, Gibson, Alice A., Jin, Yan, Nepal, Mahesh, Bonilla, Ingrid M., Fu, Qiang, Sun, Xinxin, Millar, Alec, Tarasov, Mikhail, Jay, Christopher E., Cui, Xiaoming, Einolf, Heidi J., Pelis, Ryan M., Smith, Sakima A., Radwański, Przemysław B.

Source: International Journal of Molecular Sciences; Aug2022, Vol. 23 Issue 15, p8607-8607, 19p

Subject Terms: PROARRHYTHMIA, VENTRICULAR arrhythmia, ARRHYTHMIA, ATRIAL flutter, DRUG interactions, ATRIAL fibrillation, ORGANIC cation transporters

Role of transporters and S100A8/A9 in paclitaxel‐induced peripheral neuropathy

Authors: Li, Yang, Zavorka Thomas, Megan E., Leblanc, Alix F., Huang, Kevin M., Chen, Mingqing, Sprowl, Jason A., Gibson, Alice A., Lustburg, Maryam M., Sparreboom, Alex, Hu, Shuiying

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140403998.0x000001&indx=1&recIds=ETOCvdc_100140403998.0x000001

Differential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity

Authors: Huang, Kevin M., Leblanc, Alix F., Alberti, Paola, Sprowl, Jason A., Wang, Jing, Lustberg, Maryam B., Cavaletti, Guido, Hu, Shuiying, Sparreboom, Alex

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140400667.0x000001&indx=1&recIds=ETOCvdc_100140400667.0x000001

Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.

Authors: Huang, Kevin M.¹, Leblanc, Alix F.¹, Uddin, Muhammad Erfan¹, Ji Young Kim¹, Mingqing Chen¹, Eisenmann, Eric D.¹, Gibson, Alice A.¹, Yang Li¹, Hong, Kristen W.¹, DiGiacomo, Duncan¹, Xia, Sherry H.¹, Alberti, Paola^2,3, Chiorazzi, Alessia^2,3, Housley, Stephen N.⁴, Cope, Timothy C.⁴, Sprowl, Jason A.⁵, Jing Wang⁶, Loprinzi, Charles L.⁷, Noonan, Anne⁸, Lustberg, Maryam B.⁸

Source: Journal of Clinical Investigation. Sep2020, Vol. 130 Issue 9, p4601-4606. 6p. 4 Graphs.

Subject Terms: *ORGANIC cation transporters, *NEUROTOXICOLOGY, *SATELLITE cells, *ANIMAL models in research, *NEUROGLIA

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OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity

Authors: Leblanc, Alix F., Sprowl, Jason A., Alberti, Paola, Chiorazzi, Alessia, Arnold, W. David, Gibson, Alice A., Hong, Kristen W., Pioso, Marissa S., Chen, Mingqing, Huang, Kevin M.

Source: Journal of clinical investigation. 128(2):816-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614993674&indx=1&recIds=ETOCRN614993674

Role of SLCtransporters in toxicity induced by anticancer drugs

Authors: Huang, Kevin M., Uddin, Muhammad Erfan, DiGiacomo, Duncan, Lustberg, Maryam B., Hu, Shuiying, Sparreboom, Alex

Source: Expert Opinion on Drug Metabolism & Toxicology; June 2020, Vol. 16 Issue: 6 p493-506, 14p

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors.

Authors: Cleveland, Kristan H., Liang, Sherry, Chang, Andy, Huang, Kevin M., Chen, Si, Guo, Lei, Huang, Ying, Andresen, Bradley T.

Source: PLoS ONE; 5/20/2019, Vol. 14 Issue 5, p1-23, 23p

Subject Terms: ADRENERGIC receptors, CARVEDILOL, EPIDERMAL growth factor, CELL transformation, COCARCINOGENESIS, CELL growth

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