Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Authors: Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L. Koleske, Niklas Handin, Virginia M. Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M. Brand, Finn D. Wolfreys, Jia Yang, Jason E. Gestwicki, John A. Capra, Per Artursson, John W. Newman, Tomàs Marquès-Bonet, Kathleen M. Giacomini

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a48ee6cda4514840ac818713e505c1b2

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

Authors: Sook Wah Yee, Adrian Stecula, Huan-Chieh Chien, Ling Zou, Elena V Feofanova, Marjolein van Borselen, Kit Wun Kathy Cheung, Noha A Yousri, Karsten Suhre, Jason M Kinchen, Eric Boerwinkle, Roshanak Irannejad, Bing Yu, Kathleen M Giacomini

Source: PLoS Genetics, Vol 15, Iss 9, p e1008208 (2019)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/5623312d5ce545b0ae5d208f5ebfc7e6

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

Authors: Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M Krauss, Kathleen M Giacomini

Source: PLoS Biology, Vol 16, Iss 4, p e2002907 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5919692?pdf=render; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/b0a8de10439546bea60bb2c9df501479

Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage.

Authors: Huan-Chieh Chien, Hurng-Yi Wang, Yi-Ning Su, Kuan-Yu Lai, Li-Chen Lu, Pau-Chung Chen, Shih-Feng Tsai, Chung-I Wu, Wu-Shiun Hsieh, Che-Kun James Shen

Source: PLoS ONE, Vol 7, Iss 10, p e47481 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3468564?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/303ba22ccc3640d89ee3db304f3c0e65

Rate of evolution in brain-expressed genes in humans and other primates.

Authors: Hurng-Yi Wang, Huan-Chieh Chien, Naoki Osada, Katsuyuki Hashimoto, Sumio Sugano, Takashi Gojobori, Chen-Kung Chou, Shih-Feng Tsai, Chung-I Wu, C-K James Shen

Source: PLoS Biology, Vol 5, Iss 2, p e13 (2007)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/33f9b05f0c024c3b89a38d87fdb7cb12

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.

Authors: Ling Zou, Spanogiannopoulos, Peter, Pieper, Lindsey M., Huan-Chieh Chien, Wenlong Cai, Khuri, Natalia, Pottel, Joshua, Vora, Bianca, Zhanglin Ni, Tsakalozou, Eleftheria, Wenjun Zhang, Shoichet, Brian K., Giacomini, Kathleen M., Turnbaugh, Peter J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/7/2020, Vol. 117 Issue 27, p16009-16018, 10p

Subject Terms: DRUG absorption, DRUG additives, FOOD additives, BACTERIAL metabolism, INTESTINAL absorption

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).

Authors: Chen, Eugene C., Khuri, Natalia, Xiaomin Liang, Stecula, Adrian, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Sali, Andrej, Giacomini, Kathleen M.

Source: Journal of Medicinal Chemistry; 4/13/2017, Vol. 60 Issue 7, p2685-2696, 12p

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.

Authors: Peng Yang¹, Yixuan Wang^1,2, Don Hoang¹, Tinkham, Matthew¹, Patel, Anamika³, Ming-An Sun¹, Wolf, Gernot¹, Baker, Mairead¹, Huan-Chieh Chien^4,5, Kuan-Yu Nick Lai^4,5, Xiaodong Cheng³, Che-Kun James Shen^4,5, ckshen@gate.sinica.edu.tw, Macfarlan, Todd S.¹, todd.macfarlan@nih.gov

Source: Science; 5/19/2017, Vol. 356 Issue 6339, p757-759, 3p, 1 Color Photograph, 3 Graphs

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Authors: Ligong Chen, Yan Shu, Xiaomin Liang, Chen, Eugene C., Sook Wah Yee, Zur, Arik A., Li, Shuanglian, Lu Xu, Keshari, Kayvan R., Lin, Michael J., Huan-Chieh Chien, Youcai Zhang, Morrissey, Kari M., Jason Liu, Ostrem, Jonathan, Younger, Noah S., Kurhanewicz, John, Shokat, Kevan M., Ashrafid, Kaveh, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/8/2014, Vol. 111 Issue 27, p9983-9988, 6p

Subject Terms: THIAMINE transporter proteins, FATTY degeneration, METFORMIN, LABORATORY mice, TRIGLYCERIDES