The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen, Yijuang Chern

Source: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-12 (2017)

Subject Terms: Type V adenylyl cyclase, AC6, cAMP, STAT3, Microdomain, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-017-0367-3; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/eb06859d5bc34c888bd24cfbfe88efcf

The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration

Authors: Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern

Source: Frontiers in Neuroscience, Vol 12 (2018)

Subject Terms: TDP-43, A2A adenosine receptor, D2 dopamine receptor, cAMP, PKA motor neurons, ALS, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fnins.2018.00187/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/7d5fdee80ace4492bad85262ede7ac8a

A new drug design targeting the adenosinergic system for Huntington's disease.

Authors: Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern

Source: PLoS ONE, Vol 6, Iss 6, p e20934 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3119665?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/98dd3664ced9445b93d70d9ae3a8e2cd

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Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.

Authors: Yu-Han Kao, Meng-Syuan Lin, Chiung-Mei Chen, Yih-Ru Wu, Hui-Mei Chen, Hsing-Lin Lai, Yijuang Chern, Chun-Jung Lin

Source: Human Molecular Genetics; Feb2017, Vol. 26 Issue 3, p467-478, 12p

Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.

Authors: Yu-Ju Liu, Tz-Chuen Ju, Hui-Mei Chen, Yu-Sung Jang, Li-Ming Lee, Hsing-Lin Lai, Hua-Chia Tai, Jim-Min Fang, Yun-Lian Lin, Pang-Hsien Tu, Yijuang Chern

Source: Human Molecular Genetics; Feb2015, Vol. 24 Issue 3, p787-801, 15p, 2 Diagrams, 1 Chart, 6 Graphs

Galectin-3 aggravates microglial activation and tau transmission in tauopathy.

Authors: Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, Blum, David, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo

Source: Journal of Clinical Investigation. 1/16/2024, Vol. 134 Issue 2, p1-16. 16p.

Subjects: TAUOPATHIES, AMYLOID plaque, TAU proteins, INDUCED pluripotent stem cells, GALECTINS, ALZHEIMER'S disease, MICROGLIA

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease.

Authors: Jiun-Tsai Lin, Wei-Cheng Chang, Hui-Mei Chen, Hsing-Lin Lai, Chih-Yeh Chen, Mi-Hua Tao, Yijuang Chern

Source: Molecular & Cellular Biology; Mar2013, Vol. 33 Issue 5, p1073-1084, 12p

Subject Terms: HUNTINGTON disease, NEURODEGENERATION, PROTEASOMES, CYCLIC-AMP-dependent protein kinase, PROTEIN kinases

Type VI Adenylyl Cyclase Regulates Neurite Extension by Binding to Snapin and Snap25.

Authors: Chia-Shan Wu, Jiun-Tsai Lin, Chen-Li Chien, Wei-Cheng Chang, Hsing-Lin Lai, Ching-Pang Chang, Yijuang Chern

Source: Molecular & Cellular Biology; Dec2011, Vol. 31 Issue 24, p4874-4886, 4p

Subject Terms: ADENYLATE cyclase, LYASES, BRAIN, HIPPOCAMPUS (Brain), PHOSPHORYLATION

Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes.

Authors: Szu-Yi Chou, Ju-Yun Weng, Hsing-Lin Lai, Fang Liao, Sun, Synthia H., Pang-Hsien Tu, Dickson, Dennis W., Yijuang Chern

Source: Journal of Neuroscience; 3/26/2008, Vol. 28 Issue 13, p3277-3290, 14p, 2 Diagrams, 1 Chart, 6 Graphs

Subject Terms: HUNTINGTON disease, PROTEIN-protein interactions, GLUTAMINE, CHEMOKINES, ASTROCYTES, T cells, GENETIC transcription, GENETICS

Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.

Authors: Shyi-Chyi Wang¹, Hsing-Lin Lai², Yi-Ting Chiu², Ren Ou², Chuen-Lin Huang³, Yijuang Chern¹

Source: Biochemical Journal. 2007, Vol. 406 Issue 3, p383-388. 6p.

Subject Terms: *ADENYLATE cyclase, *PROTEINS, *LYASES, *NUCLEOTIDES, *G proteins

CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

Authors: Szu-Yi Chou, Yi-Chao Lee, Hui-Mei Chen, Ming-Chang Chiang, Hsing-Lin Lai, Hao-Hung Chang, Yi-Chih Wu, Chung-Nan Sun, Chen-Li Chien, Yow-Sien Lin, Shyi-Chyi Wang, Yu-Ying Tung, Chen Chang, Yijuang Chern

Source: Journal of Neurochemistry; Apr2005, Vol. 93 Issue 2, p310-320, 11p

Subject Terms: ADENOSINES, THERAPEUTICS, PROTEIN kinases, HUNTINGTON disease, NEURODEGENERATION, NEUROCHEMISTRY

An Important Functional Role of the N Terminus Domain of Type VI Adenylyl Cyclase in Gαi-mediated Inhibition.

Authors: Yu-Ya Kao^1,2, Hsing-Lin Lai¹, Ming-Jing Hwang¹, Yijuang Chern^1,2 bmychern@ibms.sinica.edu.tw

Source: Journal of Biological Chemistry. 8/13/2004, Vol. 279 Issue 33, p34440-34448. 9p. 11 Diagrams, 1 Chart, 4 Graphs.

Subject Terms: *ADENYLATE cyclase, *FORSKOLIN, *PROTEIN binding, *BINDING sites, *BIOCHEMISTRY, *GENETIC mutation

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Regulation of Type VT Adenylyl Cyclase by Snapin, a SNAP25-binding Protein.

Authors: Jui-ling Chou^1,2,3, Chuen-lin Huang¹, Hsing-lin Lai¹, Hung, Amos C.¹, Chen-li Chien¹, Yu-ya Kao^1,2, Yijuang Chern^1,2 bmychern@ibms.sinica.edu.tw

Source: Journal of Biological Chemistry. 10/29/2004, Vol. 279 Issue 44, p46271-46279. 9p. 12 Color Photographs, 1 Diagram, 1 Chart, 6 Graphs.

Subject Terms: *CARRIER proteins, *PROTEIN binding, *PROTEINS, *ADENYLATE cyclase, *LYASES, *ENZYMES, *BRAIN, *CIRCULAR DNA