Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence.

Authors: Chen, Yi-Ming^1,2,3,4,5,6 (AUTHOR), Hsiao, Tzu-Hung^3,7,8 (AUTHOR), Lin, Ching-Heng^3,7,9,10 (AUTHOR) epid@vghtc.gov.tw, Fann, Yang C.¹¹ (AUTHOR) fann@ninds.nih.gov

Source: Journal of Biomedical Science. 2/7/2025, Vol. 32 Issue 1, p1-12. 12p.

Subject Terms: *MACHINE learning, *CLINICAL decision support systems, *INDIVIDUALIZED medicine, *ARTIFICIAL intelligence, *ELECTRONIC health records

Utilizing polygenic risk score for breast cancer risk prediction in a Taiwanese population

Authors: Lin, Yi-Hsuan ^a, Hung, Chih-Chiang ^{a, b, c}, Lin, Guan-Cheng ^d, Tsai, I.-Chen ^{a, e}, Lum, Chih Yean ^{a, ⁎}, Hsiao, Tzu-Hung ^{c, f, g, ⁎⁎}

Source: In Cancer Epidemiology February 2025 94

Genome-Wide Association Study (GWAS) on Metabolic Syndrome in Subjects with Abdominal Obesity in a Taiwanese Population

Authors: Yeh, Kuan-Hung, Lin, Ching-Heng, Hsiao, Tzu-Hung, Lu, Tzu-Pin

Source: 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2020 IEEE International Conference on. :1403-1407 Dec, 2020

Relation: 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Characteristics of Cancer in Subjects Carrying Lynch Syndrome-Associated Gene Variants in Taiwanese Population: A Hospital-Based Study in Taiwan.

Authors: Chen, Yi-Peng¹ (AUTHOR) great800700@vghtc.gov.tw, Hsiao, Tzu-Hung^2,3,4 (AUTHOR) thsiao@vghtc.gov.tw, Lin, Wan-Tzu¹ (AUTHOR) woantyy0025@vghtc.gov.tw, Liao, Yi-Jun^1,5 (AUTHOR) yjliao@vghtc.gov.tw, Liao, Szu-Chia^1,5 (AUTHOR) scarkett@vghtc.gov.tw, Tsai, Hsin-Ju^1,5 (AUTHOR) tsaihj@vghtc.gov.tw, Chen, Yen-Ju^2,6,7 (AUTHOR) aoaichen@vghtc.gov.tw, Jhan, Pei-Pei² (AUTHOR) cuepeipei@vghtc.gov.tw, Kao, Pei-Ying² (AUTHOR) peggy9456@vghtc.gov.tw, Lin, Ying-Cheng^1,5 (AUTHOR) ethankevin516@vghtc.gov.tw, Chuang, Han-Ni² (AUTHOR) ethankevin516@vghtc.gov.tw

Source: Cancers. Nov2024, Vol. 16 Issue 21, p3682. 13p.

Subject Terms: *HEREDITARY nonpolyposis colorectal cancer, *TAIWANESE people, *RISK assessment, *PUBLIC health surveillance, *BRCA genes, *RESEARCH funding, *EARLY detection of cancer, *COLORECTAL cancer, *ENDOSCOPIC surgery, *DNA, *PROSTATE tumors, *GENETIC variation, *AGE factors in disease, *COLON polyps, *COLON (Anatomy), *DNA repair, *ONCOGENES, *GENETIC mutation, *ENDOSCOPY, *GENOTYPES, *COLONOSCOPY, *GENETIC testing, *DISEASE risk factors

Geographic Terms: TAIWAN

SEAGLE: A Scalable Exact Algorithm for Large-Scale Set-Based GxE Tests in Biobank Data

Authors: Chi, Jocelyn T., Ipsen, Ilse C. F., Hsiao, Tzu-Hung, Lin, Ching-Heng, Wang, Li-San, Lee, Wan-Ping, Lu, Tzu-Pin, Tzeng, Jung-Ying

Subject Terms: Statistics - Computation, Statistics - Methodology

Access URL: http://arxiv.org/abs/2105.03228

Predicting drug response through tumor deconvolution by cancer cell lines

Authors: Hsu, Yu-Ching ^{1, 2, 3, 4}, Chiu, Yu-Chiao ^{5, 6}, Lu, Tzu-Pin ³, Hsiao, Tzu-Hung ^{7, ∗}, Chen, Yidong ^{4, 8, 9, ∗∗}

Source: In Patterns 12 April 2024 5(4)

The Prevalence and Features of Medications With Actionable Pharmacogenomic Biomarkers Prescribed to Kidney Transplant Recipients

Authors: Chang, Yen-Lin, Hsiao, Tzu-Hung, Wu, Ming-Fen, Chen, Cheng-Hsu

Source: Transplantation proceedings. 55(4):862-866

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192329631.0x000001&indx=1&recIds=ETOCvdc_100192329631.0x000001

Chemoresistance in acute myeloid leukemia: An alternative single‐cell RNA sequencing approach

Authors: Cheng, Po‐Liang, Hsiao, Tzu‐Hung, Chen, Chung‐Hsing, Hung, Miao‐Neng, Jhan, Pei‐Pei, Lee, Li‐Wen, Wu, Ting‐Shuan, Tsai, Jia‐Rung, Teng, Chieh‐Lin Jerry

Source: Hematological oncology. 41(3):499-509

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190082372.0x000001&indx=1&recIds=ETOCvdc_100190082372.0x000001

Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol‐related disorder and cancer

Authors: Chang, Ting‐Gang, Yen, Ting‐Ting, Wei, Chia‐Yi, Hsiao, Tzu‐Hung, Chen, I‐Chieh

Source: Cancer medicine. 12(1):747-759

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187841413.0x000001&indx=1&recIds=ETOCvdc_100187841413.0x000001

Perinatal lethal Gaucher disease due to compound heterozygosity of the splicing mutations in GBA gene

Authors: Lu, Tsai-Jung, Hsiao, Tzu-Hung, Wang, Jiaan-Der, Lo, Feng-Chu, Jhan, Pei-Pei, Chen, Wei-Chih

Source: Taiwanese journal of obstetrics & gynecology. 62(1):175-178

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180186647.0x000001&indx=1&recIds=ETOCvdc_100180186647.0x000001

Genetic variations in bitter and sweet taste receptors in Taiwanese patients with chronic rhinosinusitis

Authors: Jiang, Rong‐San, Lin, Hsueh‐Ju, Wei, Chia‐Yi, Hsiao, Tzu‐Hung

Source: International forum of allergy & rhinology. 13(3):265-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175751450.0x000001&indx=1&recIds=ETOCvdc_100175751450.0x000001

Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data

Authors: Chattopadhyay, Amrita, Lee, Chien-Yueh, Shen, Ying-Cheng, Lu, Kuan-Chen, Hsiao, Tzu-Hung, Lin, Ching-Heng, Lai, Liang-Chuan, Tsai, Mong-Hsun, Lu, Tzu-Pin, Chuang, Eric Y.

Source: In Journal of Biomedical Informatics July 2023 143

Analyzing differential regulatory networks modulated by continuous-state genomic features in glioblastoma multiforme

Authors: Chiu, Yu-Chiao, Kai-Wen Liang, Hsiao, Tzu-Hung, Chen, Yidong, Chuang, Eric Y.

Source: 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2015 IEEE International Conference on. :171-176 Nov, 2015

Relation: 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study.

Authors: Hsieh, Ming-Shun, Wu, Pei-Hsuan, Chiu, Kuan-Chih, Liao, Shu-Hui, Chen, Che-Shao, Hsiao, Tzu-Hung, Chen, Yi-Ming, Hu, Sung-Yuan, How, Chorng-Kuang, Chattopadhyay, Amrita, Lu, Tzu-Pin

Source: Journal of Intensive Care; 2/26/2025, Vol. 13 Issue 1, p1-13, 13p

Subject Terms: GENETIC risk score, GENETIC variation, RECEIVER operating characteristic curves, PROGNOSTIC models, SEPSIS

ARTN and CCL23 predicted chemosensitivity in acute myeloid leukemia: an Olink^® proteomics approach.

Authors: Wu, Ting-Shuan^1,2 (AUTHOR), Hsiao, Tzu-Hung^3,4,5,6 (AUTHOR), Chen, Chung-Hsing⁷ (AUTHOR), Li, Hsin-Ni^8,9 (AUTHOR), Hung, Miao-Neng¹ (AUTHOR), Jhan, Pei-Pei³ (AUTHOR), Tsai, Jia-Rung¹⁰ (AUTHOR), Teng, Chieh-Lin Jerry^{9,10,11,12,13,14} (AUTHOR) drteng@vghtc.gov.tw

Source: Clinical Proteomics. 1/21/2025, Vol. 22 Issue 1, p1-9. 9p.

Subject Terms: *ACUTE myeloid leukemia, *IMMUNOSTAINING, *ENZYME-linked immunosorbent assay, *BLOOD proteins, *GENE expression

Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme

Authors: Chiu, Yu-Chiao, Chuang, Eric Y., Hsiao, Tzu-Hung, Chen, Yidong

Source: 2013 IEEE International Conference on Bioinformatics and Biomedicine Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on. :201-204 Dec, 2013

Relation: 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

An investigation of clinical outcome prediction from integrative genomic profiles in ovarian cancer

Authors: Zhang, Lin, Liu, Hui, Hsiao, Tzu-Hung, Chen, Yidong, Huang, Yufei

Source: Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) Genomic Signal Processing and Statistics, (GENSIPS), 2012 IEEE International Workshop on. :103-106 Dec, 2012

Relation: 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

Identification of functional genomic regions with copy number alteration in liver cancer

Authors: Hsiao, Tzu-Hung, Chen, Hung-I Harry, Chen, Yidong

Source: Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) Genomic Signal Processing and Statistics, (GENSIPS), 2012 IEEE International Workshop on. :155-158 Dec, 2012

Relation: 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

Using gene sets to identify putative drugs for breast cancer

Authors: Hsiao, Tzu-Hung, Chen, Hung-I Harry, Chen, Yidong, Chen, Yu-Heng, Chuang, Eric Y.

Source: 2012 IEEE International Conference on Bioinformatics and Biomedicine Bioinformatics and Biomedicine (BIBM), 2012 IEEE International Conference on. :1-4 Oct, 2012

Relation: 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Identifying genes associated with chemotherapy response in ovarian carcinomas based on DNA copy number and expression profiles

Authors: Hsu, Fang-Han, Serpedin, Erchin, Hsiao, Tzu-Hung, Bishop, Alexander J.R., Dougherty, Edward R., Chen, Yidong

Source: 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on. :46-49 Dec, 2011

Relation: 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)