Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents

Authors: Zorbaz, Tamara, Malinak, David, Hofmanova, Tereza, Maraković, Nikola, Žunec, Suzana, Hrvat, Nikolina Maček, Andrys, Rudolf, Psotka, Miroslav, Zandona, Antonio, Svobodova, Jana, Prchal, Lukas, Fingler, Sanja, Katalinić, Maja, Kovarik, Zrinka, Musilek, Kamil

Source: In European Journal of Medicinal Chemistry 5 August 2022 238

Counteracting poisoning with chemical warfare nerve agents

Authors: Hrvat Nikolina Maček, Kovarik Zrinka

Source: Arhiv za Higijenu Rada i Toksikologiju, Vol 71, Iss 4, Pp 266-284 (2020)

Subject Terms: bioscavenger, cholinesterases, cyclosarin, novichoks, organophosphate, sarin, tabun, vx, biološka čistila, ciklosarin, kolinesteraze, novichok, organofosfati, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1848-6312

Access URL: https://doaj.org/article/6dcf4b0eefab43ad9f5d98d3803c78a3

Reversal of Tabun Toxicity Enabled by a Triazole‐Annulated Oxime Library—Reactivators of Acetylcholinesterase

Authors: Kovarik, Zrinka, Kalisiak, Jarosław, Hrvat, Nikolina Maček, Katalinić, Maja, Zorbaz, Tamara, Žunec, Suzana, Green, Carol, Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: Chemistry. 25(16):4100-4114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082925914.0x000001&indx=1&recIds=ETOCvdc_100082925914.0x000001

Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning

Authors: Katalinić, Maja, Hrvat, Nikolina Maček, Karasová, Jana Žďárová, Misik, Jan, Kovarik, Zrinka

Source: Arhiv za higijenu rada i toksikologiju. 66(4):291-298

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN604326782&indx=1&recIds=ETOCRN604326782

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Counteracting poisoning with chemical warfare nerve agents

Authors: Hrvat, Nikolina Maček, Kovarik, Zrinka

Source: Archives of Industrial Hygiene and Toxicology; December 2020, Vol. 71 Issue: 4 p266-284, 19p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors.

Authors: Čadež, Tena, Grgičević, Ana, Ahmetović, Ramiza, Barić, Danijela, Hrvat, Nikolina Maček, Kovarik, Zrinka, Škorić, Irena, McPhee, Derek J.

Source: Molecules; Nov2020, Vol. 25 Issue 21, p4872, 1p

Subject Terms: CHOLINESTERASE inhibitors, OXIME derivatives, OCTENE, OXIMES, ACETYLCHOLINESTERASE, ETHER derivatives, DRUG development

This result is not displayed to guests.
Login for full access.

PHENYLTETRAHYDROISOQUINOLINE-BASED TRIAZOLE COMPOUNDS ARE HIGH-AFFINITY POTENTIAL REACTIVATORS OF NERVE AGENT-INHIBITED HUMAN ACETYLCHOLINESTERASE.

Authors: Hrvat, Nikolina Maček, Kalisiak, Jarosław, Zandona, Antonio, Šinko, Goran, Radić, Zoran, Sharpless, K. Barry, Taylor, Palmer, Kovarik, Zrinka

Source: Military Medical Science Letters / Vojenské zdravotnické Listy; 2018 Supplement, Vol. 87, p89-89, 1p

Subject Terms: TRIAZOLES, ACETYLCHOLINESTERASE, MOLECULAR docking, ALDOXIMES, CELL-mediated cytotoxicity

ENHANCEMENT IN PYRIDINIUM OXIME-ASSISTED REACTIVATION OF TABUN-INHIBITED ACETYLCHOLINESTERASE ACHIEVED BY ACTIVE SITE MUTATIONS.

Authors: Kovarik, Zrinka, Katalinić, Maja, Hrvat, Nikolina Maček, Šinko, Goran, Zorbaz, Tamara, Bosak, Anita

Source: Military Medical Science Letters / Vojenské zdravotnické Listy; 2018 Supplement, Vol. 87, p14-14, 1p

Subject Terms: PYRIDINIUM compounds, TABUN, ACETYLCHOLINESTERASE, BINDING sites, GENETIC mutation, NEURAL transmission