Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): In‐depth sinus surgery analysis

Authors: Fokkens, Wytske J., Mullol, Joaquim, Kennedy, David, Philpott, Carl, Seccia, Veronica, Kern, Robert C., Coste, André, Sousa, Ana R., Howarth, Peter H., Benson, Victoria S., Mayer, Bhabita, Yancey, Steve W., Chan, Robert, Gane, Simon B.

Source: Allergy. 78(3):812-821

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184528120.0x000001&indx=1&recIds=ETOCvdc_100184528120.0x000001

The Unified Airway Hypothesis: Evidence From Specific Intervention With Anti–IL-5 Biologic Therapy

Authors: Bachert, Claus, Luong, Amber U., Gevaert, Philippe, Mullol, Joaquim, Smith, Steven G., Silver, Jared, Sousa, Ana R., Howarth, Peter H., Benson, Victoria S., Mayer, Bhabita, Chan, Robert H., Busse, William W.

Source: In The Journal of Allergy and Clinical Immunology: In Practice September 2023 11(9):2630-2641

Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma

Authors: Khalfaoui, Latifa, Symon, Fiona A., Couillard, Simon, Hargadon, Beverley, Chaudhuri, Rekha, Bicknell, Steve, Mansur, Adel H., Shrimanker, Rahul, Hinks, Timothy S. C., Pavord, Ian D., Fowler, Stephen J., Brown, Vanessa, McGarvey, Lorcan P., Heaney, Liam G., Austin, Cary D., Howarth, Peter H., Arron, Joseph R., Choy, David F., Bradding, Peter

Source: Allergy. 77(10):2974-2986

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The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps

Authors: Gevaert, Philippe, Han, Joseph K., Smith, Steven G., Sousa, Ana R., Howarth, Peter H., Yancey, Steven W., Chan, Robert, Bachert, Claus

Source: International forum of allergy & rhinology. 12(11):1413-1423

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Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review

Authors: Israel,, Elliot, Canonica,, Giorgio Walter, Brusselle,, Guy, Yang,, Shibing, Howarth,, Peter H., Martin,, Amber L., Koufopoulou,, Maria, Smith,, Steven G., Alfonso-Cristancho,, Rafael

Source: Journal of asthma. 59(11):2201-2217

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Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation

Authors: Delgado-Eckert, Edgar ^∗, James, Anna ^∗, Meier-Girard, Delphine, Kupczyk, Maciej, Andersson, Lars I., Bossios, Apostolos, Mikus, Maria, Ono, Junya, Izuhara, Kenji, Middelveld, Roelinde, Dahlén, Barbro, Gaga, Mina, Siafakas, Nikos M., Papi, Alberto, Beghe, Bianca, Joos, Guy, Rabe, Klaus F., Sterk, Peter J., Bel, Elisabeth H., Johnston, Sebastian L., Chanez, Pascal, Gjomarkaj, Mark, Howarth, Peter H., Niżankowska-Mogilnicka, Ewa, Dahlén, Sven-Erik, Frey, Urs

Source: In The Journal of Allergy and Clinical Immunology August 2021 148(2):407-419

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

Authors: Adcock, Ian M, Azim, Adnam, Bellamy, Mary, Borg, Catherine, Bourne, Michelle, Connolly, Clare, Costello, Richard W, Corrigan, Chris J, Davies, Sarah, Davies, Gareth, Chung, Kian F, Gainsborough, Gabrielle, Grandison, Traceyanne, Hargadon, Beverley, Horn, Avril, Hudson, Val, Jackson, David, Johnston, Sebastian, Jones, Geraldine, McCourt, Paula, Nunez, Maria, Shaw, Dominic E, Smith, Katherine, Solis, Joel, Stone, Roisin, Yang, Freda, Heaney, Liam G ^*, Busby, John, Hanratty, Catherine E, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha M, Hardman, Timothy C, Arron, Joseph R, Choy, David F, Bradding, Peter, Brightling, Christopher E, Chaudhuri, Rekha, Cowan, Douglas C, Mansur, Adel H, Fowler, Stephen J, Niven, Robert M, Howarth, Peter H, Lordan, James L, Menzies-Gow, Andrew, Harrison, Tim W, Robinson, Douglas S, Holweg, Cecile T J, Matthews, John G, Pavord, Ian D

Source: In The Lancet Respiratory Medicine January 2021 9(1):57-68

Phenotypic and functional translation of IL33 genetics in asthma

Authors: Ketelaar, Maria E., Portelli, Michael A., Dijk, F. Nicole, Shrine, Nick, Faiz, Alen, Vermeulen, Cornelis J., Xu, Cheng J., Hankinson, Jenny, Bhaker, Sangita, Henry, Amanda P., Billington, Charlote K., Shaw, Dominick E., Johnson, Simon R., Benest, Andrew V., Pang, Vincent, Bates, David O., Pogson, Z.E.K., Fogarty, Andrew, McKeever, Tricia M., Singapuri, Amisha, Heaney, Liam G., Mansur, Adel H., Chaudhuri, Rekha, Thomson, Neil C., Holloway, John W., Lockett, Gabrielle A., Howarth, Peter H., Niven, Robert, Simpson, Angela, Tobin, Martin D., Hall, Ian P., Wain, Louise V., Blakey, John D., Brightling, Christopher E., Obeidat, Ma'en, Sin, Don D., Nickle, David C., Bossé, Yohan, Vonk, Judith M., van den Berge, Maarten, Koppelman, Gerard H., Sayers, Ian, Nawijn, Martijn C.

Source: In The Journal of Allergy and Clinical Immunology January 2021 147(1):144-157

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months

Authors: Abdel-Aziz, Mahmoud I., Brinkman, Paul, Vijverberg, Susanne J.H., Neerincx, Anne H., Riley, John H., Bates, Stewart, Hashimoto, Simone, Kermani, Nazanin Zounemat, Chung, Kian Fan, Djukanovic, Ratko, Dahlén, Sven-Erik, Adcock, Ian M., Howarth, Peter H., Sterk, Peter J., Kraneveld, Aletta D., Maitland-van der Zee, Anke H.

Source: In The Journal of Allergy and Clinical Immunology January 2021 147(1):123-134

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

Authors: Heaney, Liam G, Busby, John, Hanratty, Catherine E, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha M, Hardman, Timothy C, Arron, Joseph R, Choy, David F, Bradding, Peter, Brightling, Christopher E, Chaudhuri, Rekha, Cowan, Douglas C, Mansur, Adel H, Fowler, Stephen J, Niven, Robert M, Howarth, Peter H, Lordan, James L, Menzies-Gow, Andrew, Harrison, Tim W, Robinson, Douglas S, Holweg, Cecile T J, Matthews, John G, Pavord, Ian D

Source: Lancet.Respiratory medicine. 9(1):57-68

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Sputum processing by mechanical dissociation: A rapid alternative to traditional sputum assessment approaches

Authors: Barber, Clair, Lau, Laurie, Ward, Jonathan A., Daniels, Thomas, Watson, Alastair, Staples, Karl J., Wilkinson, Tom M. A., Howarth, Peter H.

Source: Clinical respiratory journal. 15(7):800-807

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123640242.0x000001&indx=1&recIds=ETOCvdc_100123640242.0x000001

Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U‐BIOPRED severe asthma study

Authors: Wilson, Susan J, Ward, Jonathan A, Pickett, Helen M, Baldi, Simonetta, Sousa, Ana R, Sterk, Peter J, Chung, Kian Fan, Djukanovic, Ratko, Dahlen, Barbro, Billing, Bo, Shaw, Dominick, Krug, Norbert, Sandstrӧm, Thomas, Brightling, Christopher, Howarth, Peter H

Source: Clinical & experimental allergy. 51(2):296-304

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123024618.0x000001&indx=1&recIds=ETOCvdc_100123024618.0x000001

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.

Authors: Meys, Roy, Franssen, Frits M.E., Van 't Hul, Alex J., Bakke, Per S., Caruso, Massimo, Dahlén, Barbro, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter H., Horváth, Ildikó, Krug, Norbert, Behndig, Annelie F., Singer, Florian, Musial, Jacek, Shaw, Dominick E., Montuschi, Paolo, Zee, Anke H. Maitland-van der, Sterk, Peter J., Roberts, Graham, Kermani, Nazanin Z.

Source: Health & Quality of Life Outcomes; 12/20/2024, Vol. 22 Issue 1, p1-10, 10p

Subject Terms: HEALTH outcome assessment, EPWORTH Sleepiness Scale, PATIENT reported outcome measures, MEDICAL sciences, PATIENT compliance

Species‐level, metagenomic and proteomic analysis of microbe‐immune interactions in severe asthma.

Authors: Jabeen, Maisha F., Sanderson, Nicholas D., Tinè, Mariaenrica, Donachie, Gillian, Barber, Clair, Azim, Adnan, Lau, Laurie C. K., Brown, Thomas, Pavord, Ian D., Chauhan, Anoop, Klenerman, Paul, Street, Teresa L., Marchi, Emanuele, Howarth, Peter H., Hinks, Timothy S. C.

Source: Allergy; Nov2024, Vol. 79 Issue 11, p2966-2980, 15p

Subject Terms: BASIC proteins, NASAL irrigation, INFLAMMATORY mediators, MICROBIAL diversity, BAYESIAN analysis, MYCOPLASMA pneumoniae infections

Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils.

Authors: Buchheit, Kathleen M., Shaw, Dominick, Chupp, Geoffrey, Lehtimaki, Lauri, Heffler, Enrico, Finney‐Hayward, Tricia, Zangrilli, James, Kwiatek, Justin, Siddiqui, Salman, Roufosse, Florence, Thamboo, Andrew, West, Nicholas, Vichiendilokkul, Anna, Hellings, Peter W., Peters, Anju, Howarth, Peter H.

Source: Allergy; Oct2024, Vol. 79 Issue 10, p2662-2679, 18p

Subject Terms: REGULATORY T cells, INNATE lymphoid cells, EPITHELIAL cells, EOSINOPHILS, PLASMA cells

Therapeutic relevance of eosinophilic inflammation and airway viral interactions in severe asthma.

Authors: Rupani, Hitasha, Busse, William W., Howarth, Peter H., Bardin, Philip G., Adcock, Ian M., Konno, Satoshi, Jackson, David J.

Source: Allergy; Oct2024, Vol. 79 Issue 10, p2589-2604, 16p

Subject Terms: RESPIRATORY infections, EOSINOPHILS, ASTHMATICS, BIOTHERAPY, VIRUS diseases

ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma—implications for COVID-19

Authors: Bradding, Peter, Richardson, Matthew, Hinks, Timothy S.C., Howarth, Peter H., Choy, David F., Arron, Joseph R., Wenzel, Sally E., Siddiqui, Salman

Source: Journal of allergy and clinical immunology. 146(1):208-211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121062220.0x000001&indx=1&recIds=ETOCvdc_100121062220.0x000001

Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma

Authors: Wardlaw, Andrew, Howarth, Peter H., Israel, Elliot, Taillé, Camille, Quirce, Santiago, Mallett, Stephen, Bates, Stewart, Albers, Frank C., Kwon, Namhee

Source: Clinical & experimental allergy. 50(7):869-872

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107430684.0x000001&indx=1&recIds=ETOCvdc_100107430684.0x000001

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Authors: Adcock, I.M., Ahmed, H., Auffray, C., Bakke, P., Bansal, A.T., Baribaud, F., Bates, S., Bel, E.H., Bigler, J., Bisgaard, H., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Brinkman, P., Bucchioni, E., Burg, D., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, F.K., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., De Meulder, B., Djukanovic, R., Erpenbeck, V.J., Erzen, D., Fichtner, K., Fitch, N., Fleming, L.J., Formaggio, E., Fowler, S.J., Frey, U., Gahlemann, M., Geiser, T., Goss, V., Guo, Y., Hashimoto, S., Haughney, J., Hedlin, G., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., Horváth, I., James, A.J., Knowles, R., Knox, A.J., Krug, N., Lefaudeux, D., Loza, M.J., Manta, A., Matthews, J.G., Mazein, A., Meiser, A., Middelveld, R.J.M., Miralpeix, M., Montuschi, P., Mores, N., Murray, C.S., Musial, J., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Postle, A., Powel, P., Praticò, G., Rao, N., Riley, J., Roberts, A., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Seibold, W., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Aalderen, W.M., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J., Jevnikar, Zala, Östling, Jörgen, Ax, Elisabeth, Calvén, Jenny, Thörn, Kristofer, Israelsson, Elisabeth, Öberg, Lisa, Singhania, Akul, Lau, Laurie C.K., Wilson, Susan J., Ward, Jonathan A., Chauhan, Anoop, Sousa, Ana R., De Meulder, Bertrand, Loza, Matthew J., Baribaud, Frédéric, Sterk, Peter J., Chung, Kian Fan, Sun, Kai, Guo, Yike, Adcock, Ian M., Payne, Debbie, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens M., Sandström, Thomas, Djukanovic, Ratko, James, Anna, Hinks, Timothy S.C., Howarth, Peter H., Vaarala, Outi, van Geest, Marleen ^∗, Olsson, Henric ^∗

Source: In The Journal of Allergy and Clinical Immunology February 2019 143(2):577-590

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

Authors: Shrine, Nick, Portelli, Michael A, John, Catherine, Soler Artigas, María, Bennett, Neil, Hall, Robert, Lewis, Jon, Henry, Amanda P, Billington, Charlotte K, Ahmad, Azaz, Packer, Richard J, Shaw, Dominick, Pogson, Zara E K, Fogarty, Andrew, McKeever, Tricia M, Singapuri, Amisha, Heaney, Liam G, Mansur, Adel H, Chaudhuri, Rekha, Thomson, Neil C, Holloway, John W, Lockett, Gabrielle A, Howarth, Peter H, Djukanovic, Ratko, Hankinson, Jenny, Niven, Robert, Simpson, Angela, Chung, Kian Fan, Sterk, Peter J, Blakey, John D, Adcock, Ian M, Hu, Sile, Guo, Yike, Obeidat, Maen, Sin, Don D, van den Berge, Maarten, Nickle, David C, Bossé, Yohan, Tobin, Martin D, Hall, Ian P, Brightling, Christopher E, Wain, Louise V, Sayers, Ian

Source: In The Lancet Respiratory Medicine January 2019 7(1):20-34