Condensation and compartmentalization of synaptic proteins underlying synaptic transmission and plasticity

Authors: Hosokawa, Tomohisa

Source: Seikagaku. 94(4):523-528

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Regulation of synaptic nanodomain by liquid–liquid phase separation: A novel mechanism of synaptic plasticity

Authors: Liu, Pin-Wu, Hosokawa, Tomohisa, Hayashi, Yasunori

Source: In Current Opinion in Neurobiology August 2021 69:84-92

Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif

Authors: Eriksen, Maria S., Nikolaienko, Oleksii, Hallin, Erik I., Grødem, Sverre, Bustad, Helene J., Flydal, Marte I., Merski, Ian, Hosokawa, Tomohisa, Lascu, Daniela, Akerkar, Shreeram, Cuéllar, Jorge, Chambers, James J., O'Connell, Rory, Muruganandam, Gopinath, Loris, Remy, Touma, Christine, Kanhema, Tambudzai, Hayashi, Yasunori, Stratton, Margaret M., Valpuesta, José M., Kursula, Petri, Martinez, Aurora, Bramham, Clive R.

Source: FEBS journal. 288(9):2930-2955

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Novel mechanism of synaptic plasticity mediated by CaMKII

Authors: Hayashi, Yasunori, Hosokawa, Tomohisa, Liu, Pin Wu, Saneyoshi, Takeo

Source: Seikagaku. 93(2):191-202

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626526419&indx=1&recIds=ETOCRN626526419

Editorial: Spatio-temporal molecular mechanisms regulating synapse function and neural circuit dynamics.

Authors: Hosokawa, Tomohisa, Kubota, Yoshiyuki, Takano, Tetsuya

Source: Frontiers in Molecular Neuroscience; 2025, p1-3, 3p

Subject Terms: NEURAL circuitry, NEUROLOGICAL disorders, MENTAL illness, NEUROPLASTICITY, DENTATE gyrus, AMYOTROPHIC lateral sclerosis, NEURAL transmission

Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

Authors: Cai, Qixu, Hosokawa, Tomohisa, Zeng, Menglong, Hayashi, Yasunori, Zhang, Mingjie

Source: In Structure 3 March 2020 28(3):290-300

BPS2025 - Shaping condensates: The role of protein structure in multiphase separation

Authors: Pandey, Vikas ¹, Hosokawa, Tomohisa ², Hayashi, Yasunori ², Urakubo, Hidetoshi ¹

Source: In Biophysical Journal 13 February 2025 124(3) Supplement 1:197a-197a

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

Authors: Kobayashi, Hiroyuki, Saito, Taro, Sato, Ko, Furusawa, Kotaro, Hosokawa, Tomohisa, Tsutsumi, Koji, Asada, Akiko, Kamada, Shinji, Ohshima, Toshio, Hisanaga, Shin-ichi

Source: In Journal of Biological Chemistry 11 July 2014 289(28):19627-19636

Stoichiometry and Phosphoisotypes of Hippocampal AMPA-Type Glutamate Receptor Phosphorylation

Authors: Hosokawa, Tomohisa, Mitsushima, Dai, Kaneko, Rina, Hayashi, Yasunori

Source: Neuron. 85(1):60-67

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064112455.0x000001&indx=1&recIds=ETOCvdc_100064112455.0x000001

Quantitative Measurement of in Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE

Authors: Hosokawa, Tomohisa ^{‡, §}, Saito, Taro ^‡, Asada, Akiko ^‡, Fukunaga, Kohji ^¶, Hisanaga, Shin-ichi ^{‡, ‖}

Source: In Molecular & Cellular Proteomics June 2010 9(6):1133-1143

Multiphasic protein condensation governed by shape and valency

Authors: Pandey, Vikas, Hosokawa, Tomohisa, Hayashi, Yasunori, Urakubo, Hidetoshi

Source: Cell Reports; 20250101, Issue: Preprints

Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation.

Authors: Hosokawa, Tomohisa, Liu, Pin-Wu

Source: Frontiers in Physiology; 12/16/2021, Vol. 12, p1-7, 7p

Subject Terms: MEMBRANE proteins, PHASE separation, NEUROPLASTICITY, NEURAL circuitry, NEURAL transmission

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CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation

Authors: Hosokawa, Tomohisa, Liu, Pin-Wu, Cai, Qixu, Ferreira, Joana S., Levet, Florian, Butler, Corey, Sibarita, Jean-Baptiste, Choquet, Daniel, Groc, Laurent, Hosy, Eric, Zhang, Mingjie, Hayashi, Yasunori

Source: Nature Neuroscience; June 2021, Vol. 24 Issue: 6 p777-785, 9p

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Interplay of enzymatic and structural functions of Ca MKII in long-term potentiation.

Authors: Kim, Karam, Saneyoshi, Takeo, Hosokawa, Tomohisa, Okamoto, Kenichi, Hayashi, Yasunori

Source: Journal of Neurochemistry; Dec2016, Vol. 139 Issue 6, p959-972, 14p

Subject Terms: LONG-term potentiation, ENZYMATIC analysis, PROTEIN kinases, BRAIN function localization, DENDRITIC spines

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