Goals of Care Discussion Characteristics and Disparities in Children With Medical Complexity

Authors: Monroe, Bryan S. ^{a, b, ⁎, 1}, Nazareth-Pidgeon, Kristina ^{a, b}, Daniel, Katherine B. ^c, Ming, David Y. ^{a, b, d, e}, Jordan, Megan ^{b, d, e}, DiCarlo, Camille ^f, Spangler, Anna ^g, Washabaugh, Claire E. ^c, Hornik, Christoph P. ^{b, h}, Chandler, Mark ^{a, b, d, e}

Source: In Academic Pediatrics May-June 2025 25(4)

Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus

Authors: Langel, Stephanie N. ^a, Otero, Claire E. ^b, Steppe, Justin T. ^b, Williams, Caitlin A. ^c, Travieso, Tatiana ^d, Chang, Jerry ^d, Webster, Helen ^d, Williamson, Lauren E. ^{e, f, g}, Crowe, James E., Jr ^{e, f, g}, Greenberg, Harry B. ^{h, i}, Wu, Huali ^j, Hornik, Christoph P. ^{j, k}, Mansouri, Katayoun ^d, Edwards, Robert J. ^{d, l}, Stalls, Victoria ^d, Acharya, Priyamvada ^{d, m}, Blasi, Maria ^{d, l, ⁎}, Permar, Sallie R. ^{c, ⁎⁎}

Source: In Mucosal Immunology April 2025 18(2):441-452

Embracing Generative Artificial Intelligence in Clinical Research and Beyond: Opportunities, Challenges, and Solutions

Authors: Foote, Henry P. ^a, Hong, Chuan ^{b, c}, Anwar, Mohd ^d, Borentain, Maria ^e, Bugin, Kevin ^f, Dreyer, Nancy ^g, Fessel, Josh ^h, Goyal, Nitender ⁱ, Hanger, Morgan ^j, Hernandez, Adrian F. ^c, Hornik, Christoph P. ^c, Jackman, Jennifer G. ^c, Lindsay, Alistair C. ^k, Matheny, Michael E. ^l, Ozer, Kerem ^m, Seidel, Jan ⁿ, Stockbridge, Norman ^f, Embi, Peter J. ^l, Lindsell, Christopher J. ^{c, ∗}

Source: In JACC: Advances March 2025 4(3)

Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

Authors: Selvaraj, Senthil ^{a, b, c, d, ∗}, Kwee, Lydia Coulter ^b, Thompson, Elizabeth J. ^{e, f}, He, Mengshu ^b, Hornik, Christoph P. ^{e, f}, Devore, Adam D. ^{a, f}, Patel, Chetan B. ^a, Mentz, Robert J. ^{a, f}, Fudim, Marat ^{a, f}, Taylor, Lacey ^a, Milosovic, Stephanie ^{b, g}, Hurdle, Melissa ^b, Cade, William T. ^{b, g}, Ilkayeva, Olga ^{b, h}, Muehlbauer, Michael J. ^b, Newgard, Christopher B. ^b, Kelly, Daniel P. ^{c, d}, Zamani, Payman ^{c, d}, Margulies, Kenneth B. ^{c, d}, Shah, Svati H. ^{a, b, f}

Source: In JACC: Basic to Translational Science March 2025 10(3):290-303

Framework of the strengths and challenges of clinically integrated trials: An expert panel report

Authors: Peters, Anthony E., Jones, W. Schuyler, Anderson, Brian, Bramante, Carolyn T., Broedl, Uli, Hornik, Christoph P., Kehoe, Lindsay, Knowlton, Kirk U., Krofah, Esther, Landray, Martin, Locke, Trevan, Patel, Manesh R., Psotka, Mitchell, Rockhold, Frank W., Roessig, Lothar, Rothman, Russell L., Schofield, Lesley, Stockbridge, Norman, Trontell, Anne, Curtis, Lesley H., Tenaerts, Pamela, Hernandez, Adrian F.

Source: In American Heart Journal September 2024 275:62-73

Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank

Authors: Krychtiuk, Konstantin A., Andersson, Tomas LG, Bodesheim, Ulrike, Butler, Javed, Curtis, Lesley H., Elkind, Mitchell, Hernandez, Adrian F., Hornik, Christoph, Lyman, Gary H., Khatri, Pooja, Mbagwu, Michael, Murakami, Masahiro, Nichols, Gwen, Roessig, Lothar, Young, Anne Quinn, Schilsky, Richard L., Pagidipati, Neha

Source: In American Heart Journal April 2024 270:23-43

A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility

Authors: Thompson, Elizabeth J., Foote, Henry P., Hill, Kevin D., Hornik, Christoph P.

Source: In Contemporary Clinical Trials Communications October 2023 35

“Click and mortar” opportunities for digitization and consumerism in trials

Authors: Randell, Rachel L., Hornik, Christoph P., Curtis, Lesley, Hernandez, Adrian F., Denwood, Tom, Nebeker, Camille, Sugarman, Jeremy, Tyl, Benoit, Murakami, Masahiro, Oley Wilberforce, Leslie, Pagoto, Sherry, Vedin, Ola, Andersson, Tomas, Carrasquillo, Olveen, Dolor, Rowena, Kollins, Scott H., Pellegrino, Jill, Ranney, Megan L.

Source: In Contemporary Clinical Trials September 2023 132

More Than a Headache: Lived Experience of Migraine in Youth

Authors: Canfora, Madison, Pallotto, Isabella K., Davis, J. Kelly, Farley, Samantha, Khayata, Matthew J., Hornik, Christoph P., Reeve, Bryce B., Rikhi, Aruna, Gelfand, Amy A., Szperka, Christina L., Kessel, Shirley, Pezzuto, Tara, Hammett, Alex, Lemmon, Monica E.

Source: In Pediatric Neurology September 2023 146:79-84

Phase I study of liver depot gene therapy in late-onset Pompe disease

Authors: Smith, Edward C., Hopkins, Sam, Case, Laura E., Xu, Ming, Walters, Crista, Dearmey, Stephanie, Han, Sang-oh, Spears, Tracy G., Chichester, Jessica A., Bossen, Edward H., Hornik, Christoph P., Cohen, Jennifer L., Bali, Deeksha, Kishnani, Priya S., Koeberl, Dwight D.

Source: In Molecular Therapy 5 July 2023 31(7):1994-2004

Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience

Authors: Boutzoukas, Angelique E., Olson, Rachel, Sellers, Mary Ann, Fischer, Gwenyth, Hornik, Chi D., Alibrahim, Omar, Iheagwara, Kelechi, Abulebda, Kamal, Bass, Andora L., Irby, Katherine, Subbaswamy, Anjali, Zivick, Elizabeth E., Sweney, Jill, Stormorken, Anne G., Barker, Erin E., Lutfi, Riad, McCrory, Michael C., Costello, John M., Ackerman, Kate G., Munoz Pareja, Jennifer C., Dean, J. Michael, Abdelsamad, Nael, Hanley, Daniel F., Jr, Mould, W. Andrew, Lane, Karen, Stroud, Mary, Feger, Bryan J., Greenberg, Rachel G., Smith, P. Brian, Benjamin, Daniel K., Jr, Hornik, Christoph P., Zimmerman, Kanecia O., Becker, Mara L.

Source: In Contemporary Clinical Trials February 2023 125

A reappraisal of risk factors for hypertension after pediatric acute kidney injury.

Authors: Patel, Mital¹ mitpatel@wakehealth.edu, Hornik, Christoph², Diamantidis, Clarissa³, Selewski, David T.⁴, Gbadegesin, Rasheed⁵

Source: Pediatric Nephrology. May2024, Vol. 39 Issue 5, p1599-1605. 7p.

Subject Terms: *HYPERTENSION risk factors, *RISK assessment, *CONGENITAL heart disease, *RESEARCH funding, *MEDICAL prescriptions, *THERAPEUTICS, *RENAL replacement therapy, *SCIENTIFIC observation, *SEX distribution, *LOGISTIC regression analysis, *ACUTE kidney failure, *DISEASE prevalence, *AGE distribution, *ANTIHYPERTENSIVE agents, *MULTIVARIATE analysis, *HEMODIALYSIS, *EVALUATION of medical care, *TERTIARY care, *PEDIATRICS, *LONGITUDINAL method, *STATURE, *ODDS ratio, *CONFIDENCE intervals, *DATA analysis software, *HOSPITAL care of children

Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial

Authors: Lang, Jason E., Hornik, Chi D., Martz, Karen, Jacangelo, Juliana, Anand, Ravinder, Greenberg, Rachel, Hornik, Christoph, Zimmerman, Kanecia, Smith, P. Brian, Benjamin, Daniel K., Laughon, Matthew

Source: In Contemporary Clinical Trials Communications December 2022 30

Protocol for the Vitamin D Oral Replacement in Asthma (VDORA) study

Authors: James, Laura, O'Sullivan, Brian P., Majure, Mark, Lang, Jason, Ounpraseuth, Song, Hornik, Christoph, Baldner, Jamie, Garza, Maryann, Prior, Fred, Lee, Jeannette Y., Snowden, Jessica

Source: In Contemporary Clinical Trials September 2022 120

Going Places: An Active Transportation Intervention to Increase Youth Physical Activity, Durham, North Carolina, 2023–2024.

Authors: D'Agostino, Emily M., Neshteruk, Cody D., Li, Tang, Davis, Jeremiah, Granados, Isa, Kumar, Advika, Forde, Jeffrey, Hornik, Christoph P.

Source: American Journal of Public Health; May2025, Vol. 115 Issue 5, p693-697, 5p

Subject Terms: SELF-efficacy, EXERCISE intensity, DESCRIPTIVE statistics, TRANSPORTATION, HEALTH promotion, SOCIAL support, PHYSICAL activity, ADOLESCENCE

Geographic Terms: NORTH Carolina

Training the Next Generation of Pediatric Clinical Pharmacologists: Insights and Trainee Perspectives Over 10 Years.

Authors: Randell, Rachel L., Gelineau‐Morel, Rose, Thomas, Sydney, Gonzalez, Daniel, Leeder, J. Steven, Hornik, Christoph P.

Source: Journal of Clinical Pharmacology; Mar2025, Vol. 65 Issue 3, p389-395, 7p

Subject Terms: PHARMACOLOGY, LIFESTYLES, PHARMACY education, DIVERSITY training programs, RESEARCH funding, HEALTH occupations students, AT-risk people, DESCRIPTIVE statistics, MENTORING, PEDIATRICS, SURVEYS, PHARMACISTS, ENDOWMENT of research, STUDENT attitudes, LABOR supply, VOCATIONAL guidance, TIME

Postoperative Renal Failure, Shunt Type, and Mortality After Norwood Palliation

Authors: Chamberlain, Reid C., Andersen, Nicholas D., McCrary, Andrew W., Hornik, Christoph P., Hill, Kevin D.

Source: In The Annals of Thoracic Surgery June 2022 113(6):2046-2053

Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018

Authors: Stark, Ashley, Smith, P. Brian, Hornik, Christoph P., Zimmerman, Kanecia O., Hornik, Chi D., Pradeep, Sidart, Clark, Reese H., Benjamin, Daniel K., Jr., Laughon, Matthew, Greenberg, Rachel G.

Source: In The Journal of Pediatrics January 2022 240:66-71

Incidence of group B streptococcus early-onset sepsis in term neonates with second-line prophylaxis maternal intrapartum antibiotics: a multicenter retrospective study

Authors: Low, Jia Ming, Lee, Jan Hau, Foote, Henry P., Hornik, Christoph P., Clark, Reese H., Greenberg, Rachel G.

Source: In American Journal of Obstetrics and Gynecology June 2024 230(6):673-673

Limited utility of repeated vital sign monitoring during initiation of oral propranolol for complicated infantile hemangioma

Authors: Püttgen, Katherine B., Hansen, Leanna M., Lauren, Christine, Stefanko, Nicole, Mathes, Erin, Olsen, Gerilyn M., Tollefson, Megha M., Adams, Denise, Baselga, Eulalia, Chamlin, Sarah, Corey, Kristen, Frascari, Flora F., Frieden, Ilona J., Galligan, Eloise R., Gupta, Deepti, Haggstrom, Anita, Horii, Kimberly, Hornik, Christoph P., Klajn, Justyna, Liberman, Leonardo, Mancini, Anthony, Mannschreck, Diana, McGinness, Anelah, McCuaig, Catherine, Newell, Brandon, Nguyen, Henry, Nopper, Amy, Oyesanya, Tola, Powell, Julie, Reynolds, Megan, Rios, Monica, Siegel, Dawn H., Ward, Kendra, Garzon, Maria C., Frommelt, Peter, Drolet, Beth A.

Source: In Journal of the American Academy of Dermatology August 2021 85(2):345-352