Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse

Authors: Cai, Shi-Ying, Ge, Maoxu, Mennone, Albert, Hoque, Rafaz, Ouyang, Xinshou, Boyer, James L.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2020 9(4):679-688

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9

Authors: Manakkat Vijay, Godhev Kumar, Hu, Changyun, Peng, Jian, Garcia-Martinez, Irma, Hoque, Rafaz, Verghis, Rejina Mariam, Ma, Yun, Mehal, Wajahat Zafar, Shawcross, Debbie Lindsay, Wen, Li

Source: In Cellular and Molecular Gastroenterology and Hepatology 2019 8(4):609-623

β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

Authors: Chen, Yonglin, Ouyang, Xinshou, Hoque, Rafaz, Garcia-Martinez, Irma, Yousaf, Muhammad Nadeem, Tonack, Sarah, Offermanns, Stefan, Dubuquoy, Laurent, Louvet, Alexandre, Mathurin, Philippe, Massey, Veronica, Schnabl, Bernd, Bataller, Ramon Alberola, Mehal, Wajahat Zafar

Source: In Journal of Hepatology September 2018 69(3):687-696

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

Authors: Ouyang, Xinshou, Han, Sheng-Na, Zhang, Ji-Yuan, Dioletis, Evangelos, Nemeth, Balazs Tamas, Pacher, Pal, Feng, Dechun, Bataller, Ramon, Cabezas, Joaquin, Stärkel, Peter, Caballeria, Joan, Pongratz, Rebecca LePine, Cai, Shi-Ying, Schnabl, Bernd, Hoque, Rafaz, Chen, Yonglin, Yang, Wei-hong, Garcia-Martinez, Irma, Wang, Fu-Sheng, Gao, Bin, Torok, Natalie Julia, Kibbey, Richard Glenn, Mehal, Wajahat Zafar

Source: In Cell Metabolism 6 February 2018 27(2):339-350

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

Authors: Hoque, Rafaz, Farooq, Ahmad, Ghani, Ayaz, Gorelick, Fred, Mehal, Wajahat Zafar

Source: In Gastroenterology June 2014 146(7):1763-1774

Update on innate immunity and perspectives on metabolite regulation in acute pancreatitis

Authors: Hoque, Rafaz

Source: Current opinion in gastroenterology. 32(6):507-512

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100036485309.0x000001&indx=1&recIds=ETOCvdc_100036485309.0x000001

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response

Authors: Malik, Ahsan F., Hoque, Rafaz, Ouyang, Xinshou, Ghani, Ayaz, Hong, Enping, Khan, Khadija, Moore, Laura Beth, Ng, Gilbert, Munro, Fay, Flavell, Richard A., Shi, Yan, Kyriakides, Themis R., Mehal, Wajahat Z.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Dec . 108(50), 20095-20100.

Access URL: https://www.jstor.org/stable/23060081

Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB—Mediated Inflammatory Response in Mice

Authors: Fiorotto, Romina, Scirpo, Roberto, Trauner, Michael, Fabris, Luca, Hoque, Rafaz, Spirli, Carlo, Strazzabosco, Mario

Source: In Gastroenterology 2011 141(4):1498-1508

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

Authors: Hoque, Rafaz, Sohail, Muhammad, Malik, Ahsan, Sarwar, Sherhayar, Luo, Yuhuan, Shah, Ahsan, Barrat, Franck, Flavell, Richard, Gorelick, Fred, Husain, Sohail, Mehal, Wajahat

Source: In Gastroenterology 2011 141(1):358-369

Methods for transforming plants

Therapeutic strategies in inflammasome mediated diseases of the liver

Authors: Hoque, Rafaz, Vodovotz, Yoram, Mehal, Wajahat

Source: In Journal of Hepatology May 2013 58(5):1047-1052

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Authors: Garcia-Martinez, Irma, Santora, Nicola, Chen, Yonglin, Hoque, Rafaz, Ouyang, Xinshou, Caprio, Sonia, Shlomchik, Mark J., Coffman, Robert Lee, Candia, Albert, Mehal, Wajahat Zafar

Source: Journal of clinical investigation. 126(3):859-859

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605247311&indx=1&recIds=ETOCRN605247311

Ammonia Mediated Brain-oedema and Immune Dysfunction is Mediated by Toll-like Receptor (TLR) 9

Authors: Manakkat Vijay, Godhev K., Hu, Changyun, Peng, Jian, Martinez, Irma Garcia, Hoque, Rafaz, Zhang, Xiaojun, Ma, Yun, Mehal, Wajahat, Shawcross, Debbie, Wen, Li

Source: In Journal of Clinical and Experimental Hepatology February 2017 7 Supplement 1:S2-S3

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.

Authors: Taub, James, Lau, Joe F., Ma, Charles, Hahn, Jang Hee, Hoque, Rafaz, Rothblatt, Jonathan, Chalfie, Martin

Source: Nature. 5/13/1999, Vol. 399 Issue 6732, p162. 5p. 2 Color Photographs, 2 Black and White Photographs, 1 Chart, 11 Graphs.

Subjects: CAENORHABDITIS elegans, ANIMAL life spans, CATALASE, LARVAL physiology, PHYSIOLOGY, CYTOGENETICS

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