Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication

Authors: Guerrero Zuniga, Adler, Aikin, Timothy J., McKenney, Connor, Lendner, Yovel, Phung, Alain, Hook, Paul W., Meltzer, Amy, Timp, Winston, Regot, Sergi

Source: In Developmental Cell 8 July 2024 59(13):1724-1736

Nanopore decoding with speed and versatility for data storage.

Authors: Volkel, Kevin D¹ (AUTHOR), Hook, Paul W² (AUTHOR), Keung, Albert³ (AUTHOR), Timp, Winston² (AUTHOR), Tuck, James M¹ (AUTHOR)

Source: Bioinformatics. Jan2025, Vol. 41 Issue 1, p1-10. 10p.

Subject Terms: *ERROR rates, *DECODING algorithms, *DATA warehousing, *GENETIC transcription, *SOURCE code

Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease

Authors: Soto-Beasley, Alexandra I., Walton, Ronald L., Valentino, Rebecca R., Hook, Paul W., Labbé, Catherine, Heckman, Michael G., Johnson, Patrick W., Goff, Loyal A., Uitti, Ryan J., McLean, Pamela J., Springer, Wolfdieter, McCallion, Andrew S., Wszolek, Zbigniew K., Ross, Owen A.

Source: In Parkinsonism and Related Disorders September 2020 78:138-144

Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophrenia

Authors: Hook, Paul W., McCallion, Andrew S.

Source: Genome research. 30(4):528-539

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624593557&indx=1&recIds=ETOCRN624593557

Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons

Authors: McClymont, Sarah A., Hook, Paul W., Soto, Alexandra I., Reed, Xylena, Law, William D., Kerans, Samuel J., Waite, Eric L., Briceno, Nicole J., Thole, Joey F., Heckman, Michael G., Diehl, Nancy N., Wszolek, Zbigniew K., Moore, Cedric D., Zhu, Heng, Akiyama, Jennifer A., Dickel, Diane E., Visel, Axel, Pennacchio, Len A., Ross, Owen A., Beer, Michael A., McCallion, Andrew S.

Source: In The American Journal of Human Genetics 6 December 2018 103(6):874-892

Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

Authors: Hook, Paul W., McClymont, Sarah A., Cannon, Gabrielle H., Law, William D., Morton, A. Jennifer, Goff, Loyal A., McCallion, Andrew S.

Source: In The American Journal of Human Genetics 1 March 2018 102(3):427-446

Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA

Authors: Turner, Tychele N., Hormozdiari, Fereydoun, Duyzend, Michael H., McClymont, Sarah A., Hook, Paul W., Iossifov, Ivan, Raja, Archana, Baker, Carl, Hoekzema, Kendra, Stessman, Holly A., Zody, Michael C., Nelson, Bradley J., Huddleston, John, Sandstrom, Richard, Smith, Joshua D., Hanna, David, Swanson, James M., Faustman, Elaine M., Bamshad, Michael J., Stamatoyannopoulos, John, Nickerson, Deborah A., McCallion, Andrew S., Darnell, Robert, Eichler, Evan E.

Source: In The American Journal of Human Genetics 7 January 2016 98(1):58-74

FrameD: framework for DNA-based data storage design, verification, and validation.

Authors: Volkel, Kevin D¹, kvolkel@ncsu.edu, Lin, Kevin N², Hook, Paul W³, Timp, Winston³, Keung, Albert J², Tuck, James M¹, kvolkel@ncsu.edu

Source: Bioinformatics; Oct2023, Vol. 39 Issue 10, p1-8, 8p

A primordial DNA store and compute engine

Authors: Lin, Kevin N., Volkel, Kevin, Cao, Cyrus, Hook, Paul W., Polak, Rachel E., Clark, Andrew S., San Miguel, Adriana, Timp, Winston, Tuck, James M., Velev, Orlin D., Keung, Albert J.

Source: Nature Nanotechnology; 20240101, Issue: Preprints p1-11, 11p

The complete sequence of a human Y chromosome.

Authors: Rhie, Arang, Nurk, Sergey, Cechova, Monika, Hoyt, Savannah J., Taylor, Dylan J., Altemose, Nicolas, Hook, Paul W., Koren, Sergey, Rautiainen, Mikko, Alexandrov, Ivan A., Allen, Jamie, Asri, Mobin, Bzikadze, Andrey V., Chen, Nae-Chyun, Chin, Chen-Shan, Diekhans, Mark, Flicek, Paul, Formenti, Giulio, Fungtammasan, Arkarachai, Garcia Giron, Carlos

Source: Nature; Sep2023, Vol. 621 Issue 7978, p344-354, 11p

Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons.

Authors: Boyd, Rachel J., McClymont, Sarah A., Barrientos, Nelson B., Hook, Paul W., Law, William D., Rose, Rebecca J., Waite, Eric L., Rathinavelu, Jay, Avramopoulos, Dimitrios, McCallion, Andrew S.

Source: BMC Genomics; 6/7/2023, Vol. 24 Issue 1, p1-18, 18p

Subject Terms: MESENCEPHALON, DOPAMINERGIC neurons, NEURONAL differentiation, CELL lines, PARKINSON'S disease, GENOMICS

Beyond assembly: the increasing flexibility of single-molecule sequencing technology

Authors: Hook, Paul W., Timp, Winston

Source: Nature Reviews Genetics; September 2023, Vol. 24 Issue: 9 p627-641, 15p

Single-Cell RNA-Seq of Mouse Dopaminergic NeuronsInforms Candidate Gene Selection for Sporadic Parkinson Disease.

Authors: Hook, Paul W.¹, McClymont, Sarah A.¹, andy@jhmi.edu, Cannon, Gabrielle H.¹, Law, William D.², Morton, A. Jennifer^1,3, Goff, Loyal A.^1,4,5, loyalgoff@jhmi.edu

Source: American Journal of Human Genetics; Mar2018, Vol. 102 Issue 3, p427-446, 20p

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Epigenetic patterns in a complete human genome.

Authors: Gershman, Ariel, Sauria, Michael E. G., Guitart, Xavi, Vollger, Mitchell R., Hook, Paul W., Hoyt, Savannah J., Jain, Miten, Shumate, Alaina, Razaghi, Roham, Koren, Sergey, Altemose, Nicolas, Caldas, Gina V., Logsdon, Glennis A., Rhie, Arang, Eichler, Evan E., Schatz, Michael C., O’Neill, Rachel J., Phillippy, Adam M., Miga, Karen H., khmiga@ucsc.edu, Timp, Winston, wtimp@jhu.edu

Source: Science; 4/1/2022, Vol. 376 Issue 6588, p58-58, 1p, 1 Color Photograph