Enzymatic basis of the Fc-selective intra-chain disulfide reduction and free thiol content variability in an antibody produced in Escherichia coli

Authors: Tomasz K. Baginski, Karthik Veeravalli, Rebekah McKenna, Christopher Williams, Katherine Wong, Christina Tsai, Daniel Hewitt, Karthik Mani, Michael W. Laird

Source: Microbial Cell Factories, Vol 21, Iss 1, Pp 1-15 (2022)

Subject Terms: Antibody, Disulfide bond reduction, Free thiols, Fc glycosylation, Disulfide bond isomerase C (DsbC), Homogenate hold, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/4bf0565975cc45ce9f5a2e9b90ff2c0d