GPCR Function in Autophagy Control: A Systematic Approach of Chemical Intervention

Authors: Sanz-Martinez, Pablo, Tascher, Georg, Cano-Franco, Sara, Cabrerizo-Poveda, Paloma, Münch, Christian, Homan, Evert J., Stolz, Alexandra

Source: In Journal of Molecular Biology 1 August 2024 436(15)

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Authors: Zhang, Si Min ^{1, ∗}, Paulin, Cynthia B.J. ^{1, 4}, Shu, Huazhang ¹, Yagüe-Capilla, Miriam ¹, Michel, Maurice ¹, Marttila, Petra ¹, Ortis, Florian ¹, Bwanika, Henri Colyn ¹, Dirks, Christopher ¹, Venkatram, Rajagopal Papagudi ^{1, 5}, Wiita, Elisée ¹, Jemth, Ann-Sofie ¹, Almlöf, Ingrid ¹, Loseva, Olga ¹, Hormann, Femke M. ¹, Koolmeister, Tobias ¹, Linde, Erika ^{1, 6}, Lee, Sun ^{1, 7}, Llona-Minguez, Sabin ^{1, 8}, Haraldsson, Martin ², Axelsson, Hanna ², Strömberg, Kia ^{1, 9}, Homan, Evert J. ¹, Scobie, Martin ¹, Lundbäck, Thomas ^{2, 10}, Helleday, Thomas ^{1, 3}, Rudd, Sean G. ^{1, 11, ∗∗}

Source: In iScience 16 February 2024 27(2)

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

Authors: Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

Source: In Cell Chemical Biology 16 December 2021 28(12):1693-1702

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.

Authors: Digles, Daniela, Ingles-Prieto, Alvaro, Dvorak, Vojtech, Mocking, Tamara A. M., Goldmann, Ulrich, Garofoli, Andrea, Homan, Evert J., Di Silvio, Alberto, Azzollini, Lucia, Sassone, Francesca, Fogazza, Mario, Bärenz, Felix, Pommereau, Antje, Zuschlag, Yasmin, Ooms, Jasper F., Tranberg-Jensen, Jeppe, Hansen, Jesper S., Stanka, Josefina, Sijben, Hubert J., Batoulis, Helena

Source: Frontiers in Pharmacology; 2024, p1-16, 16p

Subject Terms: DRUG discovery, HIGH throughput screening (Drug development), WEB portals, SMALL molecules, DRUG development, TRACKING radar

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Authors: Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J., Hanna, Bishoy M. F., Paulin, Cynthia B. J., Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E., Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A., Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas

Source: Science, 2018 Nov . 362(6416), 834-839.

Access URL: https://www.jstor.org/stable/26569336

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors

Authors: Scaletti, Emma R., Gustafsson Westergren, Robert, Andersson, Yasmin, Wiita, Elisee, Henriksson, Martin, Homan, Evert J., Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål

Source: ChemMedChem. 17(18)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164933304.0x000001&indx=1&recIds=ETOCvdc_100164933304.0x000001

Front Cover: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (ChemMedChem 18/2022)

Authors: Scaletti, Emma R., Gustafsson Westergren, Robert, Andersson, Yasmin, Wiita, Elisee, Henriksson, Martin, Homan, Evert J., Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål

Source: ChemMedChem. 17(18)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164933333.0x000001&indx=1&recIds=ETOCvdc_100164933333.0x000001

PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands.

Authors: Simon, Icaro A., Homan, Evert J., Wijtmans, Maikel, Sundström, Michael, Leurs, Rob, De Esch, Iwan J. P., Zarzycka, Barbara A.

Source: Journal of Chemical Information & Modeling; 11/13/2023, Vol. 63 Issue 21, p6696-6705, 10p

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Authors: Michel, Maurice¹, maurice.grube@scilifelab.se, Benítez-Buelga, Carlos^1,2, Calvo, Patricia A.³, Hanna, Bishoy M. F.¹, Mortusewicz, Oliver¹, Masuyer, Geoffrey^4,5, Davies, Jonathan⁶, Wallner, Olov¹, Sanjiv, Kumar¹, Albers, Julian J.¹, Castañeda-Zegarra, Sergio^1,7, Jemth, Ann-Sofie¹, Visnes, Torkild⁸, Sastre-Perona, Ana⁹, Danda, Akhilesh N.¹, Homan, Evert J.¹, Marimuthu, Karthick¹, Zhenjun, Zhao¹, Chi, Celestine N.¹⁰, Sarno, Antonio¹¹

Source: Science; 6/24/2022, Vol. 376 Issue 6600, p1471-1476, 6p, 2 Diagrams, 1 Graph

C5-Substituted Derivatives of 5-OMe-BPAT: Synthesis and Interactions with Dopamine D2 and Serotonin 5-HT1A Receptors

Authors: Homan, Evert J. ^*, Tulp, Martin Th.M., Nilsson, Jonas E., Wikström, Håkan V., Grol, Cor J.

Source: In Bioorganic & Medicinal Chemistry November 1999 7(11):2541-2548

Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT

Authors: Homan, Evert J. ^*, Wikström, Håkan V., Grol, Cor J.

Source: In Bioorganic & Medicinal Chemistry September 1999 7(9):1805-1820

Synthesis and pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT

Authors: Homan, Evert J. ^*, Copinga, Swier, Unelius, Lena, Jackson, David M., Wikström, H̊kan V., Grol, Cor J.

Source: In Bioorganic & Medicinal Chemistry July 1999 7(7):1263-1271

Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D 2, D 3, and serotonin 5-HT 1A receptors

Authors: Homan, Evert J. ^{a, *}, Kroodsma, Esther ^a, Copinga, Swier ^b, Unelius, Lena ^b, Mohell, Nina ^b, Wikström, Håkan V. ^a, Grol, Cor J. ^a

Source: In Bioorganic & Medicinal Chemistry 1999 7(6):1111-1121

Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude

Authors: Drijfhout, Willem J, de Vries, Jan B, Homan, Evert J, Brons, Heleen F, Copinga, Swier, Gruppen, Gert, Beresford, Isabel J.M, Hagan, Russell M, Grol, Cor J, Westerink, Ben H.C ^*

Source: In European Journal of Pharmacology 1999 382(3):157-166

Development of a chemical probe against NUDT15

Authors: Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas

Source: Nature Chemical Biology; October 2020, Vol. 16 Issue: 10 p1120-1128, 9p

Computational and Experimental Druggability Assessment of Human DNA Glycosylases.

Authors: Michel, Maurice, Visnes, Torkild, Homan, Evert J., Seashore-Ludlow, Brinton, Hedenström, Mattias, Wiita, Elisée, Vallin, Karl, Paulin, Cynthia B. J., Jiaxi Zhang, Wallner, Olov, Scobie, Martin, Schmidt, Andreas, Jenmalm-Jensen, Annika, Warpman Berglund, Ulrika, Helleday, Thomas

Source: ACS Omega; 7/31/2019, Vol. 4 Issue 7, p11642-11656, 15p

This result is not displayed to guests.
Login for full access.

Molecular modeling of the dopamine D2and serotonin 5-HT1Areceptor binding modes of the enantiomers of 5-OMe-BPAT

Authors: Homan, Evert J., Wikström, Håkan V., Grol, Cor J.

Source: Bioorganic & Medicinal Chemistry; September 1999, Vol. 7 Issue: 9 p1805-1820, 16p

C5-Substituted Derivatives of 5-OMe-BPAT: Synthesis and Interactions with Dopamine D2and Serotonin 5-HT1AReceptors

Authors: Homan, Evert J., Tulp, Martin Th.M., Nilsson, Jonas E., Wikström, Håkan V., Grol, Cor J.

Source: Bioorganic & Medicinal Chemistry; November 1999, Vol. 7 Issue: 11 p2541-2548, 8p

This result is not displayed to guests.
Login for full access.