B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells

Authors: Gutknecht, Michael F. ^{1, 2, ∗}, Holodick, Nichol E. ¹, Rothstein, Thomas L. ¹

Source: In iScience 15 September 2023 26(9)

Sex Influences Age-Related Changes in Natural Antibodies and CD5^+ B-1 Cells

Authors: Webster, Sarah E., Ryali, Brinda, Clemente, Michael J., Tsuji, Naomi L., Holodick, Nichol E.

Source: Journal of immunology. 208(7):1755-1771

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629114048&indx=1&recIds=ETOCRN629114048

Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging.

Authors: Webster, Sarah E., Les, Sydney M., Deleon, Nico, Heck, Daken M., Tsuj, Naomi L., Clemente, Michael J., Jones, Prentiss, Holodick, Nichol E.

Source: Immunity & Ageing; 2/24/2025, Vol. 22 Issue 1, p1-18, 18p

Subject Terms: IMMUNOGLOBULIN M, MEDICAL sciences, VISION disorders, MACULAR degeneration, VITREOUS humor

Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age

Authors: Tsuji, Naomi, Rothstein, Thomas L., Holodick, Nichol E.

Source: Journal of immunology. 205(3):741-759

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624358270&indx=1&recIds=ETOCRN624358270

Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis

Authors: Upadhye, Aditi, Srikakulapu, Prasad, Gonen, Ayelet, Hendrikx, Sabrina, Perry, Heather M., Nguyen, Anh, McSkimming, Chantel, Marshall, Melissa A., Garmey, James C., Taylor, Angela M., Bender, Timothy P., Tsimikas, Sotirios, Holodick, Nichol E., Rothstein, Thomas L., Witztum, Joseph L., McNamara, Coleen A.

Source: Circulation research. 125(10):e55-e70

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190016480.0x000001&indx=1&recIds=ETOCvdc_100190016480.0x000001

B-1a Cells Protect Mice from Sepsis: Critical Role of CREB

Authors: Aziz, Monowar, Holodick, Nichol E., Rothstein, Thomas L., Wang, Ping

Source: Journal of immunology. 199(2):750-760

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612179900&indx=1&recIds=ETOCRN612179900

Human B-1 and B-2 B Cells Develop from Lin^—CD34^+CD38^l^o Stem Cells

Authors: Quách, Tâm D., Hopkins, Thomas J., Holodick, Nichol E., Vuyyuru, Raja, Manser, Tim, Bayer, Ruthee-Lu, Rothstein, Thomas L.

Source: Journal of immunology. 197(10):3950-3958

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608727381&indx=1&recIds=ETOCRN608727381

Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age

Authors: Holodick, Nichol E., Vizconde, Teresa, Hopkins, Thomas J., Rothstein, Thomas L.

Source: Journal of immunology. 196(10):4348-4357

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606080333&indx=1&recIds=ETOCRN606080333

Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling

Authors: Chen, Shih-Shih, Batliwalla, Franak, Holodick, Nichol E., Yan, Xiao-Jie, Yancopoulos, Sophia, Croce, Carlo M., Rothstein, Thomas L., Chiorazzi, Nicholas

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Apr . 110(16), 6254-6254.

Access URL: https://www.jstor.org/stable/42590399

Human B1 cells and uses thereof

Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells

Authors: Holodick, Nichol E., Tumang, Joseph R., Rothstein, Thomas L.

Source: In Molecular Immunology September 2009 46(15):3029-3036

Age-related changes in antigen-specific natural antibodies are influenced by sex.

Authors: Webster, Sarah E., Tsuji, Naomi L., Clemente, Michael J., Holodick, Nichol E.

Source: Frontiers in Immunology; 1/12/2023, Vol. 13, p1-17, 17p

Subject Terms: SEX (Biology), GENDER differences (Sociology), B cell receptors, IMMUNOGLOBULINS, CELLULAR aging

B-1a cells protect mice from sepsis-induced acute lung injury

Authors: Aziz, Monowar, Ode, Yasumasa, Zhou, Mian, Ochani, Mahendar, Holodick, Nichol E., Rothstein, Thomas L., Wang, Ping

Source: Molecular medicine. 24(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100126175381.0x000001&indx=1&recIds=ETOCvdc_100126175381.0x000001

Modulation of microbiome diversity and cytokine expression is influenced in a sex-dependent manner during aging.

Authors: Webster, Sarah E., Vos, Duncan, Rothstein, Thomas L., Holodick, Nichol E.

Source: Frontiers in Microbiomes; 10/10/2022, p1-23, 23p

Subject Terms: AGING, HOMESITES, CYTOKINES, SEX (Biology), GUT microbiome, ORAL microbiology, MICROBIAL diversity

B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis.

Authors: Srikakulapu, Prasad, Pattarabanjird, Tanyaporn, Upadhye, Aditi, Bontha, Sai Vineela, Osinski, Victoria, Marshall, Melissa A., Garmey, James, Deroissart, Justine, Prohaska, Thomas A., Witztum, Joseph L., Binder, Christoph J., Holodick, Nichol E., Rothstein, Thomas L., McNamara, Coleen A.

Source: Frontiers in Immunology; 7/22/2022, Vol. 13, p1-11, 11p

Subject Terms: HOMEOSTASIS, CHEMOKINE receptors, IMMUNOGLOBULIN M, MICE, CHEMOKINES

B cells in the aging immune system: time to consider B-1 cells.

Authors: Holodick, Nichol E.¹, Rothstein, Thomas L.^1,2

Source: Annals of the New York Academy of Sciences. Dec2015, Vol. 1362 Issue 1, p176-187. 12p.

Subject Terms: *IMMUNE system, *PHYSIOLOGICAL aspects of aging, *B cells, *CYTOLOGY, *CELL growth, *PHYSIOLOGY

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