A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study

Authors: Dennis, John M ^{a, *}, Young, Katherine G ^a, Cardoso, Pedro ^a, Güdemann, Laura M ^a, McGovern, Andrew P ^a, Farmer, Andrew ^b, Holman, Rury R ^{c, d}, Sattar, Naveed ^e, McKinley, Trevelyan J ^a, Pearson, Ewan R ^f, Jones, Angus G ^a, Shields, Beverley M ^a, Hattersley, Andrew T ^a

Source: In The Lancet 1-7 March 2025 405(10480):701-714

Younger-onset compared with later-onset type 2 diabetes: an analysis of the UK Prospective Diabetes Study (UKPDS) with up to 30 years of follow-up (UKPDS 92)

Authors: Lin, Beryl, Coleman, Ruth L, Bragg, Fiona, Maddaloni, Ernesto, Holman, Rury R, Adler, Amanda I ^*

Source: In The Lancet Diabetes & Endocrinology December 2024 12(12):904-914

Post-trial monitoring of a randomised controlled trial of intensive glycaemic control in type 2 diabetes extended from 10 years to 24 years (UKPDS 91)

Authors: Adler, Amanda I, Coleman, Ruth L, Leal, Jose, Whiteley, William N, Clarke, Philip, Holman, Rury R ^*

Source: In The Lancet 13-19 July 2024 404(10448):145-155

Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? Insights from post-hoc analysis of EXSCEL

Authors: Gooding, Kim M., Stevens, Susanna, Lokhnygina, Yuliya, Giczewska, Anna, Shore, Angela C., Holman, Rury R.

Source: In Diabetes Research and Clinical Practice June 2024 212

Regional variation in cause of death in patients with type 2 diabetes: Insights from EXSCEL

Authors: Rao, Vishal N., Sharma, Abhinav, Stebbins, Amanda, Buse, John B., Katona, Brian G., Pagidipati, Neha J., Holman, Rury R., Hernandez, Adrian, Mentz, Robert J., Lopes, Renato D.

Source: In American Heart Journal May 2024 271:123-135

Sex differences in the complications, care and clinical outcomes of patients with type 2 diabetes in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)

Authors: Green, Jennifer B., Merrill, Peter, Lokhnygina, Yuliya, Mentz, Robert J., Alfredsson, Joakim, Holman, Rury R.

Source: Diabetes, obesity & metabolism. 25(6):1473-1484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181082047.0x000001&indx=1&recIds=ETOCvdc_100181082047.0x000001

Impact of baseline kidney function on the effects of sodium‐glucose co‐transporter‐2 inhibitors on kidney and heart failure outcomes: A systematic review and meta‐analysis of randomized controlled trials

Authors: Maddaloni, Ernesto, Cavallari, Ilaria, La Porta, Ylenia, Appetecchia, Alessandro, D'Onofrio, Luca, Grigioni, Francesco, Buzzetti, Raffaella, Holman, Rury R.

Source: Diabetes, obesity & metabolism. 25(5):1341-1350

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178753149.0x000001&indx=1&recIds=ETOCvdc_100178753149.0x000001

Joint longitudinal and time‐to‐event modelling compared with standard Cox modelling in patients with type 2 diabetes with and without established cardiovascular disease: An analysis of the EXSCEL trial

Authors: Oulhaj, Abderrahim, Aziz, Faisal, Suliman, Abubaker, Iqbal, Nayyar, Coleman, Ruth L., Holman, Rury R., Sourij, Harald

Source: Diabetes, obesity & metabolism. 25(5):1261-1270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178753052.0x000001&indx=1&recIds=ETOCvdc_100178753052.0x000001

An Outcome Model Approach to Translating a Randomized Controlled Trial Results to a Target Population

Authors: Goldstein, Benjamin A., Phelan, Matthew, Pagidipati, Neha J., Holman, Rury R., Stuart, Michael J. Pencina Elizabeth A

Subject Terms: Statistics - Applications, Statistics - Machine Learning

Access URL: http://arxiv.org/abs/1806.09692

Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study

Authors: Dennis, John M ^*, Young, Katherine G, McGovern, Andrew P, Mateen, Bilal A, Vollmer, Sebastian J, Simpson, Michael D, Henley, William E, Holman, Rury R, Sattar, Naveed, Pearson, Ewan R, Hattersley, Andrew T, Jones, Angus G ^*, Shields, Beverley M ^*

Source: In The Lancet Digital Health December 2022 4(12):e873-e883

Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis

Authors: Nazarzadeh, Milad, Bidel, Zeinab, Canoy, Dexter, Copland, Emma, Bennett, Derrick A, Dehghan, Abbas, Davey Smith, George, Holman, Rury R, Woodward, Mark, Gupta, Ajay, Adler, Amanda I, Wamil, Malgorzata, Sattar, Naveed, Cushman, William C, McManus, Richard J, Teo, Koon, Davis, Barry R, Chalmers, John, Pepine, Carl J, Rahimi, Kazem

Source: Lancet.Diabetes & endocrinology. 10(9):645-654

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183239268.0x000001&indx=1&recIds=ETOCvdc_100183239268.0x000001

Empagliflozin in acute myocardial infarction: the EMMY trial

Authors: von Lewinski, Dirk, Kolesnik, Ewald, Tripolt, Norbert J, Pferschy, Peter N, Benedikt, Martin, Wallner, Markus, Alber, Hannes, Berger, Rudolf, Lichtenauer, Michael, Saely, Christoph H, Moertl, Deddo, Auersperg, Pia, Reiter, Christian, Rieder, Thomas, Siller-Matula, Jolanta M, Gager, Gloria M, Hasun, Matthias, Weidinger, Franz, Pieber, Thomas R, Zechner, Peter M, Herrmann, Markus, Zirlik, Andreas, Holman, Rury R, Oulhaj, Abderrahim, Sourij, Harald

Source: European heart journal. 43(41):4421-4432

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164791954.0x000001&indx=1&recIds=ETOCvdc_100164791954.0x000001

Health utilities in Chinese patients with coronary heart disease and impaired glucose tolerance (ACE): A longitudinal analysis of a randomized, double‐blind, placebo‐controlled trial

Authors: Leal, José, Becker, Frauke, Lim, Lee‐Ling, Holman, Rury R., Gray, Alastair M.

Source: Journal of diabetes. 14(7):455-464

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156729816.0x000001&indx=1&recIds=ETOCvdc_100156729816.0x000001

Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis

Authors: Agodoa, L, Algra, A, Asselbergs, F W, Beckett, N, Berge, E, Black, H, Brouwers, F P J, Brown, M, Bulpitt, C J, Byington, B, Cutler, J, Devereaux, R B, Dwyer, J, Estacio, R, Fagard, R, Fox, K, Fukui, T, Imai, Y, Ishii, M, Julius, S, Kanno, Y, Kjeldsen, S E, Kostis, J, Kuramoto, K, Lanke, J, Lewis, E, Lewis, J, Lievre, M, Lindholm, L H, Lueders, S, MacMahon, S, Mancia, G, Matsuzaki, M, Mehlum, M H, Nissen, S, Ogawa, H, Ogihara, T, Ohkubo, T, Palmer, C, Patel, A, Pfeffer, M, Poulter, N R, Rakugi, H, Reboldi, G, Reid, C, Remuzzi, G, Ruggenenti, P, Saruta, T, Schrader, J, Schrier, R, Sever, P, Sleight, P, Staessen, J A, Suzuki, H, Thijs, L, Ueshima, K, Umemoto, S, van Gilst, W H, Verdecchia, P, Wachtell, K, Whelton, P, Wing, L, Yui, Y, Yusuf, S, Zanchetti, A, Zhang, Z Y, Anderson, C, Baigent, C, Brenner, BM, Collins, R, de Zeeuw, D, Lubsen, J, Malacco, E, Neal, B, Perkovic, V, Pitt, B, Rodgers, A, Rothwell, P, Salimi-Khorshidi, G, Sundström, J, Turnbull, F, Viberti, G, Wang, J, Nazarzadeh, Milad, Bidel, Zeinab, Canoy, Dexter, Copland, Emma, Bennett, Derrick A, Dehghan, Abbas, Davey Smith, George, Holman, Rury R, Woodward, Mark, Gupta, Ajay, Adler, Amanda I, Wamil, Malgorzata, Sattar, Naveed, Cushman, William C, McManus, Richard J, Teo, Koon, Davis, Barry R, Chalmers, John, Pepine, Carl J, Rahimi, Kazem ^*

Source: In The Lancet Diabetes & Endocrinology September 2022 10(9):645-654

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities.

Authors: Loesch, Douglas P., Garg, Manik, Matelska, Dorota, Vitsios, Dimitrios, Jiang, Xiao, Ritchie, Scott C., Sun, Benjamin B., Runz, Heiko, Whelan, Christopher D., Holman, Rury R., Mentz, Robert J., Moura, Filipe A., Wiviott, Stephen D., Sabatine, Marc S., Udler, Miriam S., Gause-Nilsson, Ingrid A., Petrovski, Slavé, Oscarsson, Jan, Nag, Abhishek, Paul, Dirk S.

Source: Nature Communications; 3/3/2025, Vol. 16 Issue 1, p1-16, 16p

Subject Terms: TYPE 2 diabetes, MONOGENIC & polygenic inheritance (Genetics), COMPLEMENT activation, CAUSAL inference, DRUG target

The Science of Diabetes and a Life of Trials: The 2024 Banting Medal for Scientific Achievement Award Lecture.

Authors: Holman, Rury R.¹ (AUTHOR) rury.holman@dtu.ox.ac.uk

Source: Diabetes. Feb2025, Vol. 74 Issue 2, p164-174. 11p.

Subject Terms: *MEDICAL personnel, *TYPE 2 diabetes, *SODIUM-glucose cotransporter 2 inhibitors, *HORMONE therapy, *GLUCAGON-like peptide 1, *GLUCOSE tolerance tests, *BLOOD sampling

Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL.

Authors: Maddaloni, Ernesto, Nguyen, Maggie, Shah, Svati H., Holman, Rury R.

Source: Diabetes Care; Feb2025, Vol. 48 Issue 2, p235-242, 8p

Subject Terms: PROPORTIONAL hazards models, OSTEOPROTEGERIN, TYPE 2 diabetes, LIKELIHOOD ratio tests, OSTEOCALCIN

Using QALYs as an Outcome for Assessing Global Prediction Accuracy in Diabetes Simulation Models.

Authors: Dakin, Helen A., Gao, Ni, Leal, José, Holman, Rury R., Tran-Duy, An, Clarke, Philip

Source: Medical Decision Making; Jan2025, Vol. 45 Issue 1, p45-59, 15p

Lifetime cost-effectiveness simulation of once-weekly exenatide in type 2 diabetes: A cost-utility analysis based on the EXSCEL trial

Authors: Becker, Frauke, Dakin, Helen A., Reed, Shelby D., Li, Yanhong, Leal, José, Gustavson, Stephanie M., Wittbrodt, Eric, Hernandez, Adrian F., Gray, Alastair M., Holman, Rury R.

Source: In Diabetes Research and Clinical Practice January 2022 183

Polyvascular disease and increased risk of cardiovascular events in patients with type 2 diabetes: Insights from the EXSCEL trial

Authors: Samsky, Marc D., Mentz, Robert J., Stebbins, Amanda, Lokhnygina, Yuliya, Aday, Aaron W., Pagidipati, Neha J., Jones, W. Schuyler, Katona, Brian G., Patel, Manesh R., Holman, Rury R., Hernandez, Adrian F., Gutierrez, Jorge Antonio

Source: In Atherosclerosis December 2021 338:1-6