Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms

Authors: St-Pierre, David, Cabana, Jérôme, Holleran, Brian J., Besserer-Offroy, Élie, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre, Leduc, Richard

Source: St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17

Subject Terms: Quantitative Biology - Molecular Networks, Quantitative Biology - Biomolecules

Access URL: http://arxiv.org/abs/1903.10968

Interplay between intracellular loop 1 and helix VIII of the angiotensin II type 2 receptor controls its activation

Authors: Connolly, Alexandre, Holleran, Brian J., Simard, Élie, Baillargeon, Jean-Patrice, Lavigne, Pierre, Leduc, Richard

Source: In Biochemical Pharmacology October 2019 168:330-338

The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice.

Authors: Pedard, Martin, Prevost, Lucie, Carpena, Camille, Holleran, Brian, Desrues, Laurence, Dubois, Martine, Nicola, Celeste, Gruel, Roxane, Godefroy, David, Deffieux, Thomas, Tanter, Mickael, Ali, Carine, Leduc, Richard, Prézeau, Laurent, Gandolfo, Pierrick, Morin, Fabrice, Wurtz, Olivier, Bonnard, Thomas, Vivien, Denis, Castel, Hélène

Source: Nature Communications; 9/29/2024, Vol. 15 Issue 1, p1-27, 27p

Subject Terms: CEREBRAL vasospasm, SUBARACHNOID hemorrhage, CEREBRAL ischemia, COGNITION disorders, TREATMENT effectiveness

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Authors: De Neve, Jolien, Breault, Émile, Previti, Santo, Vangeloven, Esaü, Loranger, Bobbi, Chartier, Magali, Brouillette, Rebecca, Lanoie, Annik, Holleran, Brian J., Longpré, Jean-Michel, Gendron, Louis, Tourwé, Dirk, Sarret, Philippe, Ballet, Steven

Source: ACS Pharmacology & Translational Science; 9/13/2024, Vol. 7 Issue 9, p2784-2798, 15p

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Authors: Jallouli, Raida, Moreno-Salinas, Ana L., Laniel, Andréanne, Holleran, Brian, Avet, Charlotte, Jacob, Joan, Hoang, Trang, Lavoie, Christine, Carmon, Kendra S., Bouvier, Michel, Leduc, Richard

Source: Cellular & Molecular Life Sciences; 9/4/2024, Vol. 81 Issue 1, p1-18, 18p

Subject Terms: G proteins, LIGANDS (Biochemistry), TRAFFIC signs & signals, CANCER cells, BREAST cancer, G protein coupled receptors

Gα s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting

Authors: Li, Xuezhi, Létourneau, Danny, Holleran, Brian, Leduc, Richard, Lavigne, Pierre, Lavoie, Christine

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Dec . 114(51), 13477-13482.

Access URL: https://www.jstor.org/stable/26485149

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms

Authors: St-Pierre, David, Cabana, Jérôme, Holleran, Brian J., Besserer-Offroy, Élie, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre, Leduc, Richard

Source: Biochemical pharmacology. 154:104-117

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094570352.0x000001&indx=1&recIds=ETOCvdc_100094570352.0x000001

GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation

Authors: Tutunea-Fatan, Elena, Abd-Elrahman, Khaled, Thibodeau, Jean-Francois, Holterman, Chet, Holleran, Brian, Leduc, Richard, Kennedy, Christopher, Gros, Robert, Ferguson, Stephen

Source: Scientific reports. 8(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174211514.0x000001&indx=1&recIds=ETOCvdc_100174211514.0x000001

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations

Authors: Cabana, Jérôme ^{‡, §}, Holleran, Brian ^‡, Leduc, Richard ^‡, Escher, Emanuel ^‡, Guillemette, Gaétan ^‡, Lavigne, Pierre ^{§, ¶, 1}

Source: In Journal of Biological Chemistry 19 June 2015 290(25):15835-15854

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity

Authors: Domazet, Ivana, Holleran, Brian J., Richard, Alexandra, Vandenberghe, Camille, Lavigne, Pierre, Escher, Emanuel, Leduc, Richard, Guillemette, Gaétan ^*

Source: In Molecular Pharmacology June 2015 87(6):982-995

Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor

Authors: Sainsily, Xavier, Cabana, Jérôme, Holleran, Brian J., Escher, Emanuel, Lavigne, Pierre, Leduc, Richard

Source: In Biochemical Pharmacology 15 November 2014 92(2):280-288

Identification of transmembrane domain 3, 4 & 5 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor

Authors: Sainsily, Xavier, Cabana, Jérôme, Boulais, Philip E., Holleran, Brian J., Escher, Emanuel, Lavigne, Pierre, Leduc, Richard

Source: In Biochemical Pharmacology 1 December 2013 86(11):1584-1593

Critical Hydrogen Bond Formation for Activation of the Angiotensin II Type 1 Receptor

Authors: Cabana, Jérôme, Holleran, Brian, Beaulieu, Marie-Ève, Leduc, Richard, Escher, Emanuel, Guillemette, Gaétan, Lavigne, Pierre

Source: In Journal of Biological Chemistry 25 January 2013 288(4):2593-2604

Unraveling allostery within the angiotensin II type 1 receptor for Gαq and β-arrestin coupling.

Authors: Cao, Yubo, van der Velden, Wijnand J. C., Namkung, Yoon, Nivedha, Anita K., Cho, Aaron, Sedki, Dana, Holleran, Brian, Lee, Nicholas, Leduc, Richard, Muk, Sanychen, Le, Keith, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Laporte, Stéphane A.

Source: Science Signaling; 8/8/2023, Vol. 16 Issue 797, p1-15, 15p

Subject Terms: G protein coupled receptors, ARRESTINS, ANGIOTENSIN II, TRANSMEMBRANE domains, SCAFFOLD proteins, MOLECULAR dynamics, G proteins

Analysis of Transmembrane Domains 1 and 4 of the Human Angiotensin II AT1 Receptor by Cysteine-scanning Mutagenesis

Authors: Yan, Liping, Holleran, Brian J., Lavigne, Pierre, Escher, Emanuel, Guillemette, Gaétan, Leduc, Richard

Source: In Journal of Biological Chemistry 22 January 2010 285(4):2284-2293

The Fifth Transmembrane Domain of Angiotensin II Type 1 Receptor Participates in the Formation of the Ligand-binding Pocket and Undergoes a Counterclockwise Rotation upon Receptor Activation

Authors: Domazet, Ivana, Martin, Stéphane S., Holleran, Brian J., Morin, Marie-Ève, Lacasse, Patrick, Lavigne, Pierre, Escher, Emanuel, Leduc, Richard, Guillemette, Gaétan

Source: In Journal of Biological Chemistry 13 November 2009 284(46):31953-31961

Activation Induces Structural Changes in the Liganded Angiotensin II Type 1 Receptor

Authors: Clément, Martin, Cabana, Jérôme, Holleran, Brian J., Leduc, Richard, Guillemette, Gaétan, Lavigne, Pierre, Escher, Emanuel

Source: In Journal of Biological Chemistry 25 September 2009 284(39):26603-26612

The Second Transmembrane Domain of the Human Type 1 Angiotensin II Receptor Participates in the Formation of the Ligand Binding Pocket and Undergoes Integral Pivoting Movement during the Process of Receptor Activation

Authors: Domazet, Ivana, Holleran, Brian J., Martin, Stéphane S., Lavigne, Pierre, Leduc, Richard, Escher, Emanuel, Guillemette, Gaétan

Source: In Journal of Biological Chemistry 1 May 2009 284(18):11922-11929

Identification of transmembrane domain 6 & 7 residues that contribute to the binding pocket of the urotensin II receptor

Authors: Holleran, Brian J., Domazet, Ivana, Beaulieu, Marie-Eve, Yan, Li Ping, Guillemette, Gaétan, Lavigne, Pierre, Escher, Emanuel, Leduc, Richard

Source: In Biochemical Pharmacology 2009 77(8):1374-1382

Mutational Analysis of the Conserved Asp2.50 and ERY Motif Reveals Signaling Bias of the Urotensin II Receptor

Authors: Proulx, Christophe D., Holleran, Brian J., Boucard, Antony A., Escher, Emanuel, Guillemette, Gaétan, Leduc, Richard ^*

Source: In Molecular Pharmacology September 2008 74(3):552-561