Upregulation of mitochondrial function is associated with advanced prostate cancer

Authors: Valentin Baumgartner, Thomas Paul Scherer, Ashkan Mortezavi, Niels Rupp, Holger Moch, Peter Wild, Susanne Dettwiler, Miriam Wanner, Dominik Enderlin, Souzan Salemi, Daniel Eberli

Source: Advances in Cancer Biology - Metastasis, Vol 13, Iss , Pp 100131- (2025)

Subject Terms: Prostate cancer, Mitochondria, Tissue microarray, Gleason, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667394024000182; https://doaj.org/toc/2667-3940

Access URL: https://doaj.org/article/4b2af385258a4795a89cf42dc68c19aa

Molecular and functional landscape of malignant serous effusions for precision oncology

Authors: Rebekka Wegmann, Lorenz Bankel, Yasmin Festl, Kate Lau, Sohyon Lee, Fabian Arnold, Valentina Cappelletti, Aaron Fehr, Paola Picotti, Konstantin J. Dedes, Daniel Franzen, Daniela Lenggenhager, Peter K. Bode, Martin Zoche, Holger Moch, Christian Britschgi, Berend Snijder

Source: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6040e8b387b24847845fb184ce64f893

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

Authors: Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194

Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors

Authors: Mart van Rijthoven, Simon Obahor, Fabio Pagliarulo, Maries van den Broek, Peter Schraml, Holger Moch, Jeroen van der Laak, Francesco Ciompi, Karina Silina

Source: Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/0ae3f5aeefc243b794418080e7ea09ca

Outcomes of robot-assisted laparoscopic extended pelvic lymph node dissection for prostate Cancer

Authors: Silvan Sigg, Fabienne Lehner, Etienne Xavier Keller, Karim Saba, Holger Moch, Tullio Sulser, Daniel Eberli, Ashkan Mortezavi

Source: BMC Urology, Vol 24, Iss 1, Pp 1-10 (2024)

Subject Terms: Outcome, Lymph node dissection, Prostate cancer, Laparoscopic, Robotic, da Vinci, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2490

Access URL: https://doaj.org/article/739e11d3bfba408ea2ea7695a1baf8cc

ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features

Authors: Miriam Forster‐Sack, Martin Zoche, Bernhard Pestalozzi, Isabell Witzel, Esther Irene Schwarz, Joel Julien Herzig, Hisham Fansa, Christoph Tausch, Jeff Ross, Holger Moch, Zsuzsanna Varga

Source: The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)

Subject Terms: lobular carcinoma, ERBB2/CDK12 coamplification, lobular ERBB2 mutations, poor prognosis, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/13291e3d61084c708b8a14a0bfc7d206

Altered cytoplasmic and nuclear ADP‐ribosylation levels analyzed with an improved ADP‐ribose binder are a prognostic factor in renal cell carcinoma

Authors: Peter Schraml, Fabio Aimi, Martin Zoche, Domingo Aguilera‐Garcia, Fabian Arnold, Holger Moch, Michael O Hottiger

Source: The Journal of Pathology: Clinical Research, Vol 9, Iss 4, Pp 273-284 (2023)

Subject Terms: ADP‐ribosylation, PARP, inhibitors, kidney, cancer, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/55e05afe0c5e466fb804e85911cafbf8

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

Authors: Lara Planas‐Paz, Alicia Pliego‐Mendieta, Catherine Hagedorn, Domingo Aguilera‐Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A Rubin, Holger Moch, Christian Britschgi, Chantal Pauli

Source: EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-21 (2023)

Subject Terms: genomic instability, HRDness, HRD score, sarcoma, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/d874520ba4d8464eacd895ed33371d67

Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment

Authors: Raphael O. Betschart, Alexandre Thiéry, Domingo Aguilera-Garcia, Martin Zoche, Holger Moch, Raphael Twerenbold, Tanja Zeller, Stefan Blankenberg, Andreas Ziegler

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e28a449f484640c3b5dbb2ca21b8eaaa

A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy

Authors: Florian A. Büttner, Stefan Winter, Viktoria Stühler, Steffen Rausch, Jörg Hennenlotter, Susanne Füssel, Stefan Zastrow, Matthias Meinhardt, Marieta Toma, Carmen Jerónimo, Rui Henrique, Vera Miranda-Gonçalves, Nils Kröger, Silvia Ribback, Arndt Hartmann, Abbas Agaimy, Christine Stöhr, Iris Polifka, Falko Fend, Marcus Scharpf, Eva Comperat, Gabriel Wasinger, Holger Moch, Arnulf Stenzl, Marco Gerlinger, Jens Bedke, Matthias Schwab, Elke Schaeffeler

Source: Genome Medicine, Vol 14, Iss 1, Pp 1-19 (2022)

Subject Terms: Renal cell carcinoma, Cancer-specific survival, RCC subtypes, Gene expression deconvolution, Immunotherapy, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/876bc134c9284335b9606279982c1274

Alterations in homologous recombination repair genes in prostate cancer brain metastases

Authors: Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin

Source: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/42966ddd44de4ed4a87861f3d4c3176c

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

Authors: Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia, Andrea Rinaldi, Ricardo Pereira Mestre, Eugenia D’Antonio, Matteo Ferrari, Flavio Stoffel, Fernando Jermini, Silke Gillessen, Lukas Bubendorf, Peter Schraml, Arianna Calcinotto, Eva Corey, Holger Moch, Martin Spahn, George Thalmann, Marianna Kruithof-de Julio, Mark A. Rubin, Jean-Philippe P. Theurillat

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3

Impact of differing methodologies for serum miRNA-371a-3p assessment in stage I testicular germ cell cancer recurrence

Authors: Ailsa J. Christiansen, João Lobo, Christian D. Fankhauser, Christian Rothermundt, Richard Cathomas, Aashil A. Batavia, Josias B. Grogg, Arnoud J. Templeton, Anita Hirschi-Blickenstorfer, Anja Lorch, Silke Gillessen, Holger Moch, Jörg Beyer, Thomas Hermanns

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: miRNA - microRNA, germ cell testicular cancer, serum biomarker, method optimization, clinical implementation, disease recurrence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1056823/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/9039fb352c16400a82b9ed88cda7aed2

Modified immunoscore improves the prediction of progression-free survival in patients with non-muscle-invasive bladder cancer: A digital pathology study

Authors: Uwe Bieri, Dominik Enderlin, Lorenz Buser, Marian S. Wettstein, Daniel Eberli, Holger Moch, Thomas Hermanns, Cédric Poyet

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: bladder cancer, immunoscore, biomarker, progression, prognosis, digital pathology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.964672/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/d75729fb2ea14688b5b5a16afed77a2f

Higher prevalence of pulmonary macrothrombi in SARS‐CoV‐2 than in influenza A: autopsy results from ‘Spanish flu’ 1918/1919 in Switzerland to Coronavirus disease 2019

Authors: Nina Maria Burkhard‐Koren, Martina Haberecker, Umberto Maccio, Frank Ruschitzka, Reto A Schuepbach, Annelies S Zinkernagel, Thomas Hardmeier, Zsuzsanna Varga, Holger Moch

Source: The Journal of Pathology: Clinical Research, Vol 7, Iss 2, Pp 135-143 (2021)

Subject Terms: influenza A, COVID‐19, pulmonary embolism, autopsy, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/0d0b644479234f828f39f1e8c13c921b

Use of Diagnostic Algorithms for NTRK Fusion-Positive Tumors in Pathology Institutes in Switzerland

Authors: Holger Moch, Gieri Cathomas, Milo Frattini, Wolfram Jochum, Erik Vassella, Laurence de Leval, Joachim Diebold, Christian Britschgi, Thomas McKee, Lukas Bubendorf

Source: healthbook TIMES. Oncology Hematology, Vol 1, Iss 7, Pp 14-21 (2021)

Subject Terms: tumor-agnostic agent, trk inhibitor, ntrk gene fusion, next generation sequencing (ngs), immunohistochemistry (ihc), fluorescence in situ hybridization (fish), Medicine

File Description: electronic resource

Relation: https://onco-hema.healthbooktimes.org/article/25715-use-of-diagnostic-algorithms-for-ntrk-fusion-positive-tumors-in-pathology-institutes-in-switzerland; https://doaj.org/toc/2673-2092; https://doaj.org/toc/2673-2106

Access URL: https://doaj.org/article/cd0f6a5afccc4310b9147d52ed3cf998

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer

Authors: Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f2c4c2cbe140413794b564af2e6c8775

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

Authors: Paulino Tallón de Lara, Héctor Castañón, Marijne Vermeer, Nicolás Núñez, Karina Silina, Bettina Sobottka, Joaquín Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sònia Tugues, Burkhard Becher, Maries van den Broek

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d4c93583ff8e4ff4b53a6a528ca96962

Differential PD-1/LAG-3 expression and immune phenotypes in metastatic sites of breast cancer

Authors: Bettina Sobottka, Holger Moch, Zsuzsanna Varga

Source: Breast Cancer Research, Vol 23, Iss 1, Pp 1-11 (2021)

Subject Terms: Breast cancer, Metastasis, Tumor immunology, Immune checkpoint receptors, Immune phenotype, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/81b8df352ae5493f8b726202e50f4b9b

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Authors: Ronny Nienhold, Yari Ciani, Viktor H. Koelzer, Alexandar Tzankov, Jasmin D. Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten D. Mertz

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7f0708cc25564852941e5c8e8dff32c6