Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes

Authors: Kohoutova, Zuzana ^a, Prchalova, Eliska ^a, Andrys, Rudolf ^a, Knittelova, Karolina ^a, Formanova, Marketa ^a, Hofmanova, Tereza ^a, Psotka, Miroslav ^{a, b}, Musilek, Kamil ^{a, b}, Derat, Etienne ^{c, ⁎}, Malinak, David ^{a, b, ⁎⁎}

Source: In Bioorganic Chemistry December 2024 153

N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer’s Disease

Authors: Hofmanova, Tereza, Marques, Carolina, García-Sosa, Alfonso T., López, Óscar, Leitzbach, Luisa, Carreiro, Elisabete P., González-Bakker, Aday, Puerta, Adrián, Stark, Holger, Padrón, José M., Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Results in Chemistry December 2023 6

Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents

Authors: Zorbaz, Tamara, Malinak, David, Hofmanova, Tereza, Maraković, Nikola, Žunec, Suzana, Hrvat, Nikolina Maček, Andrys, Rudolf, Psotka, Miroslav, Zandona, Antonio, Svobodova, Jana, Prchal, Lukas, Fingler, Sanja, Katalinić, Maja, Kovarik, Zrinka, Musilek, Kamil

Source: In European Journal of Medicinal Chemistry 5 August 2022 238

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Authors: Prchalova, Eliska, Andrys, Rudolf, Pejchal, Jaroslav, Kohoutova, Zuzana, Knittelova, Karolina, Hofmanova, Tereza, Skarka, Adam, Dlabkova, Alzbeta, Psotka, Miroslav, Prchal, Lukas, Musilek, Kamil, Karasova, Jana Zdarova, Malinak, David

Source: Archives of Toxicology; Sep2024, Vol. 98 Issue 9, p2937-2952, 16p

Subject Terms: NERVE gases, BUTYRYLCHOLINESTERASE, OXIMES, CHOLINESTERASES, NUCLEOPHILIC reactions

FLUORINATED AND CHLORINATED PYRIDINIUM OXIMES REACTIVATING CHOLINESTERASES INHIBITED BY NERVE AGENTS.

Authors: Malinak, David, Zorbaz, Tamara, Hofmanova, Tereza, Andrys, Rudolf, Psotka, Miroslav, Svobodova, Jana, Prchal, Lukas, Kovarik, Zrinka, Musilek, Kamil

Source: Military Medical Science Letters / Vojenské zdravotnické Listy; 2022 Supplement, Vol. 91, p54-54, 1p

Subject Terms: OXIMES, CHOLINESTERASES, SYNAPSES

SYNTHESIS AND IN VITRO EVALUATION OF NONSYMMETRICAL MONOQUATERNARY AMMONIUM SALTS AS POTENTIAL REACTIVATORS OF INHIBITED CHOLINESTERASES.

Authors: Kohoutova, Zuzana, Malinak, David, Hofmanova, Tereza, Andrys, Rudolf, Prchal, Lukas, Svobodova, Jana, Musilek, Kamil

Source: Military Medical Science Letters / Vojenské zdravotnické Listy; 2022 Supplement, Vol. 91, p44-44, 1p

Subject Terms: ORGANOPHOSPHORUS compounds, CHOLINESTERASES, OXIMES