3BP-3940, a highly potent FAP-targeting peptide for theranostics - production, validation and first in human experience with Ga-68 and Lu-177

Authors: Greifenstein, Lukas ^{1, 3, ∗}, Gunkel, Annika ¹, Hoehne, Aileen ², Osterkamp, Frank ², Smerling, Christiane ², Landvogt, Christian ¹, Mueller, Corinna ¹, Baum, Richard P. ¹

Source: In iScience 15 December 2023 26(12)

Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy.

Authors: Zboralski, Dirk¹ (AUTHOR) dirk.zboralski@3b-pharma.com, Hoehne, Aileen¹ (AUTHOR), Bredenbeck, Anne¹ (AUTHOR), Schumann, Anne¹ (AUTHOR), Nguyen, Minh² (AUTHOR), Schneider, Eberhard¹ (AUTHOR), Ungewiss, Jan¹ (AUTHOR), Paschke, Matthias¹ (AUTHOR), Haase, Christian¹ (AUTHOR), von Hacht, Jan L.¹ (AUTHOR), Kwan, Tanya² (AUTHOR), Lin, Kevin K.² (AUTHOR), Lenore, Jan² (AUTHOR), Harding, Thomas C.² (AUTHOR), Xiao, Jim² (AUTHOR), Simmons, Andrew D.² (AUTHOR), Mohan, Ajay-Mohan³ (AUTHOR), Beindorff, Nicola³ (AUTHOR), Reineke, Ulrich¹ (AUTHOR), Smerling, Christiane¹ (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Sep2022, Vol. 49 Issue 11, p3651-3667. 17p. 1 Color Photograph, 1 Diagram, 7 Graphs.

Subject Terms: *FIBROBLASTS, *RECOMBINANT proteins, *PEPTIDES, *AUTORADIOGRAPHY, *TUMOR microenvironment, *AFFINITY chromatography, *RADIONUCLIDE imaging

Preclinical Characterization of DPI-4452: A ⁶⁸Ga/¹⁷⁷Lu Theranostic Ligand for Carbonic Anhydrase IX.

Authors: Massière, Frédéric, Wiedemann, Norbert, Borrego, Inês, Hoehne, Aileen, Osterkamp, Frank, Paschke, Matthias, Zboralski, Dirk, Schumann, Anne, Bredenbeck, Anne, Brichory, Franck, Attinger, Antoine

Source: Journal of Nuclear Medicine; May2024, Vol. 65 Issue 5, p761-767, 7p

[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Authors: Hoehne, Aileen, James, Michelle, Alam, Israt, Ronald, John, Schneider, Bernadette, D'Souza, Aloma, Witney, Timothy, Andrews, Lauren, Cropper, Haley, Behera, Deepak, Gowrishankar, Gayatri, Ding, Zhaoqing, Wyss-Coray, Tony, Chin, Frederick, Biswal, Sandip, Gambhir, Sanjiv

Source: Journal of neuroinflammation. 15(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161441980.0x000001&indx=1&recIds=ETOCvdc_100161441980.0x000001

Imaging B Cells in a Mouse Model of Multiple Sclerosis Using ^6^4Cu-Rituximab PET

Authors: James, Michelle L., Hoehne, Aileen, Mayer, Aaron T., Lechtenberg, Kendra, Moreno, Monica, Gowrishankar, Gayatri, Ilovich, Ohad, Natarajan, Arutselvan, Johnson, Emily M., Nguyen, Joujou

Source: Journal of nuclear medicine. 58(11):1845-1851

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613649201&indx=1&recIds=ETOCRN613649201

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

Authors: Chan, Carmel T., Reeves, Robert E., Geller, Ron, Yaghoubi, Shahriar S., Hoehne, Aileen, Solow-Cordero, David E., Chiosis, Gabriela, Massoud, Tarik F., Paulmurugan, Ramasamy, Gambhir, Sanjiv S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Sep 01. 109(37), 14740-14741.

Access URL: https://www.jstor.org/stable/41706289

Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition.

Authors: Zboralski, Dirk, Osterkamp, Frank, Christensen, Esben, Bredenbeck, Anne, Schumann, Anne, Hoehne, Aileen, Schneider, Eberhard, Paschke, Matthias, Ungewiss, Jan, Haase, Christian, Robillard, Liliane, Simmons, Andrew D., Harding, Thomas C., Nguyen, Minh

Source: European Journal of Nuclear Medicine & Molecular Imaging; Jul2023, Vol. 50 Issue 9, p2621-2635, 15p, 2 Color Photographs, 5 Graphs

Subject Terms: IMMUNE checkpoint inhibitors, TUMOR microenvironment, PROGRAMMED cell death 1 receptors, GENE expression, FIBROBLASTS, TYPE I interferons

Modelling ligand depletion for simultaneous affinity and binding site quantification on cells and tissue.

Authors: Weber, Judith, Djurberg, Klara, Lundsten Salomonsson, Sara, Kamprath, Maria, Hoehne, Aileen, Westin, Hadis, Vergara, Fernanda, Bondza, Sina

Source: Scientific Reports; 6/20/2023, Vol. 13 Issue 1, p1-14, 14p

Subject Terms: BINDING sites, BIOLOGICAL systems, PEPTIDES, DRUG development, ESSENTIAL drugs

[¹⁸F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis.

Authors: Hoehne, Aileen¹, James, Michelle L.^1,2, Alam, Israt S.¹, Ronald, John A.¹, Schneider, Bernadette¹, D’Souza, Aloma¹, Witney, Timothy H.¹, Andrews, Lauren E.¹, Cropper, Haley C.¹, Behera, Deepak¹, Gowrishankar, Gayatri¹, Zhaoqing Ding², Wyss-Coray, Tony², Chin, Frederick T.¹, Biswal, Sandip¹, Gambhir, Sanjiv S.^1,3 sgambhir@stanford.edu, D'Souza, Aloma⁴, Ding, Zhaoqing⁵

Source: Journal of Neuroinflammation. 2/22/2018, p10-21. 12p.

Subject Terms: *MULTIPLE sclerosis, *CYSTINE, *GLUTAMIC acid, *IMMUNE response, *ENCEPHALOMYELITIS

Feasibility, Biodistribution and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy (PTRT) of Diverse Adenocarcinomas using ¹⁷⁷Lu-FAP-2286: Firstin- Human Results.

Authors: Baum, Richard P., Schuchardt, Christiane, Singh, Aviral, Chantadisai, Maythinee, Robiller, Franz C., Jingjing Zhang, Mueller, Dirk, Eismant, Alexander, Almaguel, Frankis, Zboralski, Dirk, Osterkamp, Frank, Hoehne, Aileen, Reineke, Ulrich, Smerling, Christiane, Kulkarni, Harshad R.

Source: Journal of Nuclear Medicine; Dec2021, Vol. 62 Issue 12, Following p1-32, 45p

Feasibility, Biodistribution and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy (PTRT) of Diverse Adenocarcinomas using 177Lu-FAP-2286: Firstin-Human Results.

Authors: Baum, Richard P., Schuchardt, Christiane, Singh, Aviral, Chantadisai, Maythinee, Robiller, Franz C., Jingjing Zhang, Mueller, Dirk, Eismant, Alexander, Almaguel, Frankis, Zboralski, Dirk, Osterkamp, Frank, Hoehne, Aileen, Reineke, Ulrich, Smerling, Christiane, Kulkarni, Harshad R.

Source: Journal of Nuclear Medicine; Nov2021, Vol. 62 Issue 11, p1-45, 45p

Feasibility, Biodistribution and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy (PTRT) of Diverse Adenocarcinomas using ¹⁷⁷Lu-FAP-2286: First-in-Human Results.

Authors: Baum, Richard P., Schuchardt, Christiane, Singh, Aviral, Maythinee Chantadisai, Robiller, Franz C., Jingjing Zhang, Mueller, Dirk, Eismant, Alexander, Almaguel, Frankis, Zboralski, Dirk, Osterkamp, Frank, Hoehne, Aileen, Reineke, Ulrich, Smerling, Christiane, Kulkarni, Harshad R.

Source: Journal of Nuclear Medicine; 8/1/2021, Vol. 62 Issue 8, p1-45, 45p

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Imaging B Cells in a Mouse Model of Multiple Sclerosis Using ⁶⁴Cu-Rituximab PET.

Authors: James, Michelle L., Hoehne, Aileen, Mayer, Aaron T., Lechtenberg, Kendra, Moreno, Monica, Gowrishankar, Gayatri, Ilovich, Ohad, Natarajan, Arutselvan, Johnson, Emily M., Joujou Nguyen, Quach, Lisa, Han, May, Buckwalter, Marion, Chandra, Sudeep, Gambhir, Sanjiv S.

Source: Journal of Nuclear Medicine; Nov2017, Vol. 58 Issue 11, p1845-1851, 7p, 4 Graphs