Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

Authors: Hodder, Anthony N., Christensen, Janni, Scally, Stephen, Triglia, Tony, Ngo, Anna, Birkinshaw, Richard W., Bailey, Brodie, Favuzza, Paola, Dietrich, Melanie H., Tham, Wai-Hong, Czabotar, Peter E., Lowes, Kym, Guo, Zhuyan, Murgolo, Nicholas, Lera Ruiz, Manuel de, McCauley, John A., Sleebs, Brad E., Olsen, David, Cowman, Alan F.

Source: In Structure 7 July 2022 30(7):947-961

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors.

Authors: Hodder, Anthony N.^1,2 (AUTHOR), Sleebs, Brad E.^1,2 (AUTHOR), Adams, Greg³ (AUTHOR), Rezazadeh, Sina³ (AUTHOR), Ngo, Anna^1,2 (AUTHOR), Jarman, Kate^1,2 (AUTHOR), Scally, Stephen^1,2 (AUTHOR), Czabotar, Peter^1,2 (AUTHOR), Wang, Hongwu³ (AUTHOR), McCauley, John A.³ (AUTHOR), Olsen, David B.³ (AUTHOR), Cowman, Alan F.^1,2 (AUTHOR) cowman@wehi.edu.au

Source: FEBS Journal. Mar2025, p1. 22p. 9 Illustrations, 3 Charts.

Structure of the Plasmodium falciparum PfSERA5 pseudo‐zymogen

Authors: Smith, Nicholas A., Clarke, Oliver B., Lee, Mihwa, Hodder, Anthony N., Smith, Brian J.

Source: Protein science. 29(11):2245-2258

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108689063.0x000001&indx=1&recIds=ETOCvdc_100108689063.0x000001

Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development.

Authors: McConville, Robyn, Krol, Jelte M. M., Steel, Ryan W. J., O'Neill, Matthew T., Davey, Bethany K., Hodder, Anthony N., Nebl, Thomas, Cowman, Alan F., Kneteman, Norman, Boddey, Justin A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/9/2024, Vol. 121 Issue 28, p1-17, 29p

Subject Terms: PLASMODIUM falciparum, SPOROZOITES, CIRCUMSPOROZOITE protein, LIVER proteins, PLASMODIUM berghei

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics

Authors: Nguyen, William, Hodder, Anthony N., de Lezongard, Richard Bestel, Czabotar, Peter E., Jarman, Kate E., O'Neill, Matthew T., Thompson, Jennifer K., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Source: In European Journal of Medicinal Chemistry 25 June 2018 154:182-198

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

Authors: Wong, Wilson, Huang, Rick, Menant, Sebastien, Hong, Chuan, Sandow, Jarrod J., Birkinshaw, Richard W., Healer, Julie, Hodder, Anthony N., Kanjee, Usheer, Tonkin, Christopher J., Heckmann, Denise, Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, Duraisingh, Manoj T., Czabotar, Peter E., de Jongh, Willem A., Tham, Wai-Hong, Webb, Andrew I., Yu, Zhiheng, Cowman, Alan F.

Source: Nature. 565(7737):118-121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193366686.0x000001&indx=1&recIds=ETOCvdc_100193366686.0x000001

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

Authors: Richardson, Lachlan W., Ashton, Trent D., Dans, Madeline G., Nguyen, Nghi, Favuzza, Paola, Triglia, Tony, Hodder, Anthony N., Ngo, Anna, Jarman, Kate E., Cowman, Alan F., Sleebs, Brad E.

Source: ChemMedChem. 17(18)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164933294.0x000001&indx=1&recIds=ETOCvdc_100164933294.0x000001

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Authors: Gazdik, Michelle, Jarman, Kate E., O’Neill, Matthew T., Hodder, Anthony N., Lowes, Kym N., Jousset Sabroux, Helene, Cowman, Alan F., Boddey, Justin A., Sleebs, Brad E.

Source: In Bioorganic & Medicinal Chemistry 1 May 2016 24(9):1993-2010

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria

Authors: Chiu, Chris Y. H., Hodder, Anthony N., Lin, Clara S., Hill, Danika L., Suen, Connie S. N. Li Wai, Schofield, Louis, Siba, Peter M., Mueller, Ivo, Cowman, Alan F., Hansen, Diana S.

Source: The Journal of Infectious Diseases, 2015 Aug 01. 212(3), 406-415.

Access URL: http://www.jstor.org/stable/43709606

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum

Authors: Lin, Clara S., Uboldi, Alessandro D., Marapana, Danushka, Czabotar, Peter E., Epp, Christian, Bujard, Hermann, Taylor, Nicole L. ^**, Perugini, Matthew A. ^**, Hodder, Anthony N., Cowman, Alan F.

Source: In Journal of Biological Chemistry 12 September 2014 289(37):25655-25669

Synthetic peptides derived from the C-terminal 6 kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development

Authors: Kanodia, Shivani, Kumar, Gautam, Rizzi, Luca, Pedretti, Alessandro, Hodder, Anthony N., Romeo, Sergio, Malhotra, Pawan

Source: In BBA - General Subjects September 2014 1840(9):2765-2775

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Authors: Hodder, Anthony N., Czabotar, Peter E., Uboldi, Alessandro D., Clarke, Oliver B., Lin, Clara S., Healer, Julie, Smith, Brian J., Cowman, Alan F.

Source: In Journal of Biological Chemistry 21 September 2012 287(39):32922-32939

Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils

Authors: Adda, Christopher G., Murphy, Vince J., Sunde, Margaret, Waddington, Lynne J., Schloegel, Jesse, Talbo, Gert H., Vingas, Kleo, Kienzle, Vivian, Masciantonio, Rosella, Howlett, Geoffrey J., Hodder, Anthony N., Foley, Michael, Anders, Robin F.

Source: In Molecular & Biochemical Parasitology August 2009 166(2):159-171

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

Authors: Hodder, Anthony N. ^†, Malby, Robyn L. ^†, Clarke, Oliver B. ^†, Fairlie, W. Douglas, Colman, Peter M., Crabb, Brendan S., Smith, Brian J.

Source: In Journal of Molecular Biology 2009 392(1):154-165

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts

Authors: Sanders, Paul R., Cantin, Greg T., Greenbaum, Doron C., Gilson, Paul R., Nebl, Thomas, Moritz, Robert L., Yates, John R., III, Hodder, Anthony N., Crabb, Brendan S.

Source: In Molecular & Biochemical Parasitology 2007 154(2):148-157

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

Authors: Kedzierski, Lukasz ^†, Malby, Robyn L. ^†, Smith, Brian J. ^†, Perugini, Matthew A., Hodder, Anthony N., Ilg, Thomas, Colman, Peter M., Handman, Emanuela

Source: In Journal of Molecular Biology 2006 363(1):215-227

An aspartyl protease directs malaria effector proteins to the host cell.

Authors: Boddey, Justin A., Hodder, Anthony N., Günther, Svenja

Source: Nature; February 4 2010, Vol. 463, p627-631, 5p

Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum

Authors: Sanders, Paul R. ^{‡, §, ¶, 1}, Gilson, Paul R. ^‡, Cantin, Greg T. ^∥, Greenbaum, Doron C. ^{‡, 2}, Nebl, Thomas ^‡, Carucci, Daniel J. ^**, McConville, Malcolm J. ^{‡‡, 3}, Schofield, Louis ^{‡, 3}, Hodder, Anthony N. ^‡, Yates, John R., III ^∥, Crabb, Brendan S. ^{‡, 3, 4}

Source: In Journal of Biological Chemistry 2 December 2005 280(48):40169-40176

A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant

Authors: Saul, Allan ^*, Lawrence, Greg, Allworth, Anthony, Elliott, Suzanne, Anderson, Karen, Rzepczyk, Christine, Martin, Laura B., Taylor, Darrin, Eisen, Damon P., Irving, David O., Pye, David, Crewther, Pauline E., Hodder, Anthony N., Murphy, Vincent J., Anders, Robin F.

Source: In Vaccine 2005 23(23):3076-3083

Properties of GDP-mannose Pyrophosphorylase, a Critical Enzyme and Drug Target in Leishmania mexicana

Authors: Davis, Antony J. ^{‡, §}, Perugini, Matthew A. ^{§, ¶}, Smith, Brian J. ^‡, Stewart, James D. ^‡, Ilg, Thomas ^∥, Hodder, Anthony N. ^‡, Handman, Emanuela ^{‡, **}

Source: In Journal of Biological Chemistry 26 March 2004 279(13):12462-12468